SCC news – Stanford Chemicals https://www.stanfordchem.com Global Supplier of Hyaluronic Acid & Chondroitin Sulfate Wed, 24 Apr 2024 03:13:38 +0000 en-US hourly 1 https://wordpress.org/?v=4.9.18 https://www.stanfordchem.com/wp-content/uploads/2018/08/cropped-STANFORD-CHEMICALS-LOGO-1-32x32.jpg SCC news – Stanford Chemicals https://www.stanfordchem.com 32 32 The Potent Artemisinin from Traditional Chinese Medicine https://www.stanfordchem.com/the-potent-artemisinin-from-traditional-chinese-medicine.html https://www.stanfordchem.com/the-potent-artemisinin-from-traditional-chinese-medicine.html#comments Thu, 25 Jan 2024 08:02:46 +0000 https://www.stanfordchem.com/?p=9504 Introduction: In the realm of traditional Chinese medicine (TCM), the ancient wisdom of herbal remedies has yielded remarkable treasures. One such extraordinary discovery is artemisinin. It is a natural compound derived from the sweet wormwood plant (Artemisia annua). Artemisinin begins from a traditional remedy and grows into a globally acclaimed antimalarial agent. This tale intertwines […]

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Introduction:

In the realm of traditional Chinese medicine (TCM), the ancient wisdom of herbal remedies has yielded remarkable treasures. One such extraordinary discovery is artemisinin. It is a natural compound derived from the sweet wormwood plant (Artemisia annua).

Traditional Chinese Medicines

Artemisinin begins from a traditional remedy and grows into a globally acclaimed antimalarial agent. This tale intertwines ancient healing practices with cutting-edge scientific advancements.

In this exploration, we are going to delve into its historical roots, scientific breakthroughs, and its profound impact on the global fight against malaria.

1.    Historical Roots in Traditional Chinese Medicine:

Artemisinin’s story begins in the rich tapestry of traditional Chinese medicine.

  • The sweet wormwood plant has been used for centuries to alleviate fevers.
  • The earliest records of its use date back to ancient Chinese texts. At that time, practitioners recognized its efficacy in treating symptoms associated with malaria.
  • The plant’s scientific name, Artemisia annua, pays homage to the Greek goddess Artemis. It symbolizes the connection between nature’s healing properties and the divine.

2.    Scientific Breakthroughs:

The true magic of artemisinin came through a convergence of ancient wisdom and modern scientific inquiry.

  • In the early 1970s, Chinese scientist Tu Youyou embarked on a mission to find a cure for malaria. This disease had plagued humanity for millennia.
  • Drawing inspiration from ancient texts, Tu Youyou and her team extracted artemisinin from sweet wormwood. This discovery earned her the Nobel Prize in Physiology or Medicine in 2015.

The breakthrough marked a turning point in the fight against malaria.

  • Artemisinin is a sesquiterpene lactone. It demonstrated unprecedented efficacy against Plasmodium falciparum, the deadliest malaria parasite.
  • Its unique mechanism of action involves the release of free radicals within infected red blood cells, selectively destroying the parasites while leaving healthy cells unharmed.

3.    Global Impact on Malaria Treatment:

Artemisinin and its derivatives are known as artemisinin-based combination therapies (ACTs). They swiftly became the frontline treatment for malaria worldwide. The World Health Organization (WHO) endorsed ACTs as the most effective antimalarial drugs. Such an act stresses their role in reducing mortality rates, particularly in sub-Saharan Africa where malaria poses a significant health burden.

The global impact of artemisinin extends beyond its direct antimalarial properties. The compound sparked renewed interest in the exploration of natural products for drug discovery. Researchers got inspiration consequently to delve into traditional healing practices in search of novel therapeutic agents.

Challenges and Resistance:

Despite its remarkable success, the magic of artemisinin faces challenges.

  • Prolonged use in monotherapy has led to the emergence of resistant strains of the malaria parasite. This situation threatens the efficacy of artemisinin-based treatments.
  • Researchers are actively addressing this concern through the development of combination therapies and innovative strategies to combat resistance. Their efforts ensure the continued effectiveness of artemisinin in the global fight against malaria.

Beyond Malaria: Exploring Artemisinin’s Potential:

Artemisinin’s enchantment goes beyond its role in malaria treatment.

