Sodium Hyaluronate for Skin

Sodium Hyaluronate can be found abundantly in the dermis, helping skin retain its moisture.

The skin remains hydrated and the surface is supple when the skin contains adequate concentrations of hyaluronic acid.

Sodium Hyaluronate for Joint

Joint fluid and articular cartilage contain hyaluronic acid at high concentrations. HA serves as a lubricant (preventing bone-to-bone friction) and as a cushion. This function allows our joints to move smoothly.
A joint function-improving agent with hyaluronic acid as its active pharmaceutical ingredient is a prescription drug.

Sodium Hyaluronate is injected into joints to treat patients suffering from knee osteoarthritis, periarthritis of the shoulder (also known as frozen shoulder syndrome), and knee pain from rheumatoid arthritis. Hyaluronic acid has been reported to have anti-inflammatory and pain-relieving effects in such uses.

Sodium Hyaluronate for Eyes

The vitreous body contains high concentrations of Sodium Hyaluronate, which provides cushioning and plays a role in maintaining the shape of the eyeball.

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Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissues in the human body.

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer consisting of the disaccharide unit of sodium glucuronide-N-acetylglucosamine. It can bind to specific receptors with high affinity.

The polyanionic form, commonly referred to as hyaluronic acid, is a viscoelastic polymer found in the atrial and vitreous humor of the eye and in joint fluids.

Sodium hyaluronate, as hyaluronic acid, is widely distributed in the extracellular matrix of mammalian connective, epithelial, and neural tissues, as well as in the corneal endothelium.

Sodium hyaluronate acts as a tissue lubricant and is thought to play an important role in regulating interactions between adjacent tissues. It forms a viscoelastic solution in water. The high viscosity of the solution provides mechanical protection to the tissues (iris, retina) and cell layers (cornea, endothelium, and epithelium).

The elasticity of the solution helps absorb mechanical stress and provides protective cushioning for the tissues. In promoting wound healing, it is believed to act as a protective transport vehicle, bringing peptide growth factors and other structural proteins to the site of action. It then enzymatically degrades and releases active proteins to promote tissue repair.

Sodium Hyaluronate for Skin

1, Medium molecular weight sodium hyaluronate

Highly effective in moisturizing and lubricating the skin.

2, High molecular weight sodium hyaluronate

Excellent moisturizing and film-forming properties, efficient thickening effect, and enhanced lubricating sensation when applying the product.

3, Sodium Oligomeric Hyaluronate

Efficient moisturizing and lubricating effect on the skin. Enzymatic cutting process, molecular weight less than 10000, real transdermal absorption, deep moisturizing, anti-aging, after-sun repair.

4, Low molecular weight sodium hyaluronate

Nourish the skin, breathable and moisturizing, will not bring any sticky skin feeling.

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Sodium hyaluronate is one of the components of human skin and the most widely distributed acidic mucose in the human body. It exists in the matrix of connective tissue and has a good moisturizing effect.

Effect of sodium hyaluronate

1. Improving pharmacodynamics

Hyaluronic acid is the main component of connective tissue such as the human interstitium, vitreous body, and synovial fluid. It has the characteristics of keeping water, maintaining extracellular space, regulating osmotic pressure, lubricating, and promoting cell repair in vivo. As a carrier of ophthalmic drugs, it can prolong the retention time of drugs on the eye surface by increasing the viscosity of eye drops, improving the bioavailability of drugs, and reducing the irritation of drugs to the eyes.

The adjuvant therapy can be injected directly into the articular cavity as a lubricant for the treatment of arthritis, such as SPIT injection.

2. Crease Resistance of Sodium Hyaluronate

The moisture level of the skin is closely related to the content of hyaluronic acid. With the increase in age, the content of hyaluronic acid in the skin decreases, which weakens the water-retaining function of the skin and produces wrinkles. Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity.

When applied to the skin’s surface, it can form a moisture-permeable film to keep the skin moist and shiny. Small molecule hyaluronic acid can penetrate into the dermis, promote blood microcirculation, help the skin to absorb nutrients, and play a cosmetic and anti-wrinkle health role.

3. Moisturizing effect of sodium hyaluronate

The moisturizing effect is the most important role of sodium hyaluronate in cosmetics. Compared with other moisturizers, the relative humidity of the surrounding environment has less influence on its moisturizing effect. The results show that sodium hyaluronate has the highest moisture absorption at low relative humidity (33%) and the lowest moisture absorption at high relative humidity (75%) compared with common moisturizers. This unique nature is adapted to the skin in different seasons, different environmental humidity, such as dry winter and wet summer, and the requirements of cosmetics moisturizing effect. The moisture retention of sodium hyaluronate is related to its mass and molecular weight.

4. Nutritional effects of sodium hyaluronate

Hyaluronic acid is an inherent biological substance in the skin, and exogenous sodium hyaluronate is a supplement to endogenous sodium hyaluronate in the skin. Sodium hyaluronate with low quality can penetrate into the skin epidermis, promote the supply of skin nutrition and waste excretion, thus preventing skin aging, and play a role in cosmetology and beauty. Skin maintenance is more important than other cosmetics and has become the modern people’s desire to maintain face consciousness.

5. Repair and prevention of skin damage caused by sodium hyaluronate

Skin burned by sunlight, such as reddening, blackening, peeling, etc., is mainly burned by ultraviolet rays in sunlight. Sodium hyaluronate can promote the regeneration of the injured skin by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen-free radicals.

Pre-use also has a preventive effect. Its mechanism of action is different from the ultraviolet absorbent commonly used in sunscreen. Therefore, hyaluronic acid and ultraviolet absorbent in sunscreen skincare products have a synergistic effect, which can reduce the transmission of ultraviolet rays and repair the skin damage caused by a small number of ultraviolet rays, thus playing a dual protective role.

The combination of sodium hyaluronate and EGF (epidermal growth factor) can accelerate the regeneration of epidermal cells and make the skin tender, smooth and elastic. When the skin suffers from mild burns and scalds, the application of water cosmetics containing sodium hyaluronate on the surface can alleviate pain and accelerate the healing of the wounded skin.

6. Lubrication and film formation of sodium hyaluronate

Sodium hyaluronate is a kind of polymer with strong lubrication and film-forming properties. Skincare products containing sodium hyaluronate have obvious lubrication and good hand feeling when applied. When applied to the skin, a film can be formed on the surface of the skin, which makes the skin feel smooth and moist, and protects the skin. Haircare products containing sodium hyaluronate can form a layer of film on the surface of the hair, which can moisturize, lubricate, protect hair, eliminate static electricity, and make the hair easy to comb, elegant, and natural.

7. Thickening of sodium hyaluronate

Sodium hyaluronate has a high viscosity in an aqueous solution, and 1% of its aqueous solution is gelatinous. It can play a role in the thickening and stabilization of cosmetics.

8. Pharmacological effects of sodium hyaluronate

Physiological active substances widely exist in animals and humans and are distributed in human skin, synovial fluid of joints, umbilical cord, aqueous humor, and vitreous body of eyes. Molecular weight is 500000-730000 Dalton. Its solution has high viscoelasticity and imitation. It is an adjuvant for ophthalmic surgery. It maintains a certain depth of the anterior chamber after injection into the anterior chamber, which is convenient for operation. It also protects corneal endothelial cells and intraocular tissues, reduces complications, and promotes wound healing.

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