040-000-295 Peramivir, CAS 330600-85-6

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Synonyms (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid
Type Neuraminidase
Keywords Influenza, anti-virus
Related products Piperaquine, Chloroquine Diphosphate, Artemisinin, Acrichin Dihydrochloride
Description

Description

Peramivir Specifications

Product Name C15H28N4O4
CAS Registry Number 330600-85-6
Molecular Formula C15H28N4O4
Molecular Weight 324.8 g/mol
Purity 99 %
Appearance White crystalline solid
Package 1kg-25kg
Shelf life 2years
Functions Treating Influenza A and B

Peramivir Description

Peramivir is an antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases. Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection. Formulations containing peramivir have been used to treat influenza.

peramivir

peramivir

Peramivir Applications

  • Pharmaceutical of anti-flu drugs

Reference:

  1. Young, D., Fowler, C., and Bush, K. RWJ-270201 (BCX-1812): A novel neuraminidase inhibitor for influenza. Philos. Trans. R. Soc. Lond. B Biol. Sci 356(1416), 1905-1913 (2001).
  2. Yun, N.E., Linde, N.S., Zacks, M.A., et al. Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1). Virology 374(1), 198-209 (2008).