–Potential Cancer Treatment:

Artemisinin is now emerging as a promising candidate in the fight against various cancers. This traditional Chinese medicine has the potential as a versatile therapeutic agent.

Recent studies have delved into the compound’s cytotoxic effects on cancer cells. It is reported that artemisinin has the ability to induce apoptosis or programmed cell death. This unique mechanism of action has sparked keen interest in its application across different cancer types.

  • In a notable study published in the journal “Cancer Letters,” researchers investigated the impact of artemisinin on human lung cancer cells. The findings revealed that this traditional Chinese medicine significantly inhibited cancer cell growth and induced apoptosis. Such discovery offers valuable insights into its potential as an anti-cancer agent.
  • Similarly, research in breast cancer models has shown promising results, indicating that artemisinin may play a role in suppressing the proliferation of breast cancer cells.

Related reading: Artemisinin Treats Malaria and Cancer

–Fighting against Infectious Diseases:

Beyond its anticancer properties, artemisinin has exhibited efficacy in addressing other infectious diseases, including schistosomiasis and leishmaniasis. In a clinical study focused on schistosomiasis patients, artemisinin-based therapy demonstrated notable reductions in parasite load and improved clinical outcomes.

Artemisinin’s multifaceted properties make it a subject of exploration in diverse medical fields. The anti-inflammatory and immunomodulatory effects of this traditional Chinese medicine add to its appeal as a potential therapeutic intervention.

Ongoing research continues to unravel the full extent of artemisinin’s capabilities, offering hope for new and innovative treatments beyond its initial use in malaria. As the scientific community delves deeper into the complexities of this magic traditional Chinese medicine, its transformative potential across various medical domains underscores its significance in advancing global health outcomes.

Related reading: Artemisinin Defeats Malaria and Other Parasites

Conclusion:

Artemisinin stands as a testament to the bridge between ancient healing practices and modern scientific breakthroughs. From its roots in traditional Chinese medicine to its pivotal role in the global fight against malaria, artemisinin has woven a narrative of innovation and resilience.

As we continue to unveil the magic of this extraordinary compound, the story of Artemisinin serves as an inspiration for future explorations in the realms of natural products and traditional medicine. In a world where the quest for effective treatments persists, artemisinin stands as a shining example of nature’s profound healing potential.

Stanford Chemical Company (SCC) is a notable player in the field of chemical manufacturing and herbal extract distribution. SCC is recognized for its involvement in the production and supply of artemisinin and its derivatives. Send us an inquiry if you are interested.

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Revitalize Your Skincare Routine with Sodium Hyaluronate Powder https://www.stanfordchem.com/revitalize-your-skincare-routine-with-sodium-hyaluronate-powder.html https://www.stanfordchem.com/revitalize-your-skincare-routine-with-sodium-hyaluronate-powder.html#comments Tue, 01 Aug 2023 08:51:17 +0000 https://www.stanfordchem.com/?p=9384 Introduction Skincare is more than just about cleansing and moisturizing; it’s about discovering ingredients that truly transform your complexion. If you’re on a quest for revitalized and youthful-looking skin, look no further than Sodium Hyaluronate Powder. This remarkable ingredient derived from hyaluronic acid has gained immense popularity in the skincare world for its ability to […]

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Introduction

Skincare is more than just about cleansing and moisturizing; it’s about discovering ingredients that truly transform your complexion. If you’re on a quest for revitalized and youthful-looking skin, look no further than Sodium Hyaluronate Powder. This remarkable ingredient derived from hyaluronic acid has gained immense popularity in the skincare world for its ability to deliver deep hydration and rejuvenate the skin. In this article, we’ll explore how Sodium Hyaluronate Powder can revitalize your skincare routine and help you achieve the healthy, glowing skin you desire.

Sodium Hyaluronate Powder

Understanding Sodium Hyaluronate Powder

Sodium Hyaluronate Powder is derived from hyaluronic acid, a naturally occurring substance in the body that holds moisture and keeps the skin hydrated. However, Sodium Hyaluronate Powder takes it a step further. It is a more stable and smaller molecule than hyaluronic acid, allowing for better absorption into the skin. As a result, this powder delivers intense hydration, promoting plump, supple, and youthful-looking skin.

