040-000-336 Rapamycin, CAS 53123-88-9

SKU: 040-000-336 Category:
Get A Quote





  I would like to join the mailing list to receive updates from Stanford Chemicals.

Synonyms Sirolimus, RAPA
Keywords Immunosuppressor, anti-aging, cancer
Related products Metformin (Hydrochloride), Acarbose, Dasatinib Monohydrate
Description

Description

Rapamycin Specifications

Product Name Rapamycin
CAS Registry Number 53123-88-9
Molecular Formula C51H79NO13
Molecular Weight 914.17 g/mol
Appearance White powder
Shelf life 2 years
Functions Induce autophagy, immunosuppressor, anti-aging

Rapamycin Description

Rapamycin is a macrolide compound used to cover coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has an immunosuppressive function in the human body and is particularly useful in preventing kidney transplant rejection. Rapamycin was first evaluated as an antifungal agent, but is now studied for its potent immunosuppressive and antiproliferative properties.

rapamycin

Rapamycin Applications

  • Laboratory research
  • Used as pharmaceutical ingredients for anti-rejection therapy for kidney transplantation

Reference:

  1. Kay JE, et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72: 544-549 (1991).
  2. Barbet NC, et al. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7(1): 25-42 (1996).
  3. Guba M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8(2): 128-135 (2002).
  4. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem 282(18): 13395-13401 (2007).