The Powerful Lubricating Effects of High-Molecular-Weight Hyaluronic Acid

While HA is generally best known for its moisturizing action, its lubricating action is also important. In biomedical applications, such as joint lubrication, ophthalmic surgery and post-surgical anti-adhesion, HMW-HA’s lubricating effect is primarily utilized.

Fig 1. High-molecular-weight hyaluronic acid possesses lubricating and viscoelastic properties.

–Joint Lubrication: HMW-HA is the Standard

HA is a necessary component of synovial fluid, and it is for this reason that physicians manage arthritis by the administration of HA injections. Synovial fluid naturally has HA with a molecular weight between 3,000–6,000 kDa. HMW-HA (which is frequently in need of cross-linking technology) proved to be the best of all the molecular weights. Clinical observation is that in patients with osteoarthritis, the synovial HA concentrations are below 500 kDa, resulting in a >50% loss of viscoelasticity. Thus, HMW-HA injections restore synovial fluid viscosity with improved joint lubrication.

–Ophthalmic Surgery: Relies on Ultra-High Molecular Weight HA

Ophthalmic viscosurgical devices (OVDs) typically use HMW-HA (>2,000 kDa). Its high stability and viscoelasticity allow it to remain longer in the eye, providing longer protection and support and reducing intra- and post-operative complications. In contrary, lower molecular weight HA cannot provide the required rheological performance and can cause corneal edema because of osmotic pressure issues.

–Post-Surgical Anti-Adhesion: HMW-HA as the Foundation

The high viscoelasticity of HMW-HA allows it to offer a physical barrier effect in operating sites for extended periods of time, delivering long-lasting anti-adhesion results. Additionally, its lubricating nature reduces tissue friction, minimizing injury and inflammation.

High vs. Low Molecular Weight Hyaluronic Acid: Anti-Inflammatory or Pro-Inflammatory

In addition to lubrication, HMW-HA’s uses in joint injections, ophthalmic surgery, and anti-adhesion also capitalize on its anti-inflammatory properties.

Fig 2. Smaller HA molecules absorb deeper into skin

–HMW-HA Effectively Suppresses Inflammation

It forms an anti-inflammatory covering on tissue surfaces that bars inflammatory cell invasion. It also controls pro- and anti-inflammatory factors, suppressing inflammation. On top of that, HMW-HA enhances tissue stability, promoting efficient healing of wounds. Hence, it is used quite often in arthritis treatment, skincare, and eye surgery to support healing.

–LMW-HA Does Just the Reverse—It May Promote Inflammation

LMW-HA (HA in the range of 10-200 kDa) engages cell surface receptors, including TLR4, activating inflammatory signaling and amplifying the generation of pro-inflammatory cytokines. While the body naturally breaks down HA into LMW-HA during tissue injury (helping initiate immune defense), excessive amounts can lead to chronic inflammation. Therefore, its use must be carefully controlled to balance pro-inflammatory and reparative effects.

Read more: Does Hyaluronic Acid Trigger Inflammation

Can High Molecular Weight Hyaluronic Acid Achieve Anti-Aging and Life Extension

HMW-HA is present in nearly all anti-aging skincare products. It works like a super sponge, forming a barrier film on the skin’s surface that locks in moisture. This makes the skin tight and elastic, smoothing out wrinkles and fine lines. Besides hydration, the film also protects against UV damage, shielding the skin from free radicals.

Benefits of HMW-HA to the Skin:

• Improves elasticity and firmness of skin
• Avoids sagging
• Smooths texture and enhances it

Other than dermatological treatment, studies showed that high molecular weight hyaluronic acid also exhibits medical anti-aging capabilities.

A groundbreaking study published in Nature revealed that increasing expression of the nmr Has2 gene (which produces more HMW-HA) in naked mole rats extended the life of test mice.[i] The study found that HMW-HA not only inhibits cancer but can possibly increase lifespan as well.

Conclusion

Due to its triple benefit of lubrication, anti-inflammatory, and anti-aging, HMW-HA occupies a replaceable niche in the therapy of joints, surgical assistance, and aging protection. Although LMW-HA can add flexibility to certain applications, HMW-HA’s stability and protective action render it popular in many clinical and cosmetic uses.

Stanford Chemicals Company (SCC) offers high molecular weight hyaluronic acid (HA) powder suitable for the pharmaceutical, cosmetic, and research industries. For more product information, contact professionals through the Get A Quote.

[i] Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V. Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice. Nature. 2023 Sep;621(7977):196-205. doi: 10.1038/s41586-023-06463-0. Epub 2023 Aug 23. PMID: 37612507; PMCID: PMC10666664.

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In general, HA is categorized into different grades based on the application. Besides the usual cosmetic grade, medical-grade, food-grade, and injectable-grade HA also have extensive market applications. We have already touched on the variations between these types of hyaluronic acid. If you’re curious, click on the following link to learn more: Medical Grade vs. Cosmetic Grade Hyaluronic Acid: What Are the Differences.

HA was first discovered to be added to medicine over 70 years ago. It has continued to be a constantly increasing part of life sciences and medicine through continued research.

Medical Grade Hyaluronic Acid Was First Used in Ophthalmology

Hyaluronic acid is a multi-purpose matrix that occurs widely in the human body. It possesses a good lubricant and biocompatibility. Medically, it is referred to as sodium hyaluronate and is utilized in various ophthalmic surgeries, such as intraocular lens implantation, corneal transplantation, and glaucoma surgery.

Actually, the therapeutic application of HA dates back 70 years. HA was first successfully used in eye surgeries in the 1950s and remains a common practice to this day. Two decades later, HA’s moisturizing property was beautifully utilized by veterinarians when they filled horse joints with HA to improve mobility. Since then, HA has steadily expanded its role in medicine.

Read more: From Surgery to Daily Care: The Versatile Role of Sodium Hyaluronate in Eye Health

The Diverse Benefits of Medical-Grade Hyaluronic Acid

Presently, with more and more research, applications of HA in medicine are growing day by day. Besides its traditional use in ophthalmology, HA has become a major treatment modality for orthopedic conditions. In osteoarthritis and frozen shoulder, joint lubrication is greatly improved by HA injections, and cartilage is protected.

Moreover, HA use now includes gynecology, tendon fixation, and abdominal surgery, wherein it is utilized as a postoperative device. Its bioadhesive nature allows it to form a protective coating over wounds, both as a lubricant and as a mechanical coating to give the optimal environment for healing.[i] Lastly, HA supplementation is now a standard therapy for cystitis and urinary tract infection, significantly alleviating signs and symptoms with its mucosal protective effect.

