Medical Grade Sodium Hyaluronate

01 Overview

Stanford Chemicals provide high quality and pure sodium hyaluronate as the pharmaceutical ingredient in the wide range of molecular weights, together with innovative and affordable derivatives and other hyaluronan specialties.

02 Product Description

1.Medical Grade Sodium Hyaluronate

Product and Specifications:

Item No. Specification Inquiry
HA-EPM1 0.2-4.0 m3/kg; 10K-3,000K Da

COA HA-EPM1

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HA-EPM1.0/2.0 Updated medical grade

PDFCOA HA-EPM1.0

PDFCOA HA-EPM2.0

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HA-EM2.0 (DMF) 1.3-1.5 m3/kg; 800K-1,300K Da

PDFCOA HA-EM2.0

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HA-EM3.0 (DMF) 2.7-3.6 m3/kg; 1,600K-2,500K Da

PDFCOA HA-EM3.0

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HA-PM-0.5 (DMF) 0.5-1.0 m3/kg; 20K-60K Da

PDFCOA HA-PM-0.5

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Items

Specifications

Appearance White powder
Infrared absorption spectrophotometry Ph. Eur. Reference Standards
Appearance of solution A600nm≤0.01
pH (5mg/mL solution) 5.0-8.0
Intrinsic viscosity Measured values
Molecular weight Measured values
Sulfated glycosaminoglycans ≤1%
Nucleic acid A260nm≤0.5
Protein ≤0.1%
Chlorides ≤0.5%
Iron ≤80ppm
Heavy metals ≤20ppm
Loss on drying ≤20.0%
Bacterial counts ≤100cfu/g
Mold and Yeast ≤100cfu/g
Sodium hyaluronate 95%-105%
Glucuronic acid ≥42.0%

Functions:

  • Viscoelasticity, protecting corneal endothelium;
  • Lubricating, viscoelasticity, repairing damage cartilage, inhibition of inflammation, pain relief, etc.;
  • Properties of good biocompatibility and degradability of HA and its derivatives.

Applications:

For parenteral preparations or oral preparations not including intra-articular and intra-ocular preparations. It can be used in eye drops, contact lens solutions, topical preparations for the wound or burn healing, medical lubricants, etc.
1 Medical Devices:
• ophthalmic surgery (viscosupplementation)
• eye drops for dry eye (eg. artificial tears)
• intra-articular injections
• topical preparations for wound and burns healing
• intradermal injections for aesthetic correction
• anti-adhesive and shape keeping products for thoracic
and abdominal surgery
• anti-adhesive wound healing products
• bandages with exudates absorbing capacity
2. Remedies /Drugs:
Sodium hyaluronate on its own as active substance
• cartilage (joint) and tendon disorders
• wound and burns healing preparations
Sodium hyaluronate in combination with other active
substances
• anti-cancer preparations
• wound and burns healing preparations
• preparations for reduction of scar formation
• eye drops
• topical anti-inflammatory and analgesics preparations
• cartilage (joint) and tendon disorders
• nutraceuticals supporting the treatment
of skeleton or prevention of skeleton disorders
• preparations for liver regeneration
3.Issue Engineering:
• artificial skin grafts for plastic and reconstruction surgery
• artificial skin for the test of cosmetic raw material
• replacement of injured cartilage, artificial cartilage grafts
• artificial bone grafts
• adipose tissue replacement
• support for the growth of soft tissue grafts
• aorta and large venous grafts industry
4. Application in Biotechnology and Molecular Biology:
• component of special cell culture medium
• supporting material for gene transfer
• biotinylated for detection of hyaluronan binding proteins
5. Other Biological Applications:
• sperm separation according to their mobility
• medium for in vitro ovum fertilizationFor parenteral preparations or oral preparations not including intra-articular and intra-ocular preparations. It can be used in eye drops, contact lens solutions, topical preparations for the wound or burn healing, medical lubricants, etc.

2.Injection Grade Hyaluronic Acid

Product and Specifications:

Item No. Specification Inquiry
HA-EP1.8 (DMF/CEP/KDMF) 1.6-2.2 m3/kg; 800K-1,300K Da

PDFCOA HA-EP1.8

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HA-EP3.0 (DMF/CEP/KDMF) 2.7-3.6 m3/kg; 1,600K-2,500K Da

PDFCOA HA-EP3.0

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HA-EP2

(DMF open part)

0.2-4.0 m3/kg; 10K-3,000K Da

PDFCOA HA-EP2

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Functions:
  • Viscoelasticity, protecting corneal endothelium;
  • Lubricating, viscoelasticity, repairing damage cartilage, inhibition of inflammation, pain relief, etc.;
  • Properties of good biocompatibility and degradability of HA and its derivatives.

Applications:

For parenteral preparations including intra-articular and intra-ocular preparations, such as OVD, intra-articular injections, intradermal injections for aesthetic correction, anti-adhesive products, etc.

