(R)-(-)-Glycidyl Nosylate – Stanford Chemicals https://www.stanfordchem.com Global Supplier of Hyaluronic Acid & Chondroitin Sulfate Tue, 12 Aug 2025 09:02:09 +0000 en-US hourly 1 https://wordpress.org/?v=4.9.18 https://www.stanfordchem.com/wp-content/uploads/2018/08/cropped-STANFORD-CHEMICALS-LOGO-1-32x32.jpg (R)-(-)-Glycidyl Nosylate – Stanford Chemicals https://www.stanfordchem.com 32 32 040-000-474 (R)-(-)-Glycidyl Nosylate https://www.stanfordchem.com/r-glycidyl-nosylate.html Thu, 13 Jan 2022 09:16:51 +0000 https://www.stanfordchem.com/?post_type=product&p=8481 Type Active Pharmaceutical Ingredient CAS No. 115314-17-5 Chemical Formula C9H9NO6S Appearance white crystalline powder Density 1.527 g/cm3 Assay ≥98% Related Products Silodosin, Ibuprofen Alcohol, 3,5-Difluoro-4-iodoaniline

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]]> (R)-(-)-Glycidyl Nosylate Introduction

(R)-(-)-Glycidyl Nosylate is a carboxylic acid ester derivative and can be used as a pharmaceutical intermediate.

(R)-(-)-Glycidyl Nosylate Specification

Melting Point 59-63℃
Boiling Point 432.2±20.0℃
Chemical Formula C9H9NO6S
Appearance white crystalline powder
Density 1.527 g/cm3
Storage conditions Inert atmosphere, 2-8°C

(R)-(-)-Glycidyl Nosylate Applications

  1. Chiral Building Block:

    • Used to introduce the (R)-glycidyl moiety into target molecules, enabling asymmetric synthesis of:

      • β-Blockers (e.g., (R)-propranolol).

      • Antiviral agents and protease inhibitors.

      • Other optically active pharmaceuticals.

  2. Epoxide Reactivity:

    • The strained epoxide ring undergoes nucleophilic ring-opening reactions with amines, alcohols, or thiols, facilitating C–N, C–O, or C–S bond formation with retained stereochemistry.

  3. Nosylate Group Utility:

    • Acts as a leaving group in substitution reactions, enhancing reactivity in SN₂-type transformations.

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