Finding the right skincare ingredients can feel like navigating a minefield, especially for those of us with acne-prone skin. We’re on a perpetual quest for products that promise hydration without exacerbating our acne. Enter hyaluronic acid (HA) powder, a skincare ingredient that’s been getting a lot of buzz. But is it suitable for acne-prone skin? Let’s discuss the details.

What Is Hyaluronic Acid?

Hyaluronic acid is a naturally occurring substance in our skin, known for its stunning ability to hold up to 1000 times its weight in water. This superhero ingredient helps keep our skin hydrated, plump, and youthful-looking.

When we talk about HA in powder form, it’s essentially a dehydrated version that, when reconstituted, offers all the hydrating benefits of its liquid counterparts but with the flexibility of dosage and application.

Is Hyaluronic Acid Powder Ideal for Acne-Prone Skin？

Acne-prone skin often suffers from a paradoxical combination of excess oil and dehydration. This imbalance can lead to increased oil production, clogged pores, and ultimately, more acne. Here’s where hyaluronic acid powder steps in. It provides the skin with much-needed hydration without adding any oily residue or weight, making it an ideal ingredient for those battling acne.

–Benefits of Hyaluronic Acid Powder for Acne-Prone Skin

Hyaluronic acid powder offers a variety of advantages for acne-prone skin:

• Hydration without Heaviness: HA powder attracts and retains moisture in the skin without contributing to an oily complexion. This hydration is crucial for repairing the skin’s barrier, making it less susceptible to acne-causing bacteria and irritants.
• Soothing Effects: Beyond its hydrating capabilities, hyaluronic acid has natural soothing properties that can help reduce skin redness and irritation, often associated with acne breakouts.
• Enhancing Skin Barrier: A healthy skin barrier is essential for keeping out harmful bacteria and pollutants that can exacerbate acne. HA powder strengthens this barrier, providing an extra layer of protection for your skin.
• Supports Skin Healing: The anti-inflammatory properties of hyaluronic acid are beneficial in soothing irritated skin and reducing redness associated with acne. Additionally, by promoting a healthier skin barrier, HA aids in the skin’s natural repair process. This accelerates the healing of existing acne lesions and can contribute to a reduction in acne scarring over time.

–How to Incorporate HA Powder into Your Skincare Routine?

Incorporating HA powder into your skincare regimen is straightforward. You can mix it with your favorite serum or moisturizer to enhance its hydrating properties. Apply it to damp skin to lock in moisture effectively. Remember, a little goes a long way, so start with a small amount and adjust as needed.

Transformations: Real-Life Hyaluronic Acid Successes

Let’s continue to explore the multiple benefits of hyaluronic acid with specific cases and reports. The following real-life transformations achieved through cutting-edge HA-based treatments for acne scarring showcase the ingredient’s potential in both preventive care and targeted cosmetic interventions.

1. Background: Acne scarring, a widespread and complex aesthetic concern, often necessitates the use of various treatment methods. A novel strategy employing microdoses of a low-viscosity, non-animal sourced hyaluronic acid (NASHA) dermal filler injected into the mid-to-superficial layers of the dermis shows promise for enhancing the appearance of depressed acne scars.

2. Materials and Methods: A group of twelve patients, each with moderate to severe acne scarring who had previously undergone a series of fractional laser resurfacing treatments, received microinjections of a 20 mg/mL hyaluronic acid (HA) gel directly into specific depressed acne scars on their faces.

3. Results: All treated lesions displayed immediate visual improvement post-treatment. The procedure was received well by patients, with adverse events limited to minor, transient pinpoint bleeding at the sites of injection.

4. Conclusion: The technique of microinjecting low-viscosity HA into depressed acne scars is an effective and valuable method for treating these types of scars, offering immediate enhancements in their appearance. [1]

It is also reported that Hyaluronic Acid Fillers (HAF) enhance aesthetic appeal while offering promising therapeutic benefits in facial rehabilitation. This is supported by a thorough review of literature conducted up to December 2022, which examined a wide range of clinical studies.