3.Cosmetic Grade Hyaluronic Acid

Product and Specifications:

Item No. Specification Inquiry
HAC-H-SC >1,800K Da

PDFCOA

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HAC-M-SC 800K-1,600K Da

PDFCOA HAC-M-SC

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HAC-N-SC 200K-600K Da

PDFCOA HAC-N-SC

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HAC-L-SC 10K-1,000K Da

PDFCOA HAC-L-SC

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HAC-Oligo-SC <10K Da

PDFCOA HAC-L-SC

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HAC-H >1,800K Da

PDFCOA HAC-H

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HAC-M 1,000K-1,800K Da

PDFCOA HAC-M

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HAC-L 10K-1,000K Da

PDFCOA HAC-L

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HAC-N 200K-400K Da

PDFCOA HAC-N

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HAC-mini <10K Da

PDFCOA HAC-mini

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Functions:

  • Lubricating and film-forming, moisturizing, preventing skin damage, thickening and keeping emulsion stable;
  • Nourishing the skin, long-lasting moisturizing;
  • Trans-dermal absorption, deep hydrating, anti-ageing, repairing skin damage.

Applications:

Skin care products: cream, emulsion, essence, lotion, gel, facial mask, etc.;
Beauty products: lipstick, eyeshadow, foundation, etc.;
Cleansing products: facial cleanser, body wash, etc.;
Hair products: shampoo, hair conditioner, styling gel, hair restorer, etc.

4.Food Grade Hyaluronic Acid

Product and Specifications:
Item No. Specification Inquiry
HAF-H-SC >1,800K Da

PDFCOA HAF-H-SC

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HAF-M-SC 800K-1,600K Da

PDFCOA HAF-M-SC

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HAF-N-SC 200K-600K Da

PDFCOA HAF-N-SC

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HAF-L-SC 10K-1,000K Da

PDFCOA HAF-L-SC

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HAF-Oligo <10K Da

PDFCOA HAF-Oligo

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HA-F 200K-600K Da

PDFCOA HA-F

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HA-C Customized molecular weight

PDFCOA HA-C

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Functions:
  • Restore skin moisture, improve skin health condition;
  • Antioxidation;
  • Improve joint health;
  • Improve bowel function and protect gastric mucosa.

Applications:

Common food: beverage, jelly, dairy products, etc.;
Health food: usually in combination with Collagen,  Vitamins, Chondroitin Sulphate, or Glucosamine to make tablets, capsules or oral liquid these popular form.

03 Questions & Answers

  1. 1
    What is Hyaluronic Acid ?

    Hyaluronan (also called hyaluronic acid or hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Hyaluronan is a polymer of disaccharides, themselves composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. It can be obtained by extracting from cockscomb or through microorganism fermentation.

  2. 2
    Where is Sodium Hyaluronate Found?

    Sodium hyaluronate exists in many parts of human body such as skin, joint, eye, or umbilical cord having various functions in different body parts.
    For example, sodium hyaluronate in skin prevents skin from drying and works to give skin resilience and elasticity. Sodium hyaluronate in joint gives cushion helping joint’s smooth movement. Sodium hyaluronate is characterized by high water retention and viscoelasticity, widely being used in pharmaceutical products, quasi-drugs, cosmetics, and food.

  3. 3
    Why is Hyaluronic Acid Important?

    Hyaluronic acid plays an important role in the human biologic activity. With the increase in age, the content of hyaluronic acid in the body will decrease. The decrease of hyaluronic acid content in the human body will weaken the water retaining ability of the skin, make the skin look coarse and wrinkle; lead to arthritis, arteriosclerosis, plus disorder and brain atrophy, and finally premature senility.

  4. 4
    What is Medical Benefits of Hyaluronic Acid

    According to the Supplement Research Foundation, “HA seems to work through several mechanisms of action including restoration of more normal synovial fluid with improved viscoelasticity, effects on cartilage biosynthesis and degradation, anti-inflammatory effects, and direct analgesic effects.” Hyaluronic acid supplements are also considered to be an effective treatment for conditions such as arthritis, chronic fatigue syndrome, fibromyalgia, and pain linked to joint damage. Additionally, the supplements can be useful in increasing bone density, muscle strength, mobility, alertness, sleep quality, sexual potency and wound healing.

04 Product Videos

How does Sodium Hyaluronate Work?

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For the past 16 years, Stanford Chemicals has focused its efforts on R&D, production, and sales of Medical Sodium Hyaluronate (HA). Stanford Chemicals’ HA is used in various products, such as osteoarthritis visco-supplements, ophthalmic viscoelastic adjuvant, aesthetic surgery adjuvant, eye drops, and adhesion barrier.

Why Stanford Chemicals?

1. Original fermentation technology
Stanford Chemicals’ original manufacture method results in high purity. Our sodium hyaluronate not only complies with public standard but also meets the more strict specification of our own.
2. Non-animal origin guaranteed
Stanford Chemicals is committed to ensuring non-animal origin for all raw materials in the manufacture of sodium hyaluronate.
3. Certifications and Compliance
Stanford Chemicals is managed strictly in accordance with GMP and ISO 9001 quality management system to ensure the reliability and stability of products, and obtained licenses for the manufacture of HA by fermentation for Pharmaceutical API & Excipient grades HA.