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- 040-000-285 Losartan Potassium, CAS 124750-99-8
040-000-285 Losartan Potassium, CAS 124750-99-8
Synonyms | 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt |
Key words | COVID-19, blood pressure, diabetic kidney disease, heart failure |
Related products | Hydroxychloroquine sulfate, Remdesivir |
- Description
Description
Losartan Potassium Specifications
Product Name | Losartan Potassium |
CAS Registry Number | 124750-99-8 |
Molecular Formula | C22H22ClKN6O |
Molecular Weight | 461 g/mol |
Purity | >99 % |
Package | 1kg-25kg |
Solubility | DMSO : ≥ 110 mg/mL (238.61 mM)
H2O : 33.33 mg/mL (72.30 mM; Need ultrasonic) |
Shelf life | 2 years |
Functions | Treatment of high blood pressure, diabetic kidney disease, heart failure, etc. |
Losartan Potassium Description
Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone.
Losartan potassium is a prescription drug used to treat hypertension (high blood pressure).
losartan potassium
Losartan Potassium Applications
Losartan is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
Reference:
- Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344
- Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531
- Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862