|Synonyms||DTX, DXL, Taxotere|
|Keywords||Antibiotics, non-small-cell lung cancer, taxol, paclitaxel, cancer|
|Related products||Paclitaxel (Taxol), Taxus Chinensis Extract|
|CAS Registry Number||114977-28-5|
|Molecular Weight||807.55 g/mol|
|Shelf life||2 years|
|Functions||It can treat breast, lung, prostate, stomach, and head and neck cancer.|
Docetaxel (docetaxel) has the same effect as paclitaxel (PTX). It is a M-cycle specific drug that promotes the polymerization of tubules into stable microtubules and inhibits their aggregation, thereby significantly reducing the number of tubules. And can destroy the microtube network structure. In vitro experiments show that it has a cytotoxic effect on a variety of mouse and human tumor cell lines, with a broader anti-tumor spectrum than PTX.
- Pharmaceutical ingredients of anti-cancer drugs.
- Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al. Pathways of chemotherapy resistance in castration-resistant prostate cancer. Endocrine-Related Cancer 18, R103-R123 (2011).
- Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Research 51, 4845-4852 (1991).
- Yao, X., Hosenpud, J., Chitambar, C.R., et al. A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancer. Journal of Cancer 3, 145-151 (2012).