The findings reveal the effectiveness of HAF in addressing various conditions, including facial asymmetry, different types of scars, jawline refinement, earlobe repair, periocular and oral enhancements, nasal obstructions, and morphea en coub de saber.[2]

Conclusion

For those of us with acne-prone skin, hyaluronic acid powder offers a beacon of hope. Its unique ability to provide intense hydration without clogging pores or adding oil makes it an invaluable addition to any skincare routine. Whether you’re battling constant breakouts or looking to improve your skin’s overall health, HA powder might just be the ingredient you’ve been searching for.

Have you tried hyaluronic acid powder in your skincare routine? We’d love to hear about your experiences! Let’s have a better experience in the treatment of acne with Stanford Chemicals (SCC) for clearer, healthier skin together!

Reference:

[1] Shlomit Halachmi, MD PhD,^a Dan Ben Amitai MD,^b,d and Moshe Lapidoth MD MPH(2013). Treatment of Acne Scars With Hyaluronic Acid: An Improved Approach. The Journal of Drugs in Dermatology (JDD). https://jddonline.com/articles/treatment-of-acne-scars-with-hyaluronic-acid-an-improved-approach-S1545961613P0121X

[2] Wollina, U.; Kocic, H.; Goldman, A. Hyaluronic Acid in Facial Rehabilitation—A Narrative Review. Cosmetics 2023, 10, 61. https://doi.org/10.3390/cosmetics10020061

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Scars tell stories—reminders of the body’s incredible healing ability after injury or surgery. However, for many, these marks may cause self-consciousness or discomfort. Fortunately, science offers a remarkable solution in the form of hyaluronic acid. HA is a substance renowned for its potential to reduce scars and rejuvenate skin. Here, this article offers a comprehensive understanding of how hyaluronic acid can be a game-changer in scar reduction and skin rejuvenation!

Hyaluronic Acid for Scar Reduction

Understanding Hyaluronic Acid

Hyaluronic acid is often termed the “fountain of youth.” It is a naturally occurring substance in the human body, and it is primarily found in the skin, connective tissues, and eyes. It plays a crucial role in maintaining moisture, promoting elasticity, and supporting tissue repair.

Related reading: 10 Things All Guys Should Know about Hyaluronic Acid

The Role of Hyaluronic Acid in Scar Reduction

When the skin undergoes injury or trauma, the body initiates a healing process that includes the formation of scars. Hyaluronic acid intervenes in this process. It regulates tissue hydration and inflammation. It also fosters an optimal environment for scar healing.

1.    Moisture Retention and Scar Healing

One of hyaluronic acid’s remarkable attributes is its ability to retain moisture. By holding up to 1,000 times its weight in water, it helps keep the skin adequately hydrated during the healing phase. This moisture retention aids in preventing scars from becoming dry and rigid, promoting softer, more pliable scar tissue.

2.    Promoting Skin Elasticity and Texture

Scars often alter the skin’s texture and elasticity. This leads to a rough or uneven appearance. Hyaluronic acid contributes to skin hydration and elasticity. This helps smoothen the scar tissue, improve its overall texture, and make it less conspicuous and more akin to the surrounding skin.

3.    The Collagen Connection

Collagen is a protein crucial for skin structure. It tends to be disrupted during scar formation. Hyaluronic acid encourages collagen synthesis and aids in the restructuring of scar tissue. This process can lead to a more uniform and aesthetically pleasing appearance of the scar over time.

Related reading: Hyaluronic Acid for Acne Scars Treatments

Clinical Applications and Treatments

Medical professionals frequently employ hyaluronic acid-based treatments to address various types of scars, including surgical scars, acne scars, and keloids. These treatments may include topical applications or injections. In some cases, doctors incorporate it into dressings or gels for sustained release over the scarred area.

Numerous studies explore the impact of hyaluronic acid (HA). One such research endeavor unveiled a pioneering silicone gel blend that merged HA and salts with polysiloxane derivatives. The goal was to elevate the efficacy of scar prevention and amelioration. This innovative gel was assessed using Wistar rats. It demonstrated promising physical and chemical traits alongside notable anti-scar capabilities. [1]

Another study focused on the treatment of keloid scarring. Keloids are characterized by increased growth factor signaling, hyperproliferation, and reduced hyaluronic acid (HA) deposition in the extracellular matrix (ECM). Using high molecular weight HA, the researchers treated five keloid fibroblast cultures and one normal culture for 72 hours.

