040-000-293 Oseltamivir Acid, CAS 187227-45-8

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Synonym 4R-(acetylamino)-5S-amino-3R-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid
Type Neuaminidase inhibitor
Keywords Neuaminidase, influenza
Related products Arbidol Hydrochloride, Sirolimus
Description

Description

Oseltamivir Acid Specifications

Product Name Oseltamivir Acid
CAS Registry Number 187227-45-8
Molecular Formula C14H24N2O4
Molecular Weight 284.4 g/mol
Purity 98 %
Appearance White crystalline powder
Package 1kg-25kg
Shelf life 2 years
Functions inhibitor of neuraminidase, treating influenza

Oseltamivir Acid Description

Oseltamivir is a specific inhibitor of neuraminidase. Its inhibitory effect on neuraminidase can inhibit the mature influenza virus from detaching from host cells, thereby inhibiting the spread of influenza virus in the human body to play a role in treating influenza. Oseltamivir acid is the active metabolite of oseltamivir.

oseltamivir acid

oseltamivir acid

Oseltamivir Acid Applications

  • Pharmaceutical of anti-flu drugs
  • Laboratory research

Reference:

  1. Govorkova, E.A., Ilyushina, N.A., McClaren, J.L., et al. Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model. Antimicrobial Agents and Chemotherapy 53(7), 3088-3096 (2009).
  2. Krueger, A.C., Xu, Y., Kati, W.M., et al. Synthesis of potent pyrrolidine influenza neuraminidase inhibitors. Bioorganic & Medicinal Chemistry Letters 18(5), 1692-1695 (2008).
  3. Lew, W., Wu, H., Chen, X., et al. Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: Synthesis and inhibitory activity. Bioorganic & Medicinal Chemistry Letters 10(11), 1257-1260 (2000).