040-000-288 Chloroquine Diphosphate, CAS 50-63-5

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Synonyms N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt, N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine diphosphate
Key words COVID-19, SARS-CoV-2,
Related products  Artemisinin, Piperaquine, Acrichin Dihydrochloride
Description

Description

Chloroquine Diphosphate Specifications

Product Name Chloroquine Diphosphate
CAS Registry Number 50-63-5
Molecular Formula C18H26ClN3 · 2H3PO4
Molecular Weight 515.86 g/mol
Purity >99.0 %
Appearance White powder
Shelf life 2 years
Functions Anti-malaria

Chloroquine Diphosphate Description

Chloroquine Diphosphate salt is a member of the quinolone family and a lysosomotropic agent (accumulate inside the acidic parts of the cell). This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. Recently, chloroquine phosphate, an antimalarial drug with a history of more than 70 years, has become one of the most potentially effective drugs for the treatment of SARS-CoV-2.

chloroquine diphosphate

chloroquine diphosphate

Chloroquine Diphosphate Applications

  • Used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
  • Used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens.
  • Used to increase transfection efficiency
  • Potential drug against SARS-COV-2

Reference:

  1. Nespola, Benoît; Betz, Valérie; Brunet, Julie; Gagnard, Jean-Charles; Krummel, Yves; Hansmann, Yves; Hannedouche, Thierry; Christmann, Daniel; Pfaff, Alexander W.; Filisetti, Denis; Pesson, Bernard; Abou-Bacar, Ahmed; Candolfi, Ermanno (2015). “First case of amebic liver abscess 22 years after the first occurrence”. Parasite. 22: 20.
  2. Blessmann J, Binh HD, Hung DM, Tannich E, Burchard G (November 2003). “Treatment of amoebic liver abscess with metronidazole alone or in combination with ultrasound-guided needle aspiration: a comparative, prospective and randomized study”. Trop. Med. Int. Health.