Related reading: Sodium Hyaluronate: Skin Benefits, Products to Use, and More

Benefits of Sodium Hyaluronate Powder in Skincare Routine

Sodium Hyaluronate Powder stands out for its remarkable ability to transform the skin. It possesses both exceptional moisturizing properties and the ability to enhance the skin’s radiance.

–Deep Hydration

Hydration is the foundation of healthy skin, and Sodium Hyaluronate Powder excels in providing intense moisture. Its small molecular size allows it to penetrate deeply into the skin, delivering hydration where it is needed the most. By attracting and retaining water molecules, Sodium Hyaluronate Powder helps plump up the skin, reducing the appearance of fine lines and wrinkles. The result is a complexion that looks hydrated, supple, and youthful.

–Improved Skin Texture

Uneven skin texture can make the skin appear dull and lackluster. Sodium Hyaluronate Powder can help improve the texture of your skin, making it smoother and more refined. As it deeply hydrates the skin, it enhances the natural exfoliation process, helping slough off dead skin cells and revealing fresher, smoother skin underneath. Regular use of Sodium Hyaluronate Powder can lead to a more even, radiant complexion.

–Enhanced Skin Elasticity

Loss of elasticity is a common sign of aging, but Sodium Hyaluronate Powder can help combat this issue. By replenishing moisture levels, it restores the skin’s natural plumpness and firmness. The increased hydration improves the elasticity of the skin, making it appear more supple and resilient. This can help reduce the appearance of sagging skin and promote a more youthful-looking complexion.

–Anti-Aging Effects

Fine lines, wrinkles, and other signs of aging can be a cause for concern. Sodium Hyaluronate Powder has impressive anti-aging properties that can help diminish these visible signs. Its hydrating effects fill in the fine lines, making them appear less prominent. Additionally, by promoting optimal hydration, it can help improve the overall appearance of the skin, making it look smoother and more youthful. Adding Sodium Hyaluronate Powder to your skincare routine can be a game-changer in your fight against aging.

–Versatile Application

One of the great advantages of Sodium Hyaluronate Powder is its versatility in skincare products. It can be easily incorporated into various formulations such as serums, creams, lotions, and masks. Whether you prefer lightweight textures or more emollient formulas, you can find a product containing Sodium Hyaluronate Powder that suits your preferences. This allows you to tailor your skincare routine to your specific needs while reaping the benefits of this powerful ingredient.

Conclusion

In short, Sodium Hyaluronate Powder is a game-changer when it comes to revitalizing your skincare routine. Its deep hydration, skin texture-improving properties, enhanced elasticity, and versatility make it an invaluable addition to any skincare regimen. Incorporate Sodium Hyaluronate Powder into your routine and experience the transformative power it can have on your skin. Get ready to enjoy a revitalized complexion that radiates health and beauty.

Stanford Chemicals Company (SCC) offers reliable and safe Sodium Hyaluronate Powder for your business and research. Our production is strictly managed according to ISO 9001 and GMP standards. There are Sodium Hyaluronate Powders of different molecular weights on our website. Send us an inquiry if you are interested.

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Food Grade Hyaluronic Acid: Is It Worth Trying? https://www.stanfordchem.com/food-grade-hyaluronic-acid-is-it-worth-trying.html https://www.stanfordchem.com/food-grade-hyaluronic-acid-is-it-worth-trying.html#respond Tue, 07 Feb 2023 05:45:14 +0000 https://www.stanfordchem.com/?p=9038 What Is Food Grade Hyaluronic Acid? Hyaluronic acid (HA, or (C14H21NO11) n) is highly hydrating, and it is widely used in the cosmetic industry. It is a polymer of sugar commonly found in human skin, eyes, and joints. All these HA inside keep your body moist, soft, and smooth. A range of hyaluronic acid products […]

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What Is Food Grade Hyaluronic Acid?

Hyaluronic acid (HA, or (C14H21NO11) n) is highly hydrating, and it is widely used in the cosmetic industry. It is a polymer of sugar commonly found in human skin, eyes, and joints. All these HA inside keep your body moist, soft, and smooth.

