040-000-256 Metformin (Hydrochloride), CAS 1115-70-4

Description

Metformin Hydrochloride Specifications

Metformin Hydrochloride Description

Metformin is now a first-line agent for the treatment of type 2 diabetes, and can be used alone or in combination with sulfonylureas, thiazolidinediones or other hypoglycemic agents. It can increase the activity of AMPK and reduces blood glucose by more than 50% in mice, according to the research. In recent years, more and more research has focused on the role of metformin in cancer.

Metformin Hydrochloride Applications

• Treatment of diabetes hyperglycemia, polycystic ovary syndrome, and atherosclerosis
• Laboratory research

Reference:

1. Kim, E.K., Lee, S.H., Jhun, J.Y., et al. Metformin prevents fatty liver and improves the balance of white/brown adipose in an obesity mouse model by inducing FGF21. Mediators Inflamm. 5813030, (2016).
2. Lautatzis, ME; Goulis, DG; Vrontakis, M. Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. Metabolism: clinical and experimental. November 2013, 62 (11): 1522–34.
3. Dunn CJ, Peters DH. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs. May 1995, 49 (5): 721–49.