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040-000-292 Arbidol Hydrochloride, CAS 131707-23-8

arbidol hydrochloride
SKU: 040-000-292 Category:
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Synonyms 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid
Type Antibiotics, protease, tyrosine kinase inhibitor
Keywords Anti-vierus, COVID-19, antiviral, SARS-CoV-2, anti-infection, anti-influenza
Related products Piperaquine, Chloroquine Diphosphate, Artemisinin, Acrichin Dihydrochloride
Description

Description

Arbidol Hydrochloride Specifications

Product Name Arbidol Hydrochloride
CAS Registry Number 131707-23-8
Molecular Formula C22H25BrN2O3S•HCl
Molecular Weight 513.9 g/mol
Purity 99.5 %
Appearance White powder
Package 1kg-25kg
Shelf life 2 years
Functions Anti-infection, anti-influenza, anti-vierus

Arbidol Hydrochloride Description

Arbidol is a broad-spectrum, indole-based antiviral compound that blocks viral fusion with target membranes, prohibiting viral entry into cells. Because arbidol targets a common critical step for viral replication, it is effective against numerous viruses, including influenza A, B, and C and hepatitis B and C (IC50s range from 3-12.5 µg/ml). Besides its antiviral action, arbidol has been reported to produce an immunomodulatory response by inducing interferon production and stimulating the phagocytic function of macrophages.

Arbidol hydrochloride is a non-nucleoside antiviral drug. Arbidol can specifically inhibit the contact, adhesion, and fusion of virus lipid envelope with the host cell membrane by activating the antiviral protein in the host, thereby inhibiting the replication of the virus in host cells.

arbidol hydrochloride

arbidol hydrochloride

Arbidol Hydrochloride Applications

  • Anti-influenza drugs against influenza A and B viruses
  • Laboratory research

Reference:

  1. Kramarev SA, Moshchich AP.[The treatment of influenza and acute respiratory viral infections]. Lik Sprava. 2013 Mar;(2):99-106.
  2. Kadam RU, Wilson IA. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol.Proc Natl Acad Sci U S A 2017 Jan 10;114(2):206-214.
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