HA is also pushing vaccine technology forward. By some chemical manipulations, HA holds pioneering promise as an adjuvant. When mixed with antigens, it enhances antigen-presenting efficacy, induces targeted migration to lymph nodes, and prevents inflammation at the injection site[ii]—offering new conceptual paradigms for vaccine design.

The Role of Hyaluronic Acid Depends on Its Molecular Weight

Low-molecular-weight HA (LMW-HA) can penetrate tissues better, possesses fine bioactivity, and is, therefore, good for anti-inflammatory and tissue repair. Medium-molecular-weight HA (MMW-HA) offers a balance between lubrication and structure. High-molecular-weight HA (HMW-HA) excels in viscoelasticity and water retentive properties. Each of the molecular weight forms has something special to offer—no one “best” one, merely the best for a given purpose. Each has a specific molecular weight range suited to a specific medical application and functional requirement.

The next table provides a working comparison of HA’s properties demanded and molecular weight associated for various medical applications:

This structured comparison serves as a reference for clinical decision-making or product development, emphasizing that optimal HA selection depends on specific medical requirements.

[i] Belluco C, Meggiolaro F, Pressato D, Pavesio A, Bigon E, Donà M, Forlin M, Nitti D, Lise M. Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel. J Surg Res. 2001 Oct;100(2):217-21. doi: 10.1006/jsre.2001.6248. PMID: 11592796.

[ii] Jiang D, Liang J, Noble PW. Hyaluronan as an immune regulator in human diseases. Physiol Rev. 2011 Jan;91(1):221-64. doi: 10.1152/physrev.00052.2009. PMID: 21248167; PMCID: PMC3051404.

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What is Hyaluronic Acid

Hyaluronic acid (Hyaluron, HA) is a naturally occurring polysaccharide molecule found in humans and other organisms. It is widely distributed in the human body, primarily present in the skin, joint fluid, eyes, and connective tissues.

HA Structure

The basic structure of hyaluronic acid consists of two types of sugar molecules arranged alternately:

• D-Glucuronic Acid (GlcA)
• N-Acetyl-D-Glucosamine (GlcNAc)

These two monosaccharides are alternately connected with β-1,3 and β-1,4 glycosidic linkages to disaccharide repeating units. This specific linkage allows HA to possess a linear, unbranched conformation, which avoids branching and complex three-dimensional arrangements, ensuring its high water capacity and fluidity. The carboxyl and hydroxyl groups provide opportunities for HA chemical modification. Hence, it can be synthesized into various hydrogels, fillers, and biomedical materials for various applications.

Fig 1. Hyaluronan hydrophilic properties[1]

HA Physiological Functions

As mentioned earlier, hyaluronic acid exists in tissues such as the skin, joints, and eyes in the human body, where it performs important functions:

• Skin: Protects the moisture and elasticity of the skin, softens wrinkles, and delays aging.
• Joints: Lubricates joints, reduces friction, and alleviates arthritis symptoms.
• Eyes: Aids in maintaining the shape and lubrication of the eyeball.

Besides this, hyaluronic acid also serves an important physiological function of wound healing.

Why Hyaluronic Acid Can Heal Wounds

Hyaluronic acid is naturally present in the human body. Endogenous HA and exogenous HA are chemically extremely close. Therefore, the application of hyaluronic acid products in wound healing reduces immune system recognition and rejection reactions. Furthermore, HA is a biodegradable compound, which is degraded by hyaluronidases over time, preventing the accumulation and potential toxicity of the compound in the body. In general, hyaluronic acid is safe, non-toxic, and bio-metabolizable, providing the foundation for it to act as a material in wound healing.

Of course, biocompatibility is just a foundation; the important thing is that hyaluronic acid plays in a number of different functions during the wound healing process through various mechanisms.

Fig 2. Wound healing process[2]

1. Hemostasis

Hemostasis is the first step in wound healing. The mechanism of hemostasis is to stop bleeding by platelet aggregation and blood clotting, sealing the wound from infection. HA can bind to CD44 receptors on the platelet surface, promoting platelet activation and aggregation, and blood clot formation. In addition, HA’s high molecular weight and viscoelasticity allow it to form a viscous physical barrier on the wound surface, restricting blood loss.

2. Inflammatory Phase

During this phase, inflammatory mediators are released so that leukocytes and other immune cells can migrate into the wound site. They suppress infection, debride the wound, and create good conditions for tissue repair and regeneration. During this phase, the primary role of HA is to induce the migration and proliferation of inflammatory cells. While this increases the inflammatory response, exogenous HA also has anti-inflammatory activity. Some studies show that exogenous HA has been found to reduce the infiltration of inflammatory cells and decrease the inflammatory response. In conclusion, HA guarantees the wound healing is enhanced by the optimal amount of inflammation.

3. Proliferation Phase

The proliferation phase is the critical phase of healing wounds, including angiogenesis, epithelial cell migration and proliferation, and repair of extracellular matrix. During this phase, HA plays a range of roles:

• Promotes Cell Migration and Development: HA triggers fibroblast and epithelial cell proliferation, enabling the wound to close rapidly.
• Promotes Angiogenesis: HA stimulates the growth of new blood vessels to supply new tissue with oxygen and nutrients.
• Enables Extracellular Matrix Development: HA stimulates the production of collagen, reconstitutes tissue structure, and enhances wound strength.
• Retains the Wound Moist: HA keeps the wound in a moist state to enable cell functioning and infection prevention, thereby accelerating healing.

4. Remodeling Phase

The remodeling stage is the final phase of the healing process. In this stage, HA takes part in control of reorganization of collagen to make tissue tougher and elastic as well as preclude scar formation. The previously mentioned anti-inflammatory properties of HA continue to play a role in this phase. It can reduce local inflammation in the wound, promoting the recovery of healthy tissue. Moreover, HA can also promote the synthesis of elastin. With the support of elastin, the healed skin experiences less tightness, restoring its original elasticity and flexibility.

What are the Hyaluronic Acid-Based Dressings

Given the powerful healing property of hyaluronic acid, how can researchers disregard it? Its most common applications are HA-based dressings.

Hyaluronic acid dressings are medical wound-covering agents composed of sodium hyaluronate (sodium salt of HA) that provide an extremely conducive microenvironment for wound repair. They can also be blended with other substances, such as antimicrobial silver ions, collagen, chitosan, etc. Depending on the applications, they exist in various forms.

