Didesethyl Chloroquine Specifications

Didesethyl Chloroquine Description

Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.

Didesethyl Chloroquine Applications

• Used in COVID19-related research

Reference:

1. Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981)
2. Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992)
3. Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003)
4. Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004)