A range of hyaluronic acid products is used for water retention. According to its different usages, it can be divided into four types: the cosmetic grade, the food grade, the medical grade, and the injection grade. The cosmetic grade is quite popular among beauty lovers, yet the food grade hyaluronic acid is also of great importance thanks to its moisture and anti-aging effect. Here we discuss the benefits, usage, and more of food-grade hyaluronic acid in the article.

food grade hyaluronic acid

Food Grade Hyaluronic Acid

Is Food Grade Hyaluronic Acid Worthwhile?

Absolutely yes. You can easily find food-grade hyaluronic acid content in beverages, vitamins, capsules, and supplements because of the following advantages.

  1. It helps your body and skin lock water inside your body.

The weight of water that HA attracts is more than 1,000 times that of itself. Therefore, you just need to take a tiny amount of HA to give a big drink of water to your skin. In addition, your skin will look refreshing in the long term.

  1. It assists you to fight against aging and other skin problems.

Food-grade hyaluronic acid supplements reduce your skin’s wrinkles and make it more flexible. It also protects your body from harmful elements such as UV rays and environmental pollutants. HA could accelerate cell growth as well.

Related reading: What are the Top Benefits of Micro Hyaluronic Acid for Your Skin?

Is There A Plant-based Hyaluronic Acid?

There are mainly two ways to produce hyaluronic acid: animal sources and fermentation. Stanford Chemicals provide non-animal food-grade hyaluronic acid for supplementation. You can make inquiries to buy quality food grade HA.

  1. Plant-based HA is obtained from microbial fermentation.

This is a method extensively used to make food-grade hyaluronic acid because it is more cost-effective and eco-friendly.

  1. Animal sources were used in the past.

The earliest source to get HA is the combs of roosters, yet it was abandoned for low efficiency and complicated process.

Stanford Chemicals is a supplier of high-purity food-grade hyaluronic acid powder. We ensure that our hyaluronic acid is non-animal and environmental-friendly. Here are the specifications of these products.

Table 1 Specifications of

Food Grade Hyaluronic Acid

Items Specifications
Appearance White or almost white powder or granules
Particle size Pass through a 60-mesh sieve
pH (5mg/mL solution) 6.0-8.0
Bulk density 0.3-0.6g/cm3
Loss on drying ≤10.0%
Ash ≤13.0%
Protein ≤0.1%

 

How to Take Food-Grade Hyaluronic Acid?

Food-grade hyaluronic acid is taken in the form of common food like jelly, dairy, and drinks. You can get this natural humectant from tablets, capsules, and other healthy foods as well.

  1. HA supplementation by mouth could be useful and safe if the dosage is under 200 mg every day.
  2. Remember to talk to a healthcare provider whenever needed.
  3. Besides, the amount of HA used varies. For instance, it is suggested to take 5 mg for one cycle to cure thumb osteoarthritis.

Can You Safely Ingest Hyaluronic Acid?

Yes. Food-grade hyaluronic acid is rather safe for ingestion. The reason is listed as follows.

  1. HA is a substance found in the human body.
  2. Report on the adverse effects of HA is rare.
  3. However, take professional instructions from doctors if needed.
  4. Take caution if you are allergic or pregnant.

Conclusion

Food-grade hyaluronic acid is a natural humectant with numerous applications, and it could attract water to your skin under normal dosage. Hope that you can have a better comprehension of food-grade hyaluronic acid and its usage. Stanford Chemicals have rich experience in the manufacturing and sale of HA. Sodium hyaluronate powder and other derivatives of HA are also available. Check our website to find great food-grade hyaluronic acid products.

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Which Is Better, Hyaluronic Acid or Sodium Hyaluronate? https://www.stanfordchem.com/which-is-better-hyaluronic-acid-or-sodium-hyaluronate.html https://www.stanfordchem.com/which-is-better-hyaluronic-acid-or-sodium-hyaluronate.html#comments Thu, 12 Jan 2023 01:39:12 +0000 https://www.stanfordchem.com/?p=9019 1.   What is hyaluronic acid? Hyaluronic acid (HA, or (C14H21NO11) n) is an important humectant. It is a polymer of disaccharides composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid is an important component of the human intercellular matrix, such as the body’s connective and neural tissues. Hyaluronic acid locks water molecules inside the human body […]

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1.   What is hyaluronic acid?

Hyaluronic acid (HA, or (C14H21NO11) n) is an important humectant. It is a polymer of disaccharides composed of D-glucuronide and N-acetyl glucosamine. Hyaluronic acid is an important component of the human intercellular matrix, such as the body’s connective and neural tissues.