Fig 3. Hyaluronic Acid-Based Dressings[3]

1. Hyaluronic Acid Hydrogel Dressings

Hyaluronic acid hydrogels are the most advanced and versatile type of HA dressings. They are formed through physical or chemical crosslinking, yielding a three-dimensional network hydrophilic gel. They provide a stable moist environment, allowing cell migration and growth. Stable hyaluronic acid hydrogels, for example, can be formed by carbodiimide hydrochloride and adipic dihydrazide crosslinking.

* Suitable for chronic ulcers and burns.

2. Hyaluronic Acid Sponge Dressings

These are highly porous, absorbent dressings. Like a sponge, they are able to suck out excess exudate and prevent maceration. They provide physical support as well, which prevents overgrowth of granulation tissue. They are some of them are mixed with chitosan to enhance antibacterial activity.

* Suitable for highly exudative wounds and postoperative bleeding wounds.

3. Hyaluronic Acid Film Dressings

The most significant benefit of film dressings is their thinness and breathability. With a thickness as low as 0.01~0.1mm, they provide excellent breathability. They are also convenient to apply, sticking to the wound surface without needing secondary fixation.

* Suitable for minimally invasive facial surgeries.

4. Hyaluronic Acid Sprays

These are dressing items that trap sodium hyaluronate in liquid form in pressurized cans or pump bottles, which are applied directly to the skin or wound surface as a spray. Their key features include ease of use, immediate moisturization, and rapid film formation. Medical sprays can also be employed to deliver antibiotics or cytokines for selective drug delivery.

* Suitable for large-area burns and oral/nasal mucosal ulcers.

Other than these traditional dressings, with technology increasing, the market also launched 3D-printed custom dressings. These use a bio-ink composed of HA and fibroblasts to print active dressings with precise matching of the wound contour. They can replicate complicated wounds in a very accurate manner, for instance, nasal defects repair.

Stanford Chemicals Company (SCC) offers high-quality hyaluronic acid (HA) powder raw materials suitable for the pharmaceutical, cosmetic, and research industries. Their HA powder is characterized by high purity, excellent solubility, and a variety of molecular weight options, ensuring outstanding performance across different applications. Whether you need it for moisturizing formulations, injectable fillers, eye drops, or medical dressings, SCC can meet your requirements. For more product information, contact professionals through the Get A Quote.

[1] Frenkel JS. The role of hyaluronan in wound healing. Int Wound J. 2014 Apr;11(2):159-63. doi: 10.1111/j.1742-481X.2012.01057.x. Epub 2012 Aug 14. PMID: 22891615; PMCID: PMC7950635.

[2] Polizzi, A.; Leanza, Y.; Belmonte, A.; Grippaudo, C.; Leonardi, R.; Isola, G. Impact of Hyaluronic Acid and Other Re-Epithelializing Agents in Periodontal Regeneration: A Molecular Perspective. Int. J. Mol. Sci. 2024, 25, 12347. https://doi.org/10.3390/ijms252212347

[3] Mariana F.P. Graça, Sónia P. Miguel, Cátia S.D. Cabral, Ilídio J. Correia, Hyaluronic acid—Based wound dressings: A review, Carbohydrate Polymers, Volume 241, 2020, 116364, ISSN 0144-8617, https://doi.org/10.1016/j.carbpol.2020.116364.

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According to its purpose, HA can be divided into cosmetic-grade, food-grade, medical-grade, and injectable-grade. Of them, injectable-grade HA is extensively used in cosmetic surgery, joint therapy, and medical lubrication. How to choose suitable injectable-grade HA according to the particular requirement? Let’s discuss that.

What is Injectable-Grade Hyaluronic Acid

Injection-grade hyaluronic acid represents high-quality HA developed especially for medical and cosmetic injection purposes. It undergoes extensive purification processes to remove impurities and possible allergens, ensuring the following features:

• High Purity: It is of medical-grade quality, thus safe to be injected.
• High Biocompatibility: Very similar in structure to human tissues for maximum safety.
• Long-Lasting Stability: It degrades much more slowly, prolonging its effect.

This kind of HA is used for filling facial hollows, and lubricating joints, and can even enhance the smooth operation of surgical tools.

Key Considerations When Choosing Injectable-Grade Hyaluronic Acid

The key to selecting the right injectable-grade HA lies in understanding your application needs. Of course, we have summarized some core indicators here to help you understand your needs.

1. Molecular Weight

Molecular weight defines the viscoelasticity, absorption rate, and degradation time of HA. Generally speaking, high molecular weight works better for lubrication and support, while low to medium molecular weight serves for penetration and drug delivery.

2. Purity and Sterility

HA injections should have ultra-high purity, be free from impurities, and be manufactured under sterile conditions to minimize infection risk.

3. Biocompatibility

Good quality HA should be strictly tested for compatibility with human tissues to minimize inflammation or adverse reactions upon its use.

4. Certification and Credentials

Only choose products certified by international authorities such as FDA or CE to ensure good quality and safety.

Products meeting this criterion will perform well in the intended applications.

Read more: How is Hyaluronic Acid Powder Made

Suitable Molecular Weights for Different Scenarios

–Cosmetic Procedures

HA is commonly used in cosmetic procedures to fill facial hollows, reduce fine lines, and improve skin elasticity.

Studies have shown that HA with molecular weights in the range of 1,300 kDa–1,800 kDa provides optimal viscoelasticity and volumizing effects, which are crucial for facial contouring and dermal filler applications.[i]

The medium to high molecular weight provides the structural integrity needed to sculpt facial contours while maintaining biocompatibility and longer-lasting effects due to slower degradation rates.

–Joint Injections

For patients with osteoarthritis, HA injections are essential for pain relief and improved joint mobility.

The high molecular weight ensures a thick, viscous solution capable of providing cushioning for joints, mimicking natural synovial fluid.

–Medical Lubricants

HA is often used as a lubricant during surgical procedures to minimize friction between instruments and tissues, improving procedural efficiency.

Medium molecular weight (800 kDa–1,300 kDa) HA is well-documented for its flowability and lubricating properties, essential for reducing friction during surgical procedures.[ii]

Medium molecular weight strikes a balance between being easy to handle and highly effective as a lubricant, making it suitable for surgical applications requiring precise, smooth interactions.

Conclusion

It is easy to select the proper injectable-grade hyaluronic acid once the application scenario is clear. Cosmetic procedures require medium and high molecular weight products for excellent support and longevity of results. High molecular weight HA has better application in joint injections, as it maintains lubrication and cushioning.

