What Is Dihydromyricetin (DHM)

Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound known for its antioxidant properties. This compound is found predominantly in the Japanese raisin tree (Hovenia dulcis) and the Ampelopsis grossedentata plant.

These compounds help protect the body against oxidative stress and inflammation, which can lead to various chronic diseases. DHM, in particular, has gained attention for its unique properties and wide range of potential health benefits. It is commonly extracted from the Japanese raisin tree and is available in various forms.

Fig 1. Plant origin and chemical structure of dihydromyricetin

What Is Dihydromyricetin Used For

DHM is utilized for various purposes, because of its diverse therapeutic properties. Some of the primary uses include:

• Alcohol Hangover Relief: One of the most popular uses of DHM is to alleviate hangover symptoms.
• Anxiety Reduction: DHM has shown promise in reducing anxiety and promoting relaxation.
• Skin Health: Its antioxidant properties contribute to improved skin health and anti-aging effects.
• Hair Health: DHM may support hair growth and strength.
• Liver Protection: It offers hepatoprotective benefits, safeguarding the liver against damage.
• Headache Relief: DHM might help in reducing the frequency and severity of headaches.

Fig 2. The Benefits of Dihydromyricetin

–Dihydromyricetin for Hangovers

DHM has gained a lot of praise for its ability to lessen hangover symptoms. People think it works by speeding up how the liver breaks down alcohol and lowering alcohol’s effects on the brain. Research points to DHM changing the GABA receptors in the brain, which alcohol impacts. By getting these receptors back to normal, DHM can help ease symptoms like headaches feeling sick, being tired, and having a foggy mind that often comes with hangovers.

–Dihydromyricetin for Anxiety

Research indicates that DHM may have anxiolytic (anxiety-reducing) properties. It is thought to interact with the central nervous system in a way that promotes relaxation and reduces stress. The modulation of GABA receptors not only helps with hangovers but also plays a crucial role in anxiety management. By enhancing the calming effects of GABA, DHM can potentially reduce feelings of anxiety and improve overall mental well-being.

–Dihydromyricetin for Skin

DHM’s antioxidant qualities make it useful for skin health. Antioxidants fight free radicals, which can trigger oxidative stress and speed up aging and skin damage. By fighting these free radicals, DHM keeps skin elastic, cuts down on wrinkles, and helps maintain a young look. What’s more, it can calm irritated skin and lower the chances of acne and other skin issues because of its power to reduce inflammation.

–Dihydromyricetin for Hair

DHM also helps hair health. Its antioxidant traits shield hair roots from oxidative harm leading to healthier and stronger hair. Also, by boosting blood flow and cutting down on inflammation, DHM might help hair grow and stop hair loss. Using DHM supplements or putting it on your skin could result in thicker, shinier, and tougher hair.

–Dihydromyricetin for Liver

Dihydromyricetin offers a big plus: it guards the liver. Your liver cleans toxins from your body, and too much booze can hurt it. Studies show that DHM shields the liver from this harm. It does this by boosting enzymes that break down alcohol and cutting down on cell stress. This makes DHM a key helper for keeping your liver healthy especially if you drink alcohol.

Dihydromyricetin vs. Milk Thistle

People often compare milk thistle to DHM as a supplement for liver health. Both help protect the liver, but they work. Milk thistle has silymarin, which shields liver cells from toxins and helps the liver grow back. DHM speeds up how the body breaks down alcohol and cuts down on oxidative stress. While both supplements boost liver health, DHM might work better for quick hangover relief. Milk thistle, however, might offer wider liver protection over time.

Read more: Introduction to Milk Thistle: A Fatty Liver Savior

–Dihydromyricetin for Headache

Besides easing hangovers, DHM might also help reduce headaches. It affects GABA receptors and lowers inflammation, which can ease the pain and discomfort of headaches. Its support for liver function also plays a part. A healthy liver can clean toxins from the body more and cut down on things that trigger headaches.