Hyaluronic Acid or Sodium Hyaluronate

Hyaluronic acid locks water molecules inside the human body like skin and joints. It is applied to a variety of fields for its water retention function. HA can also promote cell proliferation and differentiation and remove oxygen-free radicals, so it is generally used to make skin-care products for moisture and anti-aging. Additionally, this humectant is also found in the medical field to treat arthritis and cataract.

Hyaluronic acid is commonly manufactured by industrial synthesis. Stanford Chemicals Company is an experienced supplier of hyaluronic acid of different grades. For more information about HA and related products, please check our website.

2.   What is sodium hyaluronate?

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of sugar, and it is composed of Na-glucoronate-N-acetyl glucosamine. This sodium salt could be found in the extracellular matrix of mammalian connective, neural tissues, and the corneal endothelium.

Sodium hyaluronate is a synonym for hyaluronic acid. In fact, the two terms are often used interchangeably in the skincare field. Sodium hyaluronate can keep moisture and promotes cell growth and renewal as well. This humectant is applied to different beauty products to keep moisture and reduce the effect of aging. It is also used in medical surgeries.  Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier.

Similarly, sodium hyaluronate is obtained from animal tissues or bacterial fermentation. Stanford Chemicals Company provides high-quality sodium hyaluronate within a short lead time.

3.   What are the differences between hyaluronic acid and sodium hyaluronate?

Hyaluronic acid and sodium hyaluronate are both popular choices for cosmetic uses. They are both hydrating and anti-aging. Consumers can find hyaluronic acid and its salt form in many products like serums and creams. They are also applied to oral supplements.

What is the biggest difference? Sodium hyaluronate has a smaller molecular size, which means that it can penetrate the skin better. Other than that, they both offer the same benefits.

They have a slight difference in terms of features.

  • Sodium hyaluronate is more stable than hyaluronic acid. The salt form is a more stable version, and it could resist oxidation for its higher stability.
  • It is easier for sodium hyaluronate to penetrate the skin surface and enhance the skin barrier. Sodium hyaluronate has a lower molecular size, so it could penetrate deeper and provide intense hydration.
  • In short, hyaluronic acid attracts water molecules on the surface, while its sodium salt moist cells deeper. Other than that, they offer the same benefits for beauty lovers.

4.   Can you use hyaluronic acid and sodium hyaluronate together?

Beauty lovers can use hyaluronic acid and sodium hyaluronate together to moisturize their skin. These chemicals are both gentle and highly hydrating. Both ingredients are suitable for all skin types and compatible with other ingredients. Use them together for an intense hydration effect.

Cosmetic products like serums, moisturizers, and facial oil containing hyaluronic acid and sodium hyaluronate  can provide diverse benefits as listed:

  • Hydration Effect: The key benefit of these two chemicals is hydration. They could continuously draw moisture in from the surrounding environment and provide lasting hydration for the skin in the long term.
  • Repairing Effect: They are helpful to protect our body from harmful toxins like UV rays, environmental pollution, and drastic temperature changes.
  • Protective Barrier: In the long term, hyaluronic acid and its sodium salt could form a complex mesh structure and strengthen the protective barrier for the skin. Wrinkles would be reduced and the plump and glowing skin would be obtained.

5.    Conclusion

Hyaluronic acid and sodium hyaluronate nearly represent the same chemical, and the two terms are often used interchangeably in the skincare and medical world. You can use them at the same time for a better hydrating effect. The slight difference is that sodium hyaluronate is more stable and penetrates the surface of the skin more easily than hyaluronic acid.

Stanford Chemicals Company is a pure organic hyaluronic acid wholesale supplier. Hyaluronic acids of medical grade, cosmetic grade, and food grade are available on our website. High molecular weight, middle molecular weight, and low molecular weight sodium hyaluronate are also available. They are applied to a range of fields including food supplements, cosmetics, eye drops, and pharmaceuticals. For more detailed information, please visit our website.