Meanwhile, in medical lubricant applications, medium molecular weight HA remains flowable with safety features. Regardless of the application, always prioritize purity, sterility, and certifications to ensure safety and effectiveness.

Pure Injection Hyaluronic Acid (HA) Powder from Stanford Chemicals Company

Injection-grade hyaluronic acid from Stanford Chemicals Company (SCC) is GMP, CEP, and DMF certificated and the factory passed an on-site inspection by the US FDA. It is all fermented products, non-animal sources, non-GMO, and non-BSE/TSE risk.

Main Products:

References:

The 5 Common Uses of Injectable Hyaluronic Acid

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

[i] Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009 Feb;35 Suppl 1:302-12. doi: 10.1111/j.1524-4725.2008.01046.x. PMID: 19207319.

[ii] Cowman MK, Schmidt TA, Raghavan P, Stecco A. Viscoelastic Properties of Hyaluronan in Physiological Conditions. F1000Res. 2015 Aug 25;4:622. doi: 10.12688/f1000research.6885.1. PMID: 26594344; PMCID: PMC4648226.

The post How to Choose the Right Injectable-Grade Hyaluronic Acid appeared first on Stanford Chemicals.

Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with repeating disaccharide units of D-glucuronic acid and N-acetylglucosamine. Its salt form, sodium hyaluronate (SH), was initially isolated from the eye’s vitreous body. Sodium hyaluronate has a wide distribution in animal or human tissues, generally located in the extracellular matrix. It has a high concentration in the vitreous humor, aqueous humor, synovial fluid, skin, and umbilical cord.

Sodium hyaluronate is known for its excellent viscoelasticity, unique rheological properties, pseudoplasticity, non-toxicity, and superior biocompatibility.

Fig 1. Artificial tears with hyaluronic acid as the main ingredient

Basis for Sodium Hyaluronate in Ophthalmology Applications

It is highly moisturizing. Sodium hyaluronate can bind water several hundred times its weight, maintaining the ocular surface moisture balance. Its viscoelastic nature allows it to form a stable film on the eye surface, providing lubrication and protection while reducing friction.

As a natural constituent of human tissues, sodium hyaluronate possesses excellent biocompatibility with minimal risk of rejection or irritation. Furthermore, it provides an enhancement in corneal repair and regeneration, reduces inflammation, and soothes discomfort due to environmental stimuli or surgical procedures.

Given these properties, sodium hyaluronate is widely used in ophthalmic products such as artificial tears, surgical viscoelastic fillers, ophthalmic injectables, and corneal repair agents. Its applications range from routine eye care to advanced surgical procedures.

Fig 2. Viscoelasticity of hyaluronic acid

Applications of Sodium Hyaluronate in Eye Health

The uses of sodium hyaluronate in ophthalmology can be roughly divided into two categories. There is ophthalmic viscoelasticity, mainly used in all sorts of ophthalmic surgeries including glaucoma and cataract surgery; another one is eye drops, mainly used in treating dry eyes and corneal burns.

1. Ophthalmic Viscoelastic Agents

1.1 Role in Surgery

Sodium hyaluronate is used as a viscoelastic agent in many eye surgeries. It has a high molecular weight and excellent viscoelasticity, providing mechanical protection for the surgery to take place. Therefore, it maintains structure and prevents tissue collapse or damage caused by surgical instruments.

• Glaucoma Surgery

Sodium hyaluronate protects intraocular tissues, maintains the shape of the anterior chamber, and reduces friction and damage from surgical tools, thus enhancing safety.

• Cataract Surgery

It acts to safeguard the cornea endothelium and to serve as an aid to the implantation of an intraocular lens. It provides a clearer surgical field and minimizes mechanical trauma to the cornea during surgery.

• Trauma Repair Surgery

Sodium hyaluronate serves as a lubricant for the surgical procedure in ocular traumatized patients, inhibits the adhesion of tissues, and provides an optimal environment for healing after surgery.

• Corneal Laser Surgery

The protective film helps prevent excessive drying of tissues and reduces mechanical irritation from surgical instruments.

1.2 Recovery Post-Surgery

Sodium hyaluronate after surgery promotes the repair of tissues, reduces inflammation, and speeds up healing. It keeps the environment moistened to reduce any discomfort for the patients in recovery.

2. Eye Drops

Sodium hyaluronate is used in eye drops for moisturizing and lubrication, relieving dry eyes, protecting the ocular surface, and promoting corneal repair. It is suitable for sensitive people and postoperative care.

2.1 Treatment for Dry Eye

Dry Eye is a chronic condition caused by insufficient tear production or excessive evaporation, leading to symptoms such as dryness, fatigue, and a foreign body sensation. Sodium hyaluronate excels in treating dry eye due to its strong moisturizing properties.

• It forms a uniform protective film on the ocular surface, enhancing tear film stability and preventing tear evaporation.
• Its high water retention alleviates dryness and improves patient comfort.
• It enhances the repair ability of ocular surface cells, preventing more severe damage caused by chronic dryness.

2.2 Corneal Burn Repair

Sodium hyaluronate plays a vital role in treating corneal burns, where the cornea experiences water loss, cell damage, and inflammation. It helps in several ways:

• Moisturizing and Lubricating
• Promoting Cell Regeneration
• Reducing Inflammation

2.3 Daily Eye Care

Sodium hyaluronate-based eye drops are also widely used for daily eye care, especially by individuals who use electronic devices for extended periods or wear contact lenses. These drops effectively relieve discomfort caused by eye strain or insufficient tears, providing long-lasting hydration and lubrication.

Product Recommendations

Stanford Chemical Company (SCC) is one of the leading US-based wholesalers of hyaluronic acid, offering a range of pure hyaluronic acid powders in medical, food, cosmetic, and injectable grades. These cover high, medium, and low molecular weights and also support customization.

The main products in eye health:

References:

Sodium Hyaluronate Used in Anterior Segment Eye Surgery

Hyaluronic Acid: The Ultimate Moisturizer for Dry Eyes

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Polyglutamic Acid in Skincare: High-Efficiency Moisturizer

γ-PGA is capable of absorbing 5,000 times its weight in water; thus, it is much more effective in moisture retention compared to hyaluronic acid. It further forms a thin film on the surface of the skin to prevent water loss. In fact, one such study shows that this protecting layer may reduce water evaporation by about 10% to 20%. Besides, γ-PGA promotes the renewal of keratinocytes, reducing the impact of external irritants on the skin.