Is Dihydromyricetin Safe

DHM has a reputation for safety among most users when consumed in proper amounts. Still, like any supplement, it might cause side effects. Some people could feel a bit sick to their stomach maybe feeling queasy or having loose stools. It’s crucial to check with your doctor before you start taking DHM if you have health issues or you’re on other meds. Pregnant and breastfeeding women should also seek medical advice before using DHM.

Dihydromyricetin: How Long to Work

The onset of DHM’s effects can vary depending on the individual and the context in which it is used. For hangover relief, many users report feeling better within 30 minutes to an hour after taking DHM. For anxiety reduction, it may take a few days of regular use to notice significant improvements. When used for skin and hair health, the benefits may become apparent over several weeks of consistent use. The protective effects on the liver can also be seen over time with regular supplementation.

Stanford Chemical Company (SCC) is an excellent supplier of herb extracts. We provide Dihydromyricetin (DHM), Swertiamarin, Shikimic Acid, and other extracts. For more information on these materials, please check our home page.

Conclusion

Dihydromyricetin is a versatile and beneficial supplement with a wide range of health applications. From alleviating hangovers and reducing anxiety to promoting skin and hair health and protecting the liver, DHM offers numerous advantages. While generally safe, it is essential to use DHM responsibly and consult with a healthcare provider before starting any new supplement regimen. As research continues, the full potential of DHM will likely become even more evident, solidifying its place in the world of natural health and wellness.

The post The Power of Dihydromyricetin: Uses, Benefits, and Safety appeared first on Stanford Chemicals.

Fig 1. Top 5 Benefits of DHM

1. DHM: The Antioxidant for Health and Wellness

Dihydromyricetin has excellent antioxidant activity, which offers several benefits.

Benefits of DHM in Antioxidant

DHM can scavenge free radicals. We know that excessive free radicals can cause cell damage and oxidative stress. Dihydromyricetin can react with free radicals and neutralize them.

Moreover, DHM can inhibit lipid peroxidation. Because the formation of lipid peroxides is prevented, the integrity of the cell membrane is protected.

In addition, Dihydromyricetin can upregulate the activity of antioxidant enzymes in the body. And then it can enhance the body’s antioxidant defense ability.

Applications Based on Antioxidant Properties:

This antioxidant effect shows great potential in various applications.

• Antioxidant Supplements: DHM is widely used in antioxidant supplements to help consumers neutralize excess free radicals, protect cells, slow aging, and prevent chronic diseases.
• Food Additives: DHM’s antioxidant properties make it an ideal natural food preservative, preventing lipid oxidation in foods, extending shelf life, and maintaining freshness and nutritional value.
• Anti-aging Skincare: Dihydromyricetin is commonly used in anti-aging skincare products. It can neutralize free radicals in the skin and prevent oxidative damage. Apart from that, DHM can reduce wrinkles and fine lines, and maintain skin elasticity and radiance.
• Sunscreen Products: DHM’s antioxidant effect helps counteract oxidative stress caused by UV radiation. It then protects the skin by reducing sun damage and photoaging.

Read more: Can Dihydromyricetin Be Used in Skincare Products

2. DHM: The Natural Solution for Inflammation Relief

Extensive basic research and animal experiments have evidenced the anti-inflammatory effects of DHM. Clinical studies also provide compelling evidence of DHM’s anti-inflammatory efficacy in humans.

Benefits of DHM in Anti-inflammatory

Experimental evidence suggests that dihydromyricetin exerts its anti-inflammatory effects mainly through:

• Inhibition of Inflammatory Mediator Production: DHM reduces the production of cytokines and other inflammatory mediators.
• Regulation of Inflammatory Signaling Pathways: Dihydromyricetin modulates pathways such as NF-κB, which are crucial for the inflammatory response.
• Inhibition of Inflammatory Cell Migration and Activation: DHM prevents the movement and activation of cells involved in inflammation.

Fig 2. Anti-inflammatory effects of dihydromyricetin

Applications in Anti-inflammatory Treatments:

The above studies will provide a more solid scientific basis for the application of DHM in anti-inflammatory treatment.