Results showed reduced proliferation in one keloid culture (KF3), decreased pro-collagen I expression in another (KF2) with modified collagen fiber arrangement, and downregulation of TGF-b1 growth factor expression in KF3 and KF4. Additionally, HA decreased active TGF-b1 release in KF2 and KF5. The findings suggest that high molecular weight HA has the potential to normalize keloid fibroblast features. So, HA offers promise in reducing fibrosis and mitigating keloid manifestations based on specific genotype variations within keloid fibroblast cell lines. [2]

Benefits and Considerations

The use of hyaluronic acid in scar reduction offers several advantages. It’s well-tolerated by most individuals. So, HA minimizes the risk of adverse reactions due to its natural presence in the body, and it typically produces gradual but noticeable improvements in scar appearance.

However, it’s essential to note that while hyaluronic acid treatments can significantly diminish the appearance of scars, complete elimination might not always be feasible. Additionally, individual responses to treatment may vary, requiring personalized approaches for optimal results.

Conclusion

Hyaluronic acid stands as a promising ally in the journey toward scar reduction and skin rejuvenation. Its ability to improve moisture retention, enhance skin texture, and promote collagen production marks it as a valuable component in scar management.

For those seeking to diminish the visibility of scars and restore skin confidence, please consult with a dermatologist or healthcare professional experienced in hyaluronic acid-based treatments. This paves the way toward achieving smoother, more supple skin and reduces the prominence of scars.

Stanford Chemicals Company (SCC) stands as a premier wholesale supplier of pure organic hyaluronic acid (HA) in the USA. We focus on medical-grade, cosmetic-grade, and food-grade HA. Our sodium hyaluronate powder is non-animal derived, ensuring it is Vegan-friendly and compliant with kosher standards. Trust our extensive expertise and varied offerings to meet your specific hyaluronic acid needs across diverse industries and applications.

Reference:

[1] Md. Shoaib Alam, Arif Ansari, Iftikhar Ahsan, Sheikh Shafiq-un-Nabi, Shadab Md, Rasheed A. Shaik, Basma G. Eid, Mohammad Zaki Ahmad, Javed Ahmad (2023). Topical gel containing Polysiloxanes and hyaluronic acid for skin scar: Formulation design, characterization, and In vivo activity. Journal of Cosmetic Dermatology, 22(4), 1220-1232. https://doi.org/10.1111/jocd.15574

[2] Hoffmann A, Hoing JL, Newman M, Simman R. Role of Hyaluronic Acid Treatment in the Prevention of Keloid Scarring. J Am Coll Clin Wound Spec. 2013 Jul 1;4(2):23-31. doi: 10.1016/j.jccw.2013.06.001. PMID: 24936445; PMCID: PMC4054787.

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The intricate mechanisms of vision rely not only on the complexity of the eye but also on the nutrients that support its function and vitality. Among these vital nutrients, vitamins and hyaluronic acid stand out. They are essential elements in preserving and enhancing eye health. Their collective role extends beyond mere sustenance, delving into maintenance, protection, and the potential improvement of ocular well-being. Let’s have a detailed discussion about their features and uses.

Healthy Vision [1]

Vitamins: Nourishment for Optimal Eye Function

–Vitamin A: The Vision Vitamin

Vitamin A is renowned for its role in vision. It plays a crucial part in the structure of the eye. It contributes to the production of rhodopsin. That is a pigment found in the retina essential for low-light and color vision. Insufficient vitamin A intake may lead to night blindness and other vision impairments.

–Vitamin C: An Antioxidant Shield

As a potent antioxidant, Vitamin C safeguards the eyes from oxidative stress. In this way, it reduces the risk of age-related macular degeneration (AMD) and cataracts. Its presence in the eye’s tissues supports collagen synthesis and helps maintain the cornea and blood vessels.

–Vitamin E: Shielding Against Age-Related Issues

Vitamin E is another powerful antioxidant. It protects cells in the eyes from free radicals, so it potentially reduces the risk of cataracts and AMD. It collaborates with Vitamin C to fortify the eye’s defense against oxidative damage.