Table 1. Comparison of the skin care functions of polyglutamic acid with hyaluronic acid and collagen

Reference: Polyglutamic Acid: A “Better Alternative” to Hyaluronic Acid for Moisturizing Power

Polyglutamic Acid in the Food: Antioxidant for Extending Shelf Life

Non-toxic and tasteless, polyglutamic acid has functions of water retaining and thickening. It is mainly used in bakery products as a thickener and moisturizer, enhancing the taste of food. γ-PGA impairs starch aging by 20% to 30% and keeps the food soft and fresh. It enhances calcium absorption, increasing about 40% when combined with γ-PGA[i]. Being so, it is used worldwide in quite several functional foods and health aids. Besides, γ-PGA can increase the flavor of food and make dishes more attractive. If you enjoy eating fried foods, then consider adding gamma -PGA as it reduces body fat buildup.

Table 2. Applications and benefits of polyglutamic acid in foods

Polyglutamic Acid in Agriculture: The Soil Conditioner

Polyglutamic acid is a very effective conditioner for the soil and an additive to fertilizers. It improves the structure of the soil very much. Studies have shown that γ-PGA may increase the water retention of the soil by about 30% to 40%[ii], which keeps the water in the soil for longer and reduces crop stress due to drought. Besides, it accelerates the activities and reproduction of microorganisms, which increases the flow of nutrients in the soil.

Added to fertilizers, γ-PGA increases the utilization rate of fertilizers’ nutrients by 10%-15% and increases crop yield. It also enhances resistance to stress in plants, including those caused by pests and diseases. When γ-PGA is introduced into the soil, it forms a thin film on the root hair surface. This membrane protects not only the root hairs themselves but also serves as an interface for effective nutrient-water exchange to enable better nutrient absorption.

Polyglutamic Acid in Water Treatment: Natural Heavy Metal Adsorbent and Flocculant

It can function as an adsorbent of heavy metal ions and a flocculant. Its application in water treatment is mainly based on its strong heavy metal chelation and flocculation properties. For example, studies have shown that γ-PGA can realize more than 90% chelation efficiency for lead, cadmium, and mercury ions, which can significantly reduce the content of heavy metals in the water. Besides, compared with general flocculants, as a natural flocculant, γ-PGA is 20% to 25% more efficient in the removal of suspended solid and organic pollutants from water.

Polyglutamic Acid in the Medical Field: Promote Drug Delivery

In the field of medicine, γ-PGA is extensively used in drug delivery systems because it possesses excellent biocompatibility and biodegradability. According to some research, the carriers based on γ-PGA could prolong the time of drug release from 3 to 5 times and accordingly enhance the therapeutic effect. It can also be applied in surgical sutures and dressings of wounds.

During the process of degradation, there is no toxic by-product of γ-PGA, reducing inflammation and problems of infection caused after surgery. It seems that studies have shown that γ-PGA in repairing bone and other materials can increase bone tissue regeneration; the speed of bone healing can be accelerated by 15% to 20%.

Conclusion

Due to all these different applications of PGAs in skin care, food, agriculture, water treatment, and medicine, they can be considered one of the most versatile, safe, and promising natural biomaterials with huge perspectives for their applications in the future.

Stanford Chemical Company (SCC) has over 16 years of experience in manufacturing and marketing phytochemicals, pharmaceutical intermediates, catalysts, laboratory equipment, and a variety of specialty fine chemicals. The company offers a variety of skin care ingredients (polyglutamic acid, hyaluronic acid, collagen, etc.), food additives, feed additives and more. For more information, you can visit our homepage or use the search box to find the product you need.

[i] Yang, Li-Chan & wu, Jinbin & Ho, Guan-Huei & Yang, Shih-Ching & Huang, Yun-Pen & Lin, Wen-Chuan. (2009). Effects of poly-gamma-glutamic acid on calcium absorption in rats.. Bioscience, biotechnology, and biochemistry. 72. 3084-90. 10.1271/bbb.80024.

[ii] Zhang L, Yang X, Gao D, Wang L, Li J, Wei Z, Shi Y. Effects of poly-γ-glutamic acid (γ-PGA) on plant growth and its distribution in a controlled plant-soil system. Sci Rep. 2017 Jul 20;7(1):6090. doi: 10.1038/s41598-017-06248-2. PMID: 28729559; PMCID: PMC5519684.

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History of Hyaluronic Acid

In 1934, scientists Karl Meyer and John Palmer first isolated HA from the vitreous of cow eyes, discovering its unique moisturizing and lubricating properties. HA’s medical applications began over 70 years ago. Using time as a clue, we can clearly see the application history of hyaluronic acid.

• 1934 – HA was first isolated.
• 1930s-40s – HA was extracted from synovial fluid, skin, umbilical cords, tumors, and rooster combs.
• 1940s-50s – HA began to be used in medicine and eye surgeries, especially in cataract treatments.
• 1951 – The chemical structure of HA was determined.
• 1970s – Cartilage proteoglycans were found to interact specifically with HA.
• 1980s – HA was widely used to treat arthritis and introduced into cosmetics and skincare.
• 1993 – Hyaluronate synthase was discovered and cloned from Group A streptococcus.
• 1999 – The first purification of active HA synthase.
• Today – HA is mainly produced through bacterial fermentation, an efficient and eco-friendly method widely applied in pharmaceuticals, skincare, and biotechnology.

Medical Value of Hyaluronic Acid

Hyaluronic acid has a wide range of applications in the medical field: cell proliferation and differentiation, regulation of inflammation, vascular generation, and treatment of tumor cancer.

Fig 1. Benefits of Medical-Grade HA

1. Promoting Cell Proliferation and Differentiation

HA is an important substance in cell proliferation and differentiation. As an essential component of the ECM, HA could create a proper microenvironment for cell regeneration to help in wound healing and repair of cartilage tissue. For example, HA enhances chondrocyte cell proliferation, which is very effective in cartilage regeneration and also in the functional recovery process.

2. Modulating Inflammation

HA is an important mediator in the regulation of inflammatory processes. It may modulate the activity of immune cells, thereby reducing excessive inflammation, which may prevent tissue damage. In this respect, intra-articular injections of HA may reduce pain and improve functional ability in certain clinical conditions such as osteoarthritis. It reduces inflammation during the healing of skin wounds and hence promotes tissue repair.

