020-000-275 Methacrylated Hyaluronic Acid (HAMA)

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Specifications of Methacrylated Hyaluronic Acid (HAMA)

Product Name Methacrylated Hyaluronic Acid (HAMA)
Molecular Weight 100-150 kDa
Degree of Methacrylation 45-65 %
Appearance Lyophilized powder
Storage -20°C
Shelf life Minimum of 6 months from date of receipt
Heavy metals ≤ 20 ppm
Loss on drying ≤ 10%
Description

Description

Introduction of Methacrylated Hyaluronic Acid (HAMA)

Hyaluronic acid is the most abundant glycosaminoglycan in the body being an important component of several tissues throughout the body. While it is abundant in extracellular matrices, hyaluronan also contributes to tissue hydrodynamics, movement, and proliferation of cells, and participates in a number of cell surface receptor interactions.

Methacrylated hyaluronic acid (HAMA) is for photocrosslinkable hydrogels. These hydrogels provide native-like 3D HA gels with the unique attributes to be prepared at various concentrations and photocrosslinked to provide various gel stiffness.

HAMA HAMA


Applications of
Methacrylated Hyaluronic Acid (HAMA):

  • Used to form hydrogels for ex-vivo engineering of the autologous cartilage tissue or as a mesenchymal stem cell carrier in cartilage repair
  • Used to measure the effects of matrix stiffness on cell phenotype and function
  • Used for 3D bioprinting to create structures that promote osteogenic differentiation of MSC’s
  • The high tunability of hyaluronic acid methacrylate allows it to be mixed with, and reinforce other types of hydrogels (such as collagen, or gelatin methacrylate)

Reference:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717235/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627486/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541838/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447944/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615317/
  6. https://www.ncbi.nlm.nih.gov/pubmed/21773726/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460858/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748291/