Hyaluronic Acid: Moisture and Support for Eye Health

–Hydration and Lubrication

Hyaluronic acid is noted for its moisture-retaining properties. These features contribute significantly to ocular hydration. It supports the maintenance of the eye’s moisture levels and ensures adequate lubrication for optimal comfort and clarity of vision.

–Eye Tissue Health

Beyond hydration, hyaluronic acid supports the health of eye tissues. Found in the vitreous humor and other ocular structures, it aids in maintaining the structural integrity of the eye and may potentially support healing after injuries.

Related reading: Best Companions of Hyaluronic Acid for Skincare

The Synergistic Benefits

Combining these essential vitamins with hyaluronic acid in supplements could offer synergistic benefits for eye health. While a balanced diet is crucial, supplements provide an additional means of ensuring adequate intake, especially for those with specific dietary restrictions or deficiencies.

Other Active Ingredients for Eye Health

Maintaining optimal eye health involves a combination of various nutrients and compounds. Here are some other key active ingredients known for their potential benefits in promoting eye health:

1. Lutein and Zeaxanthin:

• Benefits: These carotenoids are found in high concentrations in the retina and help protect the eyes from harmful high-energy light waves like ultraviolet rays. They may reduce the risk of age-related macular degeneration (AMD) and cataracts.
• Food Sources: Leafy green vegetables, eggs, and certain fruits.

2. Omega-3 Fatty Acids:

• Benefits: DHA (docosahexaenoic acid) is a type of omega-3 fatty acid. It is a major structural component of the retina. Omega-3s may help prevent dry eyes and support overall eye health.
• Food Sources: Fatty fish (salmon, trout, mackerel), chia seeds, flaxseeds, and walnuts.

3. Zinc:

• Benefits: Zinc is essential for the health of the retina and may help prevent AMD and night blindness. It plays a role in transporting Vitamin A from the liver to the retina.
• Food Sources: Meat, dairy products, nuts, and whole grains.

4. Zeaxanthin and Astaxanthin:

• Benefits: Similar to lutein, zeaxanthin, and astaxanthin are carotenoids with antioxidant properties. They may contribute to protecting the eyes from oxidative stress.
• Food Sources: Zeaxanthin can be found in kale, spinach, and collard greens, while astaxanthin is present in salmon, shrimp, and microalgae.

Dosage and Safety

Here are the recommended dosage and upper limits for some common vitamins for adults:

Take the case of Vitamin A (Retinol and Beta-Carotene). Its Recommended Dietary Allowance (RDA) or Daily Adequate Intake (AI) is 700 micrograms (2,333 IU) for women and 900 micrograms (3,000 IU) for men. And the Upper Limit is 3,000 micrograms (about 10,000 IU). [2]

Yet, before introducing new supplements or making significant dietary changes, it’s advisable to consult with an eye care professional or healthcare provider. They can provide personalized advice based on individual needs and any existing eye health conditions. In this way, you can achieve optimal eye health benefits without adverse effects.

Ultimately, a holistic approach that combines a nutritious diet, regular eye check-ups, and appropriate supplementation lays the foundation for clearer, healthier vision and sustained eye wellness throughout life’s journey.

Conclusion: A Visionary Approach to Eye Health

In the intricate symphony of vision, vitamins and hyaluronic acid emerge as key players. Each contributes unique elements crucial for maintaining eye health and function. While these nutrients cannot reverse severe eye conditions, their inclusion in a well-rounded diet or through supplements underscores their importance in supporting ocular vitality and potentially mitigating certain age-related issues.

Explore our comprehensive selection of hyaluronic acid powders crafted for skincare and eye health at Stanford Chemicals Company (SCC). Discover a range of grades and molecular weights tailored to meet your specific business or research needs. Visit our website to find the perfect HA products to elevate your skincare formulations. Send us an inquiry if you are interested.

Reference:

[1] Centers for Disease Control and Prevention (2020, October 1). Keep an Eye on Your Vision Health. Centers for Disease Control and Prevention. Retrieved December 7, 2023, from https://www.cdc.gov/visionhealth/resources/features/keep-eye-on-vision-health.html

[2] Harvard T.H. Chan School of Public Health (2023, March 7). Vitamins and Minerals. Harvard T.H. Chan School of Public Health. Retrieved December 7, 2023, from https://www.hsph.harvard.edu/nutritionsource/vitamins/

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The skincare industry has witnessed a whirlwind of change, especially with the rise of Alpha Hydroxy Acids (AHAs) and their remarkable effects on skin health. It is said that Cleopatra indulged herself in sour milk (lactic acid) baths for radiant skin. This is a historic nod to the potential of AHAs. Recently, these acids have created a buzz in the beauty and cosmetic realm as well. Let’s have a detailed discussion about their properties and benefits.