3. Enhancing Vascular Generation

HA contributes to the process of angiogenesis-or, new blood vessel formation-which is important in processes such as wound healing and tissue regeneration and some pathologies such as tumor growth. HA functions through interaction with its receptors to enhance migration and proliferation of endothelial cells and, thus, hastens vascular formation. This mechanism not only helps accelerate wound healing, but can also play a positive role in certain therapeutic areas, such as the treatment of ischemic diseases.

Read more: Top 10 Benefits of Hyaluronic Acid

4. Cancer Cells Inhibition

HA has been in focus in application to cancer treatment. In the case of low molecular weight HA, Exogenous LMW-HA may exert anti-tumor effects by directly triggering an immune response, decreasing the proliferation of tumor cells, or remodeling the tumor microenvironment. Though partially unclear, Exogenous LMW-HA has been proposed to interact with specific immune cells and interfere with tumor cell signaling. More recently, HA has been suggested for application in improving the diagnosis of cancer and as part of targeted drug delivery systems, offering higher specificity in cancer treatments.

Reference: Does Hyaluronic Acid Cause Cancer

Table 1. Overview of the medical value and application of hyaluronic acid

Biomedical Products Based on HA

Due to its biocompatibility, biodegradability, non-toxic, and non-immunogenic properties, several biomedical products have been developed based on HA:

• Injectables: Used for skin fillers, joint lubrication, and anti-aging treatments, such as facial fillers and joint injections.
• Oral Supplements: Often used to improve skin hydration, quality, and joint health.
• Drug Delivery Systems: HA serves as a carrier for slow drug release, improving absorption and bioavailability at specific sites.
• Ophthalmic Solutions: Such as artificial tears and corneal repair solutions, used to alleviate dry eyes and promote corneal healing.
• Wound Dressings: HA promotes wound healing and is used in treating burns, ulcers, and other injuries.
• Bone Tissue Engineering Materials: Used to promote bone and cartilage regeneration.
• Contact Lens Lubricants: Provides comfort and relieves dryness for contact lens wearers.

Fig 2. Biomedical Products Based on HA

Conclusion

As a biocompatible and biodegradable compound, HA holds immense potential as a bioactive molecule for various physiological and pathological conditions. Its applications span from skincare benefits to cancer treatment, inflammation regulation, and chronic disease management. With advancing technology, we can expect more efficient production processes and innovative therapeutic products in the future.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

List of Medical-Grade Sodium Hyaluronate Powder：

• HA-EM2.0-SC
• HA-EM2.4-SC
• HA-EM3.0-SC

Reference:

Iaconisi, G.N.; Lunetti, P.; Gallo, N.; Cappello, A.R.; Fiermonte, G.; Dolce, V.; Capobianco, L. Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review. Int. J. Mol. Sci. 2023, 24, 10296. https://doi.org/10.3390/ijms241210296

The post Exploring the Medical Value of Hyaluronic Acid (HA) appeared first on Stanford Chemicals.

Hyaluronic acid (HA) plays an important role in the human body. It is widely used in various fields, such as skin care, relieving joint pain, wound healing, and lubrication in eye surgeries.

No exaggeration, Hyaluronic Acid has become one of the most popular active ingredients in cosmetic formulations today. Its exceptional moisturizing and anti-aging properties have made it highly sought after in the beauty industry. Both professionals and consumers are intrigued by how HA helps rejuvenate the skin and maintain its health. This article provides a comprehensive summary of the benefits and applications of HA in beauty.

Fig 1. Wide application of HA

Benefits of HA: A Natural Moisturizer and Repair Agent

Hyaluronic acid holds a key position in beauty due to its unique properties. Its main benefits include:

• High Moisture Retention: Effectively absorbs and locks in moisture, keeping the skin hydrated.
• Viscoelasticity: Forms a soft and elastic film that reduces moisture loss.
• Biocompatibility: Naturally compatible with the skin, reducing the risk of allergic reactions.
• Non-immunogenic: Unlikely to cause immune responses, suitable for all skin types.

Moreover, hyaluronic acid has significant effects on reducing inflammation, promoting skin regeneration, and fighting aging. These characteristics make it a key ingredient in anti-aging products. The different effects of hyaluronic acid depend on its molecular weight. As shown in the figure 2.

Fig 2. Different effects of high, medium, and low molecular weight HA[1]

Read more: Top 10 Benefits of Hyaluronic Acid

Hyaluronic Acid in Skincare and Beauty

Hyaluronic Acid is widely used in beauty products, ranging from daily skincare to professional aesthetic treatments.

Fig 3. Cosmetic and nutricosmetic effects of HA.

–Moisturizing Products

HA’s superior moisturizing ability makes it a core ingredient in many hydrating products. Its high moisture absorption helps draw and lock water from the environment, keeping the skin hydrated. In products like creams, serums, and lotions, HA forms a thin film on the skin’s surface, reducing moisture evaporation and leaving the skin soft and smooth. This moisturizing effect is especially suitable for dry skin or dry environments.

–Anti-aging Products

Hyaluronic Acid is extensively used in anti-aging products. As we age, the natural HA in our skin decreases, leading to moisture loss, reduced elasticity, and wrinkles. Anti-aging products containing HA (like wrinkle creams and serums) help restore moisture and reduce the appearance of fine lines and wrinkles. Different molecular weights of HA work at various skin layers—low molecular weight HA penetrates deeply, improving elasticity and firmness, while high molecular weight HA forms a protective barrier to reduce water loss.

–Sunscreen Products

In sunscreens, Hyaluronic Acid not only enhances the moisturizing effect but also protects the skin from UV damage through its antioxidant properties. UV rays accelerate skin aging, but HA helps neutralize free radicals, slowing the aging process. Additionally, HA in sunscreens improves skin smoothness and texture, keeping the skin soft even after sun exposure.

–Injectable Fillers in Aesthetic Medicine

Hyaluronic Acid is widely used as an injectable filler in aesthetic medicine. HA injections fill facial wrinkles, nasolabial folds, and sunken areas, instantly enhancing facial contours and reducing signs of aging. This non-surgical cosmetic treatment is popular due to its safety, short recovery time, and natural results. Furthermore, HA injections stimulate collagen production, making the skin firmer and more elastic.

–Wound Healing and Skin Repair

Hyaluronic Acid’s healing properties make it an essential ingredient in wound care and skin repair products. Its powerful moisturizing ability keeps wounds moist, aiding tissue regeneration and minimizing scar formation. HA also has anti-inflammatory properties, helping reduce skin irritation and inflammation, and speeding up the healing process. In beauty products, HA is often added to repair creams to help restore damaged skin and alleviate irritation caused by sun exposure, acne, and other skin issues.

