Acrichin Dihydrochloride Specifications

Product Name	Acrichin Dihydrochloride
CAS Registry Number	69-44-3
Molecular Formula	C20H22ClN3O.2(HCl)
Molecular Weight	428.78 g/mol
Purity	>99.0 %
Appearance	White powder
Package	1kg-25kg
Shelf life	2 years
Functions	highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax

Acrichin Dihydrochloride Description

Amodiaquine hydrochloride tablets are used to treat acute febrile malaria caused by Plasmodium falciparum. The drug is also effective in treating vivax malaria and malarial infections. Amodiaquine is the only drug that is effective against red-bodied Plasmodium and is ineffective against asexual and tissue-stage Plasmodium. To eliminate Plasmodium, a tissue schizonticide should be used. Amodiaquine rapidly controls fever and headache caused by the disease within 24-48 hours after taking the drug.

Amodiaquine (ADQ) is a drug used to treat malaria, including uncomplicated Plasmodium falciparum malaria. It is recommended to be taken with artesunate to reduce the risk of drug resistance.

[caption id="attachment_7478" align="alignnone" width="349"] Acrichin dihydrochloride[/caption]

Acrichin Dihydrochloride Properties

• Antimalarial: Quinacrine has historically been used as an antimalarial drug. It interferes with the parasite's DNA replication and function.
• Antiprotozoal: Effective against certain protozoal infections, including giardiasis and amoebiasis.
• Anti-inflammatory: Quinacrine exhibits anti-inflammatory properties, which contribute to its therapeutic effects in various conditions.
• Immunomodulatory: It has been used in treating autoimmune diseases like lupus erythematosus due to its immunomodulatory effects.

Acrichin Dihydrochloride Applications

• Used as a partner drug for artemisinin combination therapy
• Potential drug against SARS-COV-2
• Lupus Erythematosus: Quinacrine is used as part of the treatment regimen for systemic lupus erythematosus (SLE), often in combination with other medications.
• Malaria: Historically, it was used extensively to treat malaria, although it has largely been replaced by other antimalarials.

Mechanism of Action

Quinacrine works by intercalating into DNA, disrupting the parasite's genetic material, and inhibiting its replication and function. This action makes it effective against a variety of parasitic organisms.

Side Effects

Gastrointestinal disturbances, headaches, dizziness, and skin discoloration (yellowish tint).