What are alpha hydroxy acids?

AHAs are a group of naturally occurring acids primarily derived from fruits and milk sugars. These acids are well-known for their ability to exfoliate the skin and promote skin cell turnover. Here’s a glimpse of some of the top Alpha Hydroxy Acids:

Structures of Different AHAs [1]

• Lactic Acid: It is an exceptional exfoliant and potent moisturizer. It often comes from non-dairy sources like plants.
• Glycolic Acid: Glycolic acid is derived from sugar cane and fruits. It immediately softens the skin upon application.
• Citric Acid: The source of citric acid is from citrus fruits. It aids collagen function and is crucial for skin elasticity.
• Malic Acid: It is found in apples. It enhances skin elasticity, so it is ideal for homemade skincare.
• Tartaric Acid: This acid is extracted from grapes and citrus fruits. It enhances skin flexibility and has become a popular choice in AHA skincare.

Related reading: The Secrets of Skincare: Glycolic Acid, Lactic Acid, and Hyaluronic Acid

How do AHA exfoliants work for the skin?

AHA exfoliants work by loosening and removing dead skin cells from the skin’s surface. They can penetrate the skin’s outermost layer, revitalize the skin, and impart a youthful radiance. Users often report several noticeable benefits:

• Exfoliation: AHAs work by breaking down the bonds between dead skin cells on the outermost layer of the skin (epidermis). This chemical exfoliation helps reveal fresher, smoother, and brighter skin underneath.
• Promotion: AHAs promote skin cell turnover because new skin cells are produced and brought to the skin’s surface. This turnover helps in maintaining healthier-looking skin and improving its texture.
• Collagen Production: Some AHAs, such as glycolic acid, have been found to stimulate collagen production in the skin. Collagen provides structure and firmness to the skin.
• Hydration: AHAs can also improve the skin’s ability to retain moisture. These acids can assist in maintaining a hydrated and smoother skin surface.

Is there any FDA research on the safety of AHAs?

In the short term, excessive doses and improper usage of AHA-containing skincare products may result in adverse reactions. Between 1992 and February 2004, there were 114 reported cases. They detail various dermatologic experiences associated with these products. The most frequently reported reactions included burning sensations (45), rash or dermatitis (35), swelling (29), pigmentary changes (15), and blisters (14). [2] Therefore, it is necessary to follow proper usage guidelines and dosage recommendations when integrating AHAs into skincare regimens.

In the long term, the FDA collaborated with the National Toxicology Program (NTP) to assess the safety of prolonged AHA use. Their study revealed that glycolic acid, an AHA, did not induce the development of cancer cells in mice. Additionally, salicylic acid, another common AHA, safeguarded mice against the effects of light exposure. [2] These findings contribute to a broader understanding of the safety profile associated with extended AHA usage.

How can AHAs be used safely?

When it comes to Alpha Hydroxy Acids, proper usage is crucial. Generally, AHA ingredients range from 1% to 2% for daily products. For more intensive treatments, 5% to 10% AHA concentration should suffice. However, these products should be used judiciously. The frequency should be limited to once a week.

Using products containing AHAs may increase the skin’s sensitivity to the sun. Hence, to safeguard against such potential adverse effects, it’s recommended to use a broad-spectrum sunscreen daily. You’d better choose a sunscreen with a high SPF. This precautionary measure helps minimize the risk of sun damage and supports overall skin health when using AHAs regularly.

Which ingredients work well with AHAs?

When incorporating AHAs into your skincare routine, it’s essential to be cautious about mixing them with certain active ingredients to prevent adverse reactions. Compatible ingredients include hydrating elements like hyaluronic acid or moisturizing agents such as ceramides and glycerin. Nevertheless, it’s important to avoid combining AHAs with retinoids, benzoyl peroxide, or other exfoliants to prevent skin irritation or over-exfoliation. Always perform a patch test and introduce new products gradually to ensure compatibility and minimize the risk of any adverse reactions.