Read more: Hyaluronic Acid Powder: The Acne-Prone Skin Savior

Conclusion

With its diverse functions and outstanding effectiveness, HA has become an irreplaceable ingredient in the beauty industry. From daily skincare to professional aesthetic treatments, HA consistently demonstrates its excellent moisturizing, anti-aging, and repair capabilities. As technology advances, the application of HA in beauty will continue to expand, bringing more possibilities for skin health and beauty.

Stanford Chemicals Company (SCC) is a professional supplier of hyaluronic acid. SCC offers high-purity, high-quality, and safe sodium hyaluronate powder (including food-grade, cosmetic-grade, medical-grade, and injectable-grade). All of SCC’s hyaluronic acid products are made using the bacterial fermentation method, ensuring safety and reliability.

List of Cosmetic-grade Sodium Hyaluronate Powder：

• HAC-Micro-SC
• HAC-Oligo-SC
• HAC-N-SC
• HAC-L-SC
• HAC-M-SC
• HAC-H-SC

[1] Juncan, A.M.; Moisă, D.G.; Santini, A.; Morgovan, C.; Rus, L.-L.; Vonica-Țincu, A.L.; Loghin, F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules 2021, 26, 4429. https://doi.org/10.3390/molecules26154429

The post Comprehensive Summary: The Application of Hyaluronic Acid in Beauty appeared first on Stanford Chemicals.

The Mechanism of Chondroitin Sulfate

Chondroitin sulfate is a naturally occurring substance found in the cartilage of the human body. Its primary function is to help maintain the elasticity and hydration of cartilage. Healthy cartilage is essential for the normal functioning of joints, as it reduces friction during joint movement and absorbs shock, thus protecting the bones from damage. Structurally, chondroitin is similar to glycosaminoglycans, which play a crucial role in the matrix of cartilage by providing both structure and support.

Chondroitin (Ch) works by absorbing water, maintaining the elasticity and lubrication of cartilage. When the level of chondroitin decreases, cartilage can become fragile and lose its normal function, worsening arthritis symptoms. The theory behind supplementing with Ch is to increase the concentration in the joints, improve cartilage quality, and, as a result, relieve pain and stiffness.

Video: Chondroitin Sulfate For your Joint

Clinical Research Evidence

Despite its widespread use in joint health supplements, the effectiveness of Ch remains a topic of debate in the scientific community. Numerous clinical studies have been conducted to evaluate its impact on arthritis, but the results are not entirely consistent.

Some early studies suggested that chondroitin possesses anti-inflammatory properties, reducing joint pain and improving function. For instance, a study published in 2007 found that chondroitin sulfate significantly reduced pain scores in patients with knee osteoarthritis and improved their ability to move. These findings provided theoretical support for the use of chondroitin and prompted more people to try it as a supplement.

However, more recent large-scale randomized controlled trials have produced mixed results. One such study, funded by the National Institutes of Health (NIH) and known as the GAIT (Glucosamine/Chondroitin Arthritis Intervention Trial), found that the combination of chondroitin and glucosamine did not show significant benefits for patients with mild to moderate osteoarthritis. However, in patients with more severe osteoarthritis, the combination appeared to provide some relief. This result sparked widespread discussion about the effectiveness of Ch among both academics and the general public.

Fig 1. Chondroitin sulfate powder

Why the Inconsistent Results

The varying results across different studies could be attributed to several factors. First, the effectiveness of Ch may depend on the severity of the patient’s condition. In some studies, participants may have had relatively mild arthritis, where the cartilage damage was not yet pronounced. As a result, supplementing with chondroitin sulfate may not have produced significant effects. In contrast, in studies involving patients with more advanced arthritis, where cartilage was more severely damaged, chondroitin may have had a more noticeable impact.

Second, differences in study design and methodology could also explain the inconsistent results. Factors such as the dosage of Ch, duration of use, and whether it was combined with other supplements or medications all influence the outcome. Additionally, the quality and formulation of chondroitin supplements vary between products, potentially affecting their efficacy.

Fig 2. Chondroitin sulfate structure and the benefit of shock absorber

Considerations for Using Chondroitin

Although some studies have shown improvements in arthritis symptoms with Ch, it is essential to approach its use with caution. First, chondroitin sulfate is not a quick fix. According to clinical research, it may take at least three months of consistent use before noticeable results are observed. Therefore, individuals looking for fast pain relief may find chondroitin insufficient on its own.

Secondly, while chondroitin is generally considered safe, some mild side effects have been reported, such as gastrointestinal discomfort, nausea, and diarrhea. Furthermore, chondroitin may interact with certain medications, particularly blood thinners. Thus, it is advisable to consult with a healthcare professional before starting chondroitin sulfate, especially for individuals taking other medications.

Is Chondroitin Right for You

Chondroitin may offer some benefits for people with arthritis, particularly those with more severe symptoms. However, its effectiveness may be limited in individuals with mild osteoarthritis. If you are considering using Ch to relieve joint pain, it’s crucial to assess your specific condition, including the severity of your arthritis, your treatment goals, and the potential for side effects. A discussion with your doctor can help you make an informed decision about whether long-term use of chondroitin is appropriate for you.

Read more: Hyaluronic Acid VS. Glucosamine VS. Chondroitin: Which Is Best for Joints?

Other Ways to Manage Arthritis

In addition to chondroitin, managing arthritis often involves a multi-faceted approach. For example, regular exercise can help maintain joint flexibility and muscle strength, reducing stress on the joints. Physical therapy and rehabilitation exercises can also effectively relieve joint pain and improve joint function.

Medications play an important role in arthritis management as well. For patients with more severe pain, nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may be recommended. Injections of hyaluronic acid are also a common method. In recent years, newer biological therapies and disease-modifying drugs have been developed to control the inflammatory response and progression of arthritis.

Conclusion

Chondroitin sulfate, as a natural substance, theoretically helps protect and repair joint cartilage. However, its actual effectiveness varies among individuals, especially in patients with mild to moderate osteoarthritis, where the scientific evidence remains inconclusive. For patients with more advanced symptoms, Ch supplementation may offer some relief. When choosing whether to use chondroitin sulfate or other supplements, it’s important to consider your health condition, consult with a doctor, and adopt a comprehensive approach to managing arthritis to achieve the best possible outcomes.

