Losartan Potassium Specifications

Product Name	Losartan Potassium
CAS Registry Number	124750-99-8
Molecular Formula	C22H22ClKN6O
Molecular Weight	461 g/mol
Purity	>99 %
Package	1kg-25kg
Solubility	DMSO : ≥ 110 mg/mL (238.61 mM) H2O : 33.33 mg/mL (72.30 mM; Need ultrasonic)
Shelf life	2 years
Functions	Treatment of high blood pressure, diabetic kidney disease, heart failure, etc.

Losartan Potassium Description

Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone.

Losartan potassium is a prescription drug used to treat hypertension (high blood pressure).

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How Losartan Potassium Works?

Losartan Potassium relaxes blood vessels by blocking angiotensin II. Angiotensin II is a vasoconstrictor that narrows blood vessels, causing blood pressure to rise.
Losartan Potassium reduces the secretion of aldosterone. Aldosterone is a hormone that causes the kidneys to retain sodium and water, causing an increase in blood volume and blood pressure. Angiotensin II stimulates the release of aldosterone. By blocking angiotensin II, Losartan Potassium reduces aldosterone secretion, which helps further lower blood pressure.

Losartan Potassium Applications

Losartan is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.

Common Side Effects of Losartan Potassium

• upper respiratory infections
• dizziness
• back pain
• diarrhea
• stuffy nose
• fatigue
• low blood sugar
• chest pain
• high or low blood pressure

Reference:

1. Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344
2. Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531
3. Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862