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An Overview on Hyaluronic Acid

Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. Hyaluronic acid distributes widely in human body, such as in connective, epithelial, and neural tissues. It can be obtained by extracting from cockscomb or through microorganism fermentation. The product in our company is all fermented products.

Food Grade: White or almost white powder or granules
Cosmetic Grade: White or almost white powder or granules
Injection Grade: White or almost white powder or fibrous aggregates
Medical Grade: White or almost white powder or fibrous aggregates
Cross-linked HA Gel:
mono-phase cross-linked HA (Juvederm™ Type)
Material: mono-phase cross-linked HA gel with lidocaine (concentration:20 mg/ml). 1 ml syringe package.
bi-phase cross-linked HA (Restylane™ Type)
Material: bi-phase cross-linked gel (concentration: 20 mg/ml). 1 ml syringe package.
Molecular weight &viscosity
HA from different sources have the same primary structure but different molecular weight. The order of HA molecular weight ranges from 104 to 107 Dalton. HA has an incredible water-retaining capacity that makes HA solutions highly viscous, so the solution can retain moisture in the eyes, joints, and skin tissues. The clinical applications are strongly dependent on HA’s chain length, that is, the molecular weight. Intrinsic viscosity has been measured as a parameter of the molecular weight of HA, and the relation between intrinsic viscosity and molecular weight is defined by the Mark-Houwink equation.
[η]=KMα
This equation describes the dependence of the intrinsic viscosity of a polymer on its relative molecular weight. Where [η] is the intrinsic viscosity, K and α are constant the values of which depend on the nature of the polymer and solvent as well as on temperature and M is usually one of the relative molecular mass averages.
May 9, 2018 Hyaluronic Acid
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