High VS. Low Molecular Weight Hyaluronic Acid


Hyaluronic acid (HA) has become a popular ingredient in skincare and supplement products due to its hydrating and anti-aging properties. However, hyaluronic acid products have disparity among each other, as they can vary in their molecular weight. High molecular weight hyaluronic acid (HMW-HA) and low molecular weight hyaluronic acid (LMW-HA) are two different types of hyaluronic acid that can be used with their own benefits and drawbacks. In this article, we will explore the differences between HMW-HA and LMW-HA. Hope that you can have a better understanding of hyaluronic acid and choose the perfect HA products for your project.


Hyaluronic Acid: Different Molecular Weight

First, let’s define what we mean by molecular weight. In chemistry, molecular weight refers to the mass of a molecule, which is determined by adding up the atomic weights of all the atoms in the molecule. In the case of hyaluronic acid, the molecular weight can vary widely, ranging from as low as 50,000 Daltons to as high as 10 million Daltons.

HMW-HA has a molecular weight greater than 1500K Daltons, much larger than LMW-HA, whose molecular weight is less than 1000k Daltons [1]. There are also Micro hyaluronic acid and mini hyaluronic acid available. Micro HA has a molecular weight range between 5k Daltons and 50k Daltons [2], even lower than mini HA, whose molecular weight range is between 100k Daltons and 1,500k Daltons [3]. Stanford Chemicals Company (SCC) is a leading supplier of hyaluronic acid of different sizes. Send us an inquiry if you are interested.

Related reading: Viscosity, Molecular Weight and Rheological Properties of HA

High VS. Low Hyaluronic Acid: Different Application Areas

LMW-HA is considered more stable than HMW-HA because of its lower tendency to undergo degradation and better oxidation resistance. Besides, LMW-HA could penetrate the skin surface easier with a lower molecular size. In a word, HMW-HA catches water molecules on the surface, while LMW-HA goes deeper underneath.

Both of them are commonly used in the cosmetic field. They are both excessively hydrating and anti-aging. You can find these hyaluronic acid products such as lotions, creams, etc. LMW-HA and HMW-HA are employed to make supplements as well. You can also combine these hyaluronic acids for your dermis and underneath.

High VS. Low Hyaluronic Acid: Different Effects

HMW-HA is valued for its excellent hydration properties and anti-aging effect. It can hold more water and provide better hydration to the skin. It can also create a film-like barrier on the skin, preventing moisture loss and protecting the skin from environmental aggressors. It is often used in skincare products to provide long-lasting hydration, improve skin texture and elasticity, and reduce the appearance of fine lines and wrinkles.

Hydrating Effect

In contrast, LMW-HA is known for its anti-inflammatory benefits, as it can reduce redness, irritation, and inflammation in the skin. LMW-HA can penetrate the skin more easily. Additionally, it can stimulate the production of collagen and elastin, which are essential for cell growth and differentiation.


So, select hyaluronic acid products according to your skincare goals and concerns. If your primary concern is hydration and anti-aging, then HM-WHA may be the better choice for you. On the other hand, if you are dealing with inflammation, redness, or acne-prone skin, then LMW-HA may be the better choice.

Related reading: Health Benefits of hyaluronic Acid for Skin


It’s important to note that not all HA products will list their molecular weight on the label. If you are unsure which type of HA is used in a product, you can do some research or reach out to the manufacturer for more information.

In addition to molecular weight, other factors can impact the effectiveness of hyaluronic acid products. The concentration of HA, the delivery method, and other ingredients in the product can all affect how well the product works.


In summary, high molecular weight hyaluronic acid and lower molecular weight hyaluronic acid differ in their effects and use areas.

HMW-HA is better for providing hydration and anti-aging benefits for cells on the surface, while LMW-HA is better for reducing inflammation and improving deeper skin texture.

Stanford Chemicals Company has rich experience in the manufacture and sales of high molecular weight, middle molecular weight, and low molecular weight hyaluronic acid. It’s important to choose a product that is well-formulated and suited to your specific skincare needs to ensure the best results. Please check our homepage for more information.



[1] Özdemir, H., & Özdemir, Ö. (2018). Hyaluronic acid: A literature review. In K. Schröder, S. S. Suleman, & L. Ahmad (Eds.), Polysaccharides and Nanocarriers for Drug Delivery and Pharmaceutical Applications (pp. 59-73). Springer.

[2] Guo, H., Jiang, Q., Zhang, L., Feng, R., & Li, X. (2018). Micro- and nano-sized hyaluronan: A comparative study of their in vitro uptake and biological activities. International Journal of Biological Macromolecules, 107(Pt A), 683-691. doi: 10.1016/j.ijbiomac.2017.09.026

[3] Papakonstantinou, E., & Roth, M. (2019). Hyaluronic acid: A comprehensive review. Journal of Cosmetic Dermatology, 18(2), 310-317. doi: 10.1111/jocd.12732

April 4, 2023 Hyaluronic Acid, Skin Care , , ,
About Cathy

Cathy Leenerts graduated from Ohio State University majoring in applied chemistry. She has been writing about various materials for three years at Stanford Advanced Materials (SAM). She is committed to providing brief and accurate articles for readers. Comments and emails are welcome.

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