040-000-325 Ligustrazine Hydrochloride, CAS 76494-51-4

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Synonyms 2,3,5,6-Tetramethylpyrazine hydrochloride, 2,3,5,6-Tetramethylpyrazine
Keywords Cardiovascular disease, hypertension
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Ligustrazine Hydrochloride Specifications

Product Name Ligustrazine Hydrochloride
CAS Registry Number 76494-51-4
Molecular Formula C8H12N2
Molecular Weight 136.16 g/mol
Appearance White powder
Package 1kg-25kg
Shelf life 2 years
Functions Used for ischemic stroke, chest pain, swollen pain, headache, hypertension, coronary atherosclerotic heart disease, migraine, ischemic encephalopathy, etc.

Ligustrazine Hydrochloride Description

Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.

Ligustrazine (tetramethylpyrazine) inhibits of platelet aggregation, enhances of vessel dilation, increases cerebral blood flow and possesses neuroprotective properties. The injection solution of ligustrazine has been used especially to treat ischemic stroke, coronary heart disease, diabetic nephropathy, and knee osteoarthritis. Ligustrazine was also evaluated in clinical as a remedy for pressure sores, as a salvage agent for patients with non-Hodgkin’s lymphoma, as a treatment for bronchial asthma and vertebrobasilar insufficiency.

ligustrazine hydrochloride

Ligustrazine Hydrochloride Applications

  • Pharmaceutical ingredients are used for contractile stroke, chest pain, swollen pain, headache, hypertension, coronary atherosclerotic heart disease (coronary heart disease), migraine, dilated encephalopathy, etc.


  1. Liao, S.-L., Kao, T.-K., Chen, W.-Y., et al. Tetramethylpyrazine reduces ischemic brain injury in rats. Neurosci. Lett. 372(1-2), 40-45 (2004).
  2. Wang, Y., Fu, Q., and Zhao, W. Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo. Mol. Med. Rep. 8(4), 984-988 (2013).