Stanford Chemicals Company (SCC) has developed the manufacturing and selling of Chondroitin Sulfate for over 16 years. Our products included pharmaceutical-grade and food-grade chondroitin sulfate. The sources are bovine, shark cartilage, etc.

The post Does Chondroitin Sulfate Help with Arthritis appeared first on Stanford Chemicals.

With the rapid development of modern medicine and cosmetic technology, injectable hyaluronic acid is attached importance to in many respects. Being an excellent moisturizer with its biocompatibility, hyaluronic acid has developed a wide scope of applications in the field of structure and function improvement. It plays a central role in skin, joint, and eye care and further in surgical treatment in the field of eye diseases. This article shall focus on the five most common applications of injectable hyaluronic acid and further consider its safety record and possible side effects.

What Is Injectable Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring polysaccharide in the connective tissues of the body, skin, and eyes. It is known to hold up to 1000 times its weight in water; this helps in lubricating and keeping tissues elastic. Other functions of hyaluronic acid are tissue hydration, cell repair, anti-inflammatory, and as a lubricant in joints and in eye surgery. The injectable hyaluronic acid is extracted and purified in a unique way so that it is safe for injection.

–The Benefits of Hyaluronic Acid

• Moisturizing and hydration: It is able to absorb a lot of water and hold it, thereby keeping skin and tissues hydrated and elastic.
• Tissue repair: The very nature of hyaluronic acid promotes cell growth and tissue repair; thus, it creates less scarring after injury.
• Anti-inflammatory and lubrication properties: In joints and eye surgery, this acts to reduce inflammation and friction, thereby protecting tissues from damage.

The 5 Common Uses

Due to above these properties, hyaluronic acid finds wide application in medical and cosmetic treatments alike.

1. Viscosupplementation

Hyaluronic acid is one of the essential elements used in orthopedics as a joint lubricant. In patients who have osteoarthritis, the reduction in the volume of the fluid may increase the friction and thereby result in pain and inflammation.

Hyaluronic acid is administered into the articulation space. And then it increases the viscosity of the fluid within the joint cavity, facilitating lubrication and cushioning. This relieves pains and improves functions, mostly for those suffering from osteoarthritis of the knee, and possibly delays surgical procedures.

Fig 1. Benefits of HA for joints

2. Ophthalmic Surgery Aid

Hyaluronic acid finds applications in ophthalmic surgery, primarily as an intra-ocular filler. Hyaluronic acid facilitates smooth functioning and protects the corneal endothelial cells. In addition, HA can maintain the structural integrity of the eyeball during procedures such as cataract removal or corneal transplants.

At the same time, its high viscosity and elasticity minimize trauma during surgery and allow a much smoother operation. HA further eases recovery from the surgery and reduces post-operative complications.

Fig 2. Ophthalmic Surgery Aid

3. Dermal Fillers

Hyaluronic acid has been one of the finest uses in non-surgical facial treatments as a dermal filler. HA, when injected into the skin, fills in wrinkles and restores volume to the skin, giving the skin elasticity and more radiance. Such products are used in plumping up the lips, smoothing out nasolabial folds, defining cheek bones, and the chin.

The advantage of hyaluronic acid when used as a filling material is that it appears natural and is reversible. That is, the injected substance can be dissolved with an enzyme injection in unsatisfactory results.

Fig 3. Comparison of HA facial filler effects

4. Skin Repair Products

Apart from its cosmetic and surgical uses, hyaluronic acid is used in many skin repair processes. Since hyaluronic acid is injectable, it can enhance the healing process and regeneration of the skin to treat burns, wounds, and other injuries caused after surgery.

It keeps the wounds moist and prevents scabbing. This, in turn, reduces the occurrence of scarring. It can also help sunken scars and improve the overall texture of the skin by filling these depressions.

Fig 4. Wound healing process

5. Low Scarring Cosmetic Fillers

Hyaluronic acid also enjoys wide application in minimally invasive aesthetic treatments. Given its very good modeling properties, combined with safety, it is applied not only to non-surgical aesthetic treatments. For example, nose reshaping, chin contouring, and tear trough filling but also for facial contours.

These treatments are in demand since they have quick results and short recovery time, with the results appearing natural. Hyaluronic acid injections adjust facial contours subtly to create a more personified, pain-free, riskless aesthetic outcome for surgery.

Is Injectable Hyaluronic Acid Safe

Injectable hyaluronic acid is quite safe due to its high compatibility with the body. Most people tolerate it well and do not experience serious adverse reactions after injection, though it may lead to some mild adverse reactions, including reddening, bruising, slight pain, and allergic reactions at the site of injection. However, all of these may be temporary and will subside on their own.

–Side Effects of Injectable HA

Rarely, they can also occur in more severe types, such as infection, nodules or lumps at the injection site, and skin necrosis. More specifically, erroneous injection techniques, particularly for facial filling with hyaluronic acid, may cause vexing complications, such as vascular occlusion. It is hence very important to select an experienced and qualified professional to give the injection and practice stringent sterile techniques in a bid to prevent these complications.

Where to Buy Safe Injectable HA

Stanford Chemical Company (SCC) is specialized in providing tailored molecular weight, injection-grade HAF-C-SC. The injection-grade hyaluronic acid from SCC is GMP, CEP, and DMF certified, and the factory passed an on-site inspection by the US FDA. Our Injection-Grade HA is all fermentation products, of non-animal origin, non-GMO, and non-BSE/TSE risk.

What differentiates our product is the origin. Our pure HA Powder comes just from fermentation processes, thus being completely free of animal sources, non-GMO, and Vegan. The hyaluronic acid thus presents a conscientious choice for those seeking products that are sourced ethically and naturally in tune with values of sustainability and purity.

Recommended products:

• HA-EP1.8-SC
• HA-EP2.4-SC
• HA-EP3.0-SC

Conclusion

Injectable hyaluronic acid is regarded as an important tool in modern medicine and cosmetic treatments due to its excellent biological properties and remarkable versatility. From dermal fillers and joint lubricants to the aid for ophthalmic surgery and minimally invasive fillers in cosmetic procedures, HA has found application in these areas and hence shown its effectiveness in promoting health and beauty. Even though relatively safe, proper injection techniques help assure the best aesthetic result and will limit potential side effects. As advances in technology continue, the scope for which hyaluronic acid is used will expand and offer users ever more possibilities.

Related articles:

Solubility of Hyaluronic Acid in Different Solvents and Its Influencing Factors

High vs. Low Hyaluronic Acid: How Molecular Weight Affects the Efficacy

Top 10 Benefits of Hyaluronic Acid

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