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What are the 4 Types of Sodium Hyaluronate? https://www.stanfordchem.com/what-are-the-4-types-of-sodium-hyaluronate.html https://www.stanfordchem.com/what-are-the-4-types-of-sodium-hyaluronate.html#comments Fri, 25 Nov 2022 03:34:44 +0000 https://www.stanfordchem.com/?p=8983 Types of sodium hyaluronate 1, Medium molecular weight sodium hyaluronate Highly effective in moisturizing and lubricating the skin. 2, High molecular weight sodium hyaluronate Excellent moisturizing and film-forming properties, efficient thickening effect, and enhanced lubricating feeling when applying products. 3, Sodium Oligomeric Hyaluronate Efficient moisturizing and lubricating effect on the skin. Enzymatic cutting process, molecular […]

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Types of sodium hyaluronate

1, Medium molecular weight sodium hyaluronate

Highly effective in moisturizing and lubricating the skin.

types of sodium hyaluronate

2, High molecular weight sodium hyaluronate

Excellent moisturizing and film-forming properties, efficient thickening effect, and enhanced lubricating feeling when applying products.

3, Sodium Oligomeric Hyaluronate

Efficient moisturizing and lubricating effect on the skin. Enzymatic cutting process, molecular weight less than 10000, real transdermal absorption, deep moisturizing, anti-aging, after-sun repair.

4, low molecular weight sodium hyaluronate

Nutritious skin, breathable and moisturizing, will not bring any sticky skin feeling.

Cosmetic-grade sodium hyaluronate application

1. Formulation application

Medium to high molecular HA to enhance the lubrication of the skin
Medium to high molecular HA increases the consistency of the system
Medium-high molecule HA provides an immediate tightening sensation when absorbed quickly
Oligomeric HA for fast transdermal absorption, enhancing product absorption efficiency

2. Moisturizing and anti-wrinkle effects

The moisture level of skin is closely related to the HA content, as we age, the HA content in the skin decreases, making the water retention function of the skin weaken, resulting in wrinkles. Oligomeric HA can penetrate into the dermis and replenish the endogenous HA of the human body. The HA filled in the dermis can promote the targeted growth of collagen and elastin fibers, tighten the skin and delay the aging process.

3. Skin damage repair and prevention effect

HA promotes the regeneration of injured skin by promoting the proliferation and differentiation of epidermal cells.

Advantages of sodium hyaluronate

– Controlled environment

Standardized clean production plants, strict production management processes, and advanced production equipment avoid the introduction of impurities and contamination by pathogenic microorganisms during the production process.

– High purity

The sodium hyaluronate produced by SCC is refined by fermentation and extraction of Streptococcus oryzae as the strain, with high purity and low content of protein, heavy metal, and other impurities.

– Sodium Oligomeric Hyaluronate

We use sodium hyaluronate hydrolase enzymatic digestion to obtain the product with extremely low molecular weight, and the quality reaches the international first-class level, which is the oligomeric sodium hyaluronate with a molecular weight of less than 10,000.

– Aseptic

Medical-grade sodium hyaluronate is produced with injection water and a partially sterile production plant to ensure the production of sterile products with endotoxin below 0.05 EU/mg.

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What Are the Steps in Peptide Synthesis? https://www.stanfordchem.com/what-are-the-steps-in-peptide-synthesis.html https://www.stanfordchem.com/what-are-the-steps-in-peptide-synthesis.html#respond Thu, 13 Oct 2022 07:35:09 +0000 https://www.stanfordchem.com/?p=8932 Chemical synthesis of peptides is a very special branch of organic synthesis, and there are mainly two methods of liquid-phase synthesis and solid-phase synthesis at present. Liquid-phase synthesis is the classical method of peptide synthesis, which generally adopts stepwise synthesis or fragment condensation method. The stepwise synthesis method usually starts from the C’ terminal amino […]

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Chemical synthesis of peptides is a very special branch of organic synthesis, and there are mainly two methods of liquid-phase synthesis and solid-phase synthesis at present.

hyaluronic acid Peptide Synthesis

Liquid-phase synthesis is the classical method of peptide synthesis, which generally adopts stepwise synthesis or fragment condensation method. The stepwise synthesis method usually starts from the C’ terminal amino acid of the chain and adds a single α-amino protected amino acid repeatedly to the increasing amino acid fraction.