Related reading: Best Companions of Hyaluronic Acid for Skincare

Conclusion

In a word, AHAs stand out for their exfoliating prowess and offer a multitude of benefits for skin care. When used thoughtfully and in tandem with compatible ingredients, they can unlock a path to healthier, rejuvenated skin. Please use them with professional guidance to harness the transformative potential of AHAs while prioritizing skin safety and wellbeing.

Stanford Chemicals Company (SCC) provides a range of hyaluronic acid powder options. HA products tailored for specific skincare purposes are also available. Please check out our website for detailed information about different grades of HA products.

Reference:

[1] Tang S-C, Yang J-H. Dual Effects of Alpha-Hydroxy Acids on the Skin. Molecules. 2018; 23(4):863. https://doi.org/10.3390/molecules23040863

[2] U.S. Food and Drug Administration (2022, November 22). Alpha Hydroxy Acids. U.S. Food and Drug Administration. Retrieved November 29, 2023, from https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids#:~:text=product%20contains%20AHAs%3F-,Why%20are%20AHAs%20used%20in%20some%20cosmetics%3F,improving%20skin%20condition%20in%20general.

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Skincare ingredients complement each other and elevate the effectiveness. Although hyaluronic acid (HA) is known for its exceptional hydration, it turns more powerful in the company of several potent allies.

Skincare Products

Here, this article is going to discuss these best companions. Hope that you can learn more about moisture-retaining glycerin, barrier-boosting ceramides, collagen-stimulating peptides, and most importantly, the hydrating hyaluronic acid.

Best Companions of Hyaluronic Acid: Glycerin, Ceramides, and Peptides

Let’s first start with several “besties” that work exceptionally well together with hyaluronic acid. Here are some of HA’s skincare best companions:

1. Glycerin—Humectant and Emollient: Glycerin is also called glycerol. It is a colorless, odorless, and syrupy liquid with various functions in skincare and cosmetics. First, it is known for its humectant properties. Namely, glycerin attracts and retains water for the skin. Additionally, thanks to its emollient nature, it softens and smooths the skin’s surface. Therefore, it has become a versatile ingredient in skincare formulations.
2. Ceramides—Skin Barrier: Ceramides are lipid molecules found naturally in the skin’s outermost layer, the stratum corneum. They play a crucial role in maintaining the skin barrier. They help to retain moisture, regulate hydration, and protect against environmental aggressors. Such a skin barrier function contributes to skin resilience, suppleness, and overall skin health.
3. Peptides for Skin Firmness: Peptides are short chains of amino acids, the building blocks of proteins. They play essential roles in various biological functions. In skincare, peptides are used for their ability to signal cells to perform specific tasks, such as producing collagen. These small protein fragments can target various skincare concerns like fine lines, wrinkles, and skin texture. In these ways, peptides enhance skin firmness and elasticity.

Best Companions of Hyaluronic Acid: Versatile Vitamins

Alongside these allies, a variety of vitamins and acids join forces to tackle skincare concerns.

4. Anti-Aging Retinol: Retinol is a derivative of vitamin A. This powerful ingredient is celebrated for its anti-aging properties. It aids in skin cell turnover, and promotes the emergence of newer, healthier cells while diminishing the appearance of fine lines, wrinkles, and uneven skin tone. It stimulates collagen production as well. However, it can cause skin sensitivity and increased sun sensitivity. So, diligent use of sunscreen is recommended.
5. Tretinoin—Acne Treatment: Tretinoin is another derivative of vitamin A. Tretinoin needs a prescription, while retinol is a milder over-the-counter derivative. It functions as a retinoid. That is to say, it can stimulate skin cell turnover, improve skin texture, and mitigate signs of aging. Despite its effectiveness, it has the potential to cause skin sensitivity and sun sensitivity. Consult a dermatologist for guidance on proper application, please.
6. Niacinamide—A Versatile Vitamin: Niacinamide is also known as vitamin B3. This versatile skincare ingredient has numerous benefits. It helps strengthen the skin barrier. With anti-inflammatory properties, it soothes irritated or sensitive skin, minimizes redness, and regulates oil production. Also, it aids in reducing the appearance of enlarged pores.
7. Vitamin B5–Soother and Moisture Skin: Vitamin B5 or pantothenic acid is a water-soluble vitamin. It serves as a natural humectant, promotes hydration, and supports the skin barrier. It is also valued for its ability to soothe and nourish the skin.
8. Vitamin C—Brightener Skin: Vitamin C, or ascorbic acid, is a potent antioxidant for skin health. It helps protect the skin from free radical damage caused by UV exposure, pollution, and other environmental stressors. With notable brightening properties, it promotes a more even skin tone and reduces the appearance of dark spots. It aids in collagen synthesis as well.
9. Vitamin E—A Powerful Antioxidant: Vitamin E is a fat-soluble antioxidant. It shields the skin from oxidative stress and helps to combat signs of premature aging. It also supports skin repair and acts as a moisturizer. It can reduce inflammation as well.