• Anti-inflammatory Drugs: Dihydromyricetin is a promising candidate for developing drugs to treat various acute and chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
• Anti-inflammatory Health Supplements: Dihydromyricetin is used in health supplements to help consumers reduce chronic inflammation and prevent chronic diseases.
• Anti-inflammatory Skincare: DHM is used in skincare products to alleviate skin inflammation, such as acne and eczema, promoting skin health.
• Soothing Repair Products: The anti-inflammatory and antioxidant properties of Dihydromyricetin make it an ideal component in products designed to repair damaged skin and reduce inflammation.

More information: Dihydromyricetin (DHM) for Inflammatory Diseases and Anxiety Disorders

3. DHM: Nature’s Weapon Against Cancer

Multiple studies have shown that Dihydromyricetin can effectively inhibit the proliferation of various cancer cells in vitro, including liver cancer, breast cancer, gastric cancer, and lung cancer. In animal models, Dihydromyricetin has been proven to significantly suppress tumor growth. For instance, a study demonstrated that DHM significantly reduced tumor volume and weight in a mouse model of breast cancer while lowering tumor angiogenesis.[i]

Benefits of DHM in Anticancer:

• Inhibition of Cancer Cell Proliferation: DHM blocks the cell cycle, preventing cancer cells from dividing and growing.
• Induction of Cancer Cell Apoptosis: Dihydromyricetin triggers apoptosis, or programmed cell death, in cancer cells.
• Inhibition of Tumor Angiogenesis: DHM prevents the formation of new blood vessels that supply nutrients to tumors.
• Inhibition of Cancer Cell Invasion and Metastasis: DHM reduces the ability of cancer cells to invade surrounding tissues and spread to other parts of the body.

Applications in Cancer Treatment:

Although existing clinical research is still in its early stages, Dihydromyricetin, as a natural, low-toxic anticancer compound, has broad application prospects.

• Cancer Drug Development: DHM’s multiple anticancer mechanisms make it a potential candidate for developing anticancer drugs. It can be used alone or in combination with other chemotherapeutic agents to enhance efficacy and reduce side effects.
• Adjunctive Therapy: Dihydromyricetin can be used as an adjunctive treatment for cancer patients. It helps to mitigate the side effects of chemotherapy and radiation therapy.

4. DHM: Nature’s Defense for Liver Health

Dihydromyricetin is recognized for its potent antioxidant, anti-inflammatory, and antifibrotic properties, making it an effective liver-protective agent.

Benefits of DHM in Liver Protection:

Dihydromyricetin has a strong antioxidant effect and can reduce the damage of oxidative stress to liver cells. In addition, DHM can inhibit the production of inflammatory mediators, reduce inflammatory response, and thus protect the liver.

Additionally, dihydromyricetin can inhibit the progression of liver fibrosis. It reduces the degree of liver fibrosis by reducing the deposition of collagen and the activation of hepatic stellate cells.

DHM also can promote the regeneration and repair of liver cells and enhance the self-repair ability of the liver.

Applications in Liver Health:

DHM’s liver-protecting effect makes it widely used in health products and medicines.

• Liver Health Supplements: DHM is widely used in liver health supplements to improve liver function and prevent or mitigate alcohol-induced liver damage.
• Hangover Remedies: DHM is a key ingredient in hangover remedies. It aids in the acceleration of alcohol consumption and reduces hangover symptoms. Ultimately, it protects the liver from alcohol damage. Maybe you are interested: Does DHM (Dihydromyricetin) Actually Reduce Hangovers?
• Anti-fibrotic drugs: Dihydromyricetin has anti-fibrotic properties. Therefore, It is a potential candidate for drugs to treat various fibrotic liver diseases.
• Hepatitis treatment: Dihydromyricetin is expected to reduce liver damage caused by viral hepatitis. So, it is used to develop drugs for hepatitis treatment.
• Functional foods: Dihydromyricetin is added to functional foods to enhance their health benefits.

5. DHM: A Natural Solution for Cardiovascular Health

Dihydromyricetin exhibits significant antithrombotic and lipid-lowering effects, which contribute to cardiovascular protection.

