(R)-(-)-Glycidyl Nosylate Introduction

(R)-(-)-Glycidyl Nosylate Specification

(R)-(-)-Glycidyl Nosylate Applications

1. Chiral Building Block:

   • Used to introduce the (R)-glycidyl moiety into target molecules, enabling asymmetric synthesis of:

     • β-Blockers (e.g., (R)-propranolol).

     • Antiviral agents and protease inhibitors.

     • Other optically active pharmaceuticals.

2. Epoxide Reactivity:

   • The strained epoxide ring undergoes nucleophilic ring-opening reactions with amines, alcohols, or thiols, facilitating C–N, C–O, or C–S bond formation with retained stereochemistry.

3. Nosylate Group Utility:

   • Acts as a leaving group in substitution reactions, enhancing reactivity in SN₂-type transformations.