Related reading: 3 Types of Promising Skincare Ingredients: Bamboo Extract, Vitamin B5, and Sodium Hyaluronate

Best Companions of Hyaluronic Acid: Various Acids

10. Alpha Hydroxy Acids (AHAs)–Exfoliation: AHAs are water-soluble acids derived from fruits, milk, or plants. For example, glycolic acid comes from sugar cane, while lactic acid is from milk. These acids remove dead skin cells and promote cell turnover. Thus, AHAs help improve skin texture, reduce the appearance of fine lines, wrinkles, and hyperpigmentation, and enhance overall skin radiance.
11. Beta Hydroxy Acids (BHAs) and Exfoliation: BHAs, such as salicylic acid, are oil-soluble acids. These acids address skin concerns at a deeper level. BHAs effectively exfoliate the skin’s surface and deep within pores, so they are beneficial for treating acne-prone or oily skin. Salicylic acid is the most common BHA. It helps unclog pores, reduce inflammation, and break down excess oil.
12. Azelaic Acid for Acne and Dark Spots: This acid is a skincare ingredient with multifunctional properties. It helps treat acne by reducing inflammation and eliminating bacteria. Besides, azelaic acid is effective in reducing hyperpigmentation, evening out skin tone, and minimizing the appearance of dark spots or melasma. It’s also recognized for its gentle exfoliating effects.
13. Ferulic Acid–A Potent Antioxidant: It is found in various plant-based sources. In skincare, it can enhance the stability and effectiveness of other antioxidants like vitamins C and E. In addition, it aids in skin cell regeneration and has anti-inflammatory properties.

Related reading: The Secrets of Skincare: Glycolic Acid, Lactic Acid, and Hyaluronic Acid

Best Companions of Hyaluronic Acid: Quality Products

There are many more skincare besties that pair well with hyaluronic acid. All of them can lead to a tailored skincare routine catering to hydration, protection, and overall skin well-being (See Table 1). Nevertheless, it’s essential to patch-test new products and put them gradually into your routine to ensure compatibility and effectiveness.

Stanford Chemicals Company (SCC) offers quality hyaluronic acid powder for skincare. Different grades and molecular weights are available. Please visit our website for the perfect HA products for your business or research.

Table 1 Best Companions of Hyaluronic Acid

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Joint health is a vital aspect of overall well-being because it directly impacts our mobility and quality of life. Whether you’re an athlete aiming to shield your joints from injury or an individual searching for relief from joint discomfort, there is a range of substances and supplements that can contribute to enhancing and preserving joint health. In this article, we explore some common substances known for their potential benefits in promoting joint health.

1. Glucosamine:

• What is it: Glucosamine is a naturally occurring compound in the body. Its highest concentration is in cartilage.
• How it helps: Glucosamine plays a vital role in maintaining joint structure and function. This supplement is often used to alleviate joint pain and enhance joint flexibility, so it has become a popular choice for individuals with osteoarthritis.

Chemical Structure of Glucosamine [1]

Chondroitin:

• What is it: Chondroitin is another essential component of cartilage and a common complement to glucosamine supplements.
• How it helps: Chondroitin is believed to reduce joint pain and inflammation. Then, it potentially slows down the progression of osteoarthritis. If combined with glucosamine, these supplements can provide synergistic benefits.