Fragment condensation generally starts with rational segmentation of the target sequence into fragments, followed by stepwise synthesis of the individual fragments, and finally condensation of the individual fragments according to the sequence requirements. The advantages of liquid-phase synthesis are that the intermediates can be purified at each step, the physicochemical constants of the intermediates can be obtained, non-amino acid modifications can be made at will, amino acid deletions can be avoided, and the disadvantages are that it is more time-consuming and labor-intensive, etc.

In solid phase synthesis, the carboxyl group of the first natural hyaluronic acid of the target peptide is covalently bonded to the solid phase carrier (resin), and then the amino group of this amino acid is used as the starting point for synthesis, and it is acylated with the carboxyl group of the adjacent amino acid (amino protected) to form a peptide bond.

Then, the amino group of the resin peptide containing these two amino acids is deprotected and reacted with the carboxyl group of the next amino acid, and the process is repeated until the target peptide is formed.

The advantages are that it simplifies the post-processing operation of each reaction step, avoids the loss due to manual operation and material transfer, has a higher yield and can be automated, etc.; the disadvantages are that the intermediate products of each step cannot be purified, a larger amino acid overfeed must be used, the purity of the crude product is not as good as that of the liquid-phase synthesis, and must be purified by reliable separation means, etc.

Liquid-phase synthesis and solid-phase synthesis have their own advantages and disadvantages, and a suitable process should be selected according to the actual needs of the synthesis. Generally speaking, liquid-phase synthesis is more suitable for the synthesis of short peptides; solid-phase synthesis is more suitable for the synthesis of medium and long peptides. Of course, it is also possible to combine the two methods, such as using the liquid phase method to synthesize short peptide fragments and then applying the fragments to the solid phase synthesis.

Both the liquid-phase and solid-phase synthesis are based on the designed amino acid sequence, and the target molecule is obtained by the directional amide bond formation method. Theoretically, this is not complicated, but there are still many factors to be considered for implementation.

In the case of simple amide bond formation between carboxylic acid and amine, the carboxyl group is usually converted into a lively carboxyl derivative (e.g., chloride or anhydride) before interacting with the amine, or a condensation agent is added to the reaction system. However, the formation of amide bonds between amino acids is much more complicated, because each amino acid contains both amino and carboxyl groups.

If the carboxyl group of one amino acid is activated, it can react with the amino group of the same or another amino acid molecule; if several amino acids are mixed together and a condensation agent is added, only a mixture of peptides with many different amino acid orders can be obtained. Therefore, the research of peptide synthesis needs to pay attention not only to the activation method, coupling method, etc. but also to the choice of protection or deprotection strategy.

In the process of peptide synthesis, some heteropeptides with a similar structure to the target peptide will be generated, such as diastereoisomers due to amino acid racemization, deletion peptides due to some amino acids not being attached, and broken peptides due to peptide bond breakage.

Therefore, it is necessary to consider the selection of reliable separation and purification methods to make the purity of the peptides as required. The purification of peptide drugs is usually performed by chromatographic methods, but in some cases, purification methods commonly used in organic synthesis (e.g. recrystallization) may also be applicable.

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What Is the Best Hydrating Primer at the Drugstore? https://www.stanfordchem.com/what-is-the-best-hydrating-primer-at-the-drugstore.html https://www.stanfordchem.com/what-is-the-best-hydrating-primer-at-the-drugstore.html#respond Fri, 24 Jun 2022 02:40:09 +0000 https://www.stanfordchem.com/?p=8738 When it comes to choosing a hydrating primer, there are a few things to keep in mind. First, consider your skin type. If you have oily skin, you’ll want to avoid primers that are heavy or greasy, as they will likely just make your skin look shinier. Instead, look for light, oil-free formulas that won’t clog […]

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When it comes to choosing a hydrating primer, there are a few things to keep in mind. First, consider your skin type. If you have oily skin, you’ll want to avoid primers that are heavy or greasy, as they will likely just make your skin look shinier. Instead, look for light, oil-free formulas that won’t clog your pores. If you have dry skin, on the other hand, you’ll want to choose a primer that is rich and creamy, as this will help to hydrate and nourish your skin. Other considerations include the ingredients list and the price.

Best Hydrating Primer at the Drugstore

Generally speaking, hyaluronic acid and sodium hyaluronate are both great ingredients for hydration, so look for these if possible. As for price, there is a wide range of options available, so just choose the one that fits your budget.