Benefits of DHM in Cardiovascular Protection

It can inhibit platelet aggregation and reduce the risk of thrombosis. In addition, DHM maintains the normal function of blood vessels by enhancing endothelial function, promoting vasodilation, and inhibiting vasoconstriction.

Applications in Cardiovascular Health:

DHM’s effects on the cardiovascular system have been applied in the healthcare and medical industries.

• Cardiovascular Health Supplements: DHM is used in supplements to help consumers prevent cardiovascular diseases and improve cardiovascular function. Its antioxidant and anti-inflammatory properties make it an ideal cardiovascular protective agent.
• Anti-Atherosclerotic Drugs: DHM’s anti-inflammatory and antioxidant actions make it a potential candidate for developing drugs to prevent and treat atherosclerosis.
• Lipid-Lowering Drugs: DHM’s ability to regulate lipid levels suggests it could be used in developing drugs to lower cholesterol and reduce the risk of cardiovascular diseases.

Additional Benefits of Dihydromyricetin

Dihydromyricetin is a versatile natural compound with a wide range of health benefits. In addition to the five benefits listed above, dihydromyricetin has other benefits.

1. Neuroprotective Effects

Dihydromyricetin has shown promising neuroprotective effects. DHM may help in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies suggest that DHM improves cognitive performance and memory by reducing oxidative stress and inflammation in the brain​.

2. Metabolic Health

DHM has been found to have beneficial effects on metabolic health.

• Improving Insulin Sensitivity: DHM enhances insulin sensitivity, which can help in managing blood sugar levels and reducing the risk of type 2 diabetes​.
• Reducing Fat Accumulation: DHM can inhibit the differentiation of preadipocytes into adipocytes, thus reducing fat accumulation and helping in weight management​.
• Lowering Blood Glucose Levels: DHM has been shown to lower fasting blood glucose levels in animal studies, indicating potential benefits for diabetic patients​.

Fig 3. blood glucose

3. Anti-aging Properties

Beyond its antioxidant effects, dihydromyricetin contributes to overall anti-aging. It’s because DHM may extend the lifespan of cells by protecting them from oxidative stress.​

4. Skin Health

DHM can reduce Hyperpigmentation and promote collagen production. In addition, dihydromyricetin’s antioxidant properties protect the skin from damage caused by UV radiation.

5. Immune System Support

DHM can modulate the immune system by enhancing immune response and regulating inflammatory responses.

Stanford Chemical Company (SCC) is a premium supplier of hyaluronic acid and herbal extracts. We offer Dihydromyricetin and Medical-grade Pure HA Powder. For more information on these products or specific applications, please contact us and check out our home pages.

Conclusion

The multiple health benefits of Dihydromyricetin make it a valuable compound for various applications in health and medicine. Its powerful antioxidant, anti-inflammatory, anticancer, liver-protective, and cardiovascular-protective properties provide a strong foundation for developing new health supplements, functional foods, and pharmaceuticals. As research continues, DHM’s full potential in promoting health and preventing disease will likely be further realized, offering new avenues for enhancing human well-being.

[i] Chen, L., Yang, Z.S., Zhou, Y.Z., Deng, Y., Jiang, P., Tan, S.L. (2020). Dihydromyricetin inhibits cell proliferation, migration, and invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells. Journal of Cancer, 11(19), 5689-5699. https://doi.org/10.7150/jca.45970.

The post Top 5 Powerful Benefits of Dihydromyricetin in Health appeared first on Stanford Chemicals.

Is DHM good for the liver?

DHM could potentially help patients who go to the doctor with early warning signs of liver damage. The substance could be used to help restore and prolong liver function and delay the onset of liver disease while waiting for a transplant.

What is Dihydromyricetin good for?

Biologically, recent studies have demonstrated that dihydromyricetin shows multiple health-benefiting activities, including antioxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose-metabolism-regulatory activities.

The post Miraculous Herbal Ingredient Caring Your Liver – Dihydromyricetin appeared first on Stanford Chemicals.