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040-000-474 (R)-(-)-Glycidyl Nosylate

(R)-(-)-Glycidyl Nosylate
SKU: 040-000-474 Category: Tag:
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Type Active Pharmaceutical Ingredient
CAS No. 115314-17-5
Chemical Formula C9H9NO6S
Appearance white crystalline powder
Density 1.527 g/cm3
Assay ≥98%
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Description

Description

(R)-(-)-Glycidyl Nosylate Introduction

(R)-(-)-Glycidyl Nosylate is a carboxylic acid ester derivative and can be used as a pharmaceutical intermediate.

(R)-(-)-Glycidyl Nosylate Specification

Melting Point 59-63℃
Boiling Point 432.2±20.0℃
Chemical Formula C9H9NO6S
Appearance white crystalline powder
Density 1.527 g/cm3
Storage conditions Inert atmosphere, 2-8°C

(R)-(-)-Glycidyl Nosylate Applications

  1. Chiral Building Block:

    • Used to introduce the (R)-glycidyl moiety into target molecules, enabling asymmetric synthesis of:

      • β-Blockers (e.g., (R)-propranolol).

      • Antiviral agents and protease inhibitors.

      • Other optically active pharmaceuticals.

  2. Epoxide Reactivity:

    • The strained epoxide ring undergoes nucleophilic ring-opening reactions with amines, alcohols, or thiols, facilitating C–N, C–O, or C–S bond formation with retained stereochemistry.

  3. Nosylate Group Utility:

    • Acts as a leaving group in substitution reactions, enhancing reactivity in SN₂-type transformations.

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