In sum, when choosing a hydrating primer, be sure to consider your skin type, the ingredients list, and the price. With these factors in mind, you’re sure to find the perfect primer for your needs.

What Are the Benefits of Using a Primer with Hyaluronic Acid or Sodium Hyaluronate? 

Hyaluronic acid is a substance that naturally occurs in the skin. It helps to keep the skin hydrated and plump by attracting and holding water molecules. However, as we age, our skin produces less hyaluronic acid, leading to dryness, wrinkles, and a loss of elasticity.

Luckily, hyaluronic acid or sodium hyaluronate can be applied topically in the form of a primer. When used before makeup, a primer with hyaluronic acid can help plump up the skin, reduce the appearance of fine lines and wrinkles, and create a smooth canvas for makeup application.

In addition, it can help keep the skin hydrated throughout the day by preventing water loss. As a result, using a primer with hyaluronic acid can help give you youthful-looking skin that is well-hydrated and primed for makeup.

How to Choose the Right Primer for Your Skin Type

If you’re like most people, you probably don’t give much thought to the type of primer you use before applying your makeup. However, choosing the right primer can make a big difference in the way your makeup looks. Here are a few tips to help you choose the right primer for your skin type:

  • If you have oily skin, look for a primer that contains silicone. Silicone will help to control excess oil and keep your makeup in place.
  • If you have dry skin, look for a primer that contains glycerin or aloe vera. These ingredients will help to hydrate your skin and prevent your makeup from looking cakey.
  • If you have sensitive skin, look for a hypoallergenic primer that is free from fragrances and dyes. This will help to reduce the risk of irritation and ensure that your makeup looks its best.

Choosing the right primer can be the key to achieving flawless-looking makeup. By taking the time to select a primer that is tailored to your specific skin type, you can enjoy long-lasting, beautiful results.

How to Apply the Primer for Best Results? 

Hydrating primer is an important step in any skincare routine, but it can be tricky to apply correctly. Here are a few tips to help you get the best results from your hydrating primer.

First, be sure to cleanse and tone your skin before applying the primer. This will help create a smooth, evenly textured surface for the primer to adhere to. Next, take a pea-sized amount of primer and warm it between your hands before applying it to your face. Be sure to avoid areas around the eyes, as the primer can cause irritation.

Once you have applied the primer, wait a few minutes for it to absorb into the skin before applying foundation or concealer. With these simple tips, you can ensure that your hydrating primer provides your skin with the moisture it needs to look its best.

The Importance of a Hydrating Primer

For many people, the word primer conjures up images of a spackling paste used to fill in small holes in walls before painting. However, in the world of cosmetics, a primer is a product that is applied before makeup in order to create a smooth, perfect canvas.

A good primer will not only help the foundation go on more smoothly, but it will also help it last longer and prevent unwanted shine. For those with dry skin, a hydrating primer can be an essential step in achieving a flawless complexion.

Hydrating primers are usually formulated with glycerin or hyaluronic acid, which help to attract and retain moisture. As a result, they can help to plump fine lines and give the skin a healthy, hydrated glow.

In addition, they create a barrier between the skin and makeup, preventing the foundation from settling into imperfections.

The Difference Between a Simple Primer and the One that Contains Hyaluronic Acid 

A simple primer is designed to help create a smooth canvas for foundation and other makeup. It typically contains silicone-based ingredients that fill in pores and fine lines, creating a smooth surface.

A primer that contains hyaluronic acid goes a step further by providing hydration. In addition to smoothing the skin, this type of primer helps to plump fine lines and wrinkles, giving the complexion a more youthful appearance. In addition, hyaluronic acid is an excellent choice for people with dry skin, as it helps to lock in moisture. Although both types of primers can help your makeup look its best, a hydrating primer may be a better choice if you have dry or mature skin.

In a Nutshell: 

If you’re on the hunt for a good drugstore primer that will help hydrate your skin, then you can’t go wrong with either a hyaluronic acid or sodium hyaluronate formulation. Both of these ingredients are very effective at attracting and retaining moisture, making them ideal for those with dry or dehydrated skin.

In addition, both hyaluronic acid and sodium hyaluronate are non-comedogenic, meaning they won’t clog your pores or cause breakouts. So if you’re looking for a hydrating primer that won’t break the bank, be sure to check out formulas containing one of these two key ingredients.

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