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040-000-287 Acrichin Dihydrochloride, CAS 69-44-3

acrichin dihydrochloride
SKU: 040-000-287 Category:
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Synonyms Amodiaquine hydrochloride; 7-Chloro-4-(3′-diethylaminomethyl-4′-hydroxyanilino)quinoline dihydrochloride; 4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride; Quinacrine
Key words Malaria, artemisinin, Artemisia Annua Extract, COVID-19, SARS-CoV-2
Related products  Artemisinin, Piperaquine
Description

Description

Acrichin Dihydrochloride Specifications

Product Name Acrichin Dihydrochloride
CAS Registry Number 69-44-3
Molecular Formula C20H22ClN3O.2(HCl)
Molecular Weight 428.78 g/mol
Purity >99.0 %
Appearance White powder
Package 1kg-25kg
Shelf life 2 years
Functions highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax

Acrichin Dihydrochloride Description

Amodiaquine hydrochloride tablets are used to treat acute febrile malaria caused by Plasmodium falciparum. The drug is also effective in treating vivax malaria and malarial infections. Amodiaquine is the only drug that is effective against red-bodied Plasmodium and is ineffective against asexual and tissue-stage Plasmodium. To eliminate Plasmodium, a tissue schizonticide should be used. Amodiaquine rapidly controls fever and headache caused by the disease within 24-48 hours after taking the drug.

Amodiaquine (ADQ) is a drug used to treat malaria, including uncomplicated Plasmodium falciparum malaria. It is recommended to be taken with artesunate to reduce the risk of drug resistance.

acrichin dihydrochloride

Acrichin dihydrochloride

Acrichin Dihydrochloride Properties

  • Antimalarial: Quinacrine has historically been used as an antimalarial drug. It interferes with the parasite’s DNA replication and function.
  • Antiprotozoal: Effective against certain protozoal infections, including giardiasis and amoebiasis.
  • Anti-inflammatory: Quinacrine exhibits anti-inflammatory properties, which contribute to its therapeutic effects in various conditions.
  • Immunomodulatory: It has been used in treating autoimmune diseases like lupus erythematosus due to its immunomodulatory effects.

Acrichin Dihydrochloride Applications

  • Used as a partner drug for artemisinin combination therapy
  • Potential drug against SARS-COV-2
  • Lupus Erythematosus: Quinacrine is used as part of the treatment regimen for systemic lupus erythematosus (SLE), often in combination with other medications.
  • Malaria: Historically, it was used extensively to treat malaria, although it has largely been replaced by other antimalarials.

Mechanism of Action

Quinacrine works by intercalating into DNA, disrupting the parasite’s genetic material, and inhibiting its replication and function. This action makes it effective against a variety of parasitic organisms.

Side Effects

Gastrointestinal disturbances, headaches, dizziness, and skin discoloration (yellowish tint).

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