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  • (Discontinued) 040-000-335 Dasatinib Monohydrate, CAS 863127-77-9

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    (Discontinued) 040-000-335 Dasatinib Monohydrate, CAS 863127-77-9

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    About This Item

    Catalog No.
    040-000-335

    Discontinued

    Synonyms Dasatinib hydrate; N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide;
    Keywords Anti-aging, cancer, remove senescent cells, treatment of leukemia
    Related products Metformin (Hydrochloride), Berberine, Acarbose

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    Description

    Dasatinib Monohydrate Specifications


    Product Name Dasatinib Monohydrate
    CAS Registry Number 863127-77-9
    Molecular Formula C22H28ClN7O3S
    Molecular Weight 506.02
    Purity >97.0 %
    Appearance White powder
    Package 1kg-25kg
    Shelf life 2 years
    Functions Remove senescent cells, treatment of leukemia

    Dasatinib Monohydrate Description


    Dasatinib monohydrate is an inhibitor of Src family kinases, including c-Abl and Bcr-Abl tyrosine kinase activity. Dasatinib inhibits c-Abl and Bcr-Abl tyrosine kinase activity and shows efficacy against imatinib-resistant Bcr-Abl mutations.

    Dasatinib monohydrate is a hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia.

    dasatinib monohydrate

    Pharmacological effects of Dasatinib Monohydrate


    • Antineoplastic drugs: Substances that inhibit or prevent tumor proliferation.

    • Tyrosine kinase inhibitor: Protein kinase inhibitors that inhibit tyrosine protein kinases.

    Dasatinib Monohydrate Applications


    • Laboratory research
    • Used as a pharmaceutical ingredient of anti-cancer drugs

    Reference:


    1. Hořínková J, Šíma M, Slanař O.Prague Med Rep. 2019;120(2-3):52-63.
    2. Shah NP.Drugs Today (Barc). 2007 Jan;43(1):5-12.
    3. Palmer AK, Xu M, Tchkonia T, Kirkland JL.Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111

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