Chemical Structure of Chondroitin [2]

3. Omega-3 Fatty Acids:

• What are they: Omega-3 fatty acids are polyunsaturated fats commonly found in fish oil supplements.
• How they help: Omega-3 fatty acids possess anti-inflammatory properties. They may also help reduce joint pain and stiffness. They are frequently used to manage conditions like rheumatoid arthritis and other inflammatory joint disorders.

4. Turmeric and Curcumin:

• What are they: Turmeric is a vibrant yellow spice. Curcumin is an active compound in Tumeric with potent anti-inflammatory properties.
• How they help: Curcumin supplements could reduce joint pain and enhance joint function in individuals with osteoarthritis and other inflammatory joint conditions.

5. Methylsulfonylmethane (MSM):

• What is it: Methylsulfonylmethane, often referred to as MSM, is a naturally occurring compound that contains sulfur.
• How it helps: MSM is believed to reduce joint pain and inflammation because sulfur is essential for collagen production and joint health.

6. Boswellia:

• What is it: Boswellia serrata, or Indian frankincense, is an herbal supplement.
• How it helps: It may help manage inflammation and reduce symptoms of osteoarthritis and rheumatoid arthritis. It has been used for centuries in traditional medicine for its potential joint-related benefits.

7. Hyaluronic Acid (HA):

• What is it: Hyaluronic acid is a natural component of synovial fluid. It lubricates and cushions the joints.
• How it helps: HA supplements aim to enhance joint lubrication and reduce pain. It can be beneficial for individuals with conditions like osteoarthritis.

8. Collagen:

• What is it: Collagen is a primary protein found in cartilage and other connective tissues.
• How it helps: Collagen supplements improve joint mobility and potentially reduce pain. They are particularly useful for individuals with osteoarthritis.

9. Vitamin D:

• What is it: Vitamin D is a fat-soluble vitamin that plays a crucial role in bone health.
• How it helps: Adequate levels of vitamin D are essential for bone health. It indirectly contributes to joint health by preventing bone loss and preserving joint function.

10. Calcium:

• What is it: Calcium is a mineral vital for maintaining strong bones.
• How it helps: Calcium should be in combination with vitamin D to prevent the onset or progression of osteoporosis.

It’s important to emphasize that their effectiveness can vary from person to person, and their impact may depend on the underlying cause of joint issues. Therefore, before starting any new supplement regimen, it’s advisable to consult with a healthcare professional. Additionally, maintaining a healthy lifestyle with regular exercise, a balanced diet, and weight management is essential for promoting and preserving joint health in the long term.

Conclusion

Incorporating these substances and supplements can be valuable for your joint health. Yet, always remember that personalized guidance from a healthcare provider is essential as well. Stanford Chemicals Company (SCC) is a trustful supplier of chondroitin sulfate, hyaluronic acid, etc. Customization is also available. Please check our homepage for more information.

Reference:

[1] American Chemistry Society (2020). Molecule of the Week Archive D-Glucosamine. American Chemistry Society. https://www.acs.org/molecule-of-the-week/archive/g/d-glucosamine.html

[2] American Chemistry Society Huskisson, Edward. (2008). Glucosamine and Chondroitin for Osteoarthritis. The Journal of international medical research. 36. 1161-79. 10.1177/147323000803600602.

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The world of skincare is a treasure trove of ingredients that promise healthier, more radiant skin. Among the standout stars in this realm are glycolic acid, lactic acid, and hyaluronic acid. These compounds are not just buzzwords; they are potent components in skincare products, each with unique attributes and benefits. Let’s embark on a journey through the world of skincare acids, understanding their distinct roles, and how they can transform your daily beauty routine.

Skincare: Exfoliation

Glycolic Acid: The Exfoliation Powerhouse

At the forefront of our exploration is glycolic acid, a member of the alpha hydroxy acid (AHA) family. This acid’s claim to fame lies in its exceptional exfoliating properties. Sourced from sugar cane or produced synthetically, glycolic acid breaks down the bonds holding dead skin cells at the skin’s surface. This process accelerates the shedding of these cells, unveiling a smoother, brighter complexion. The visible benefits are manifold, from improved skin texture and tone to the reduction of fine lines, wrinkles, and age spots. This AHA also aids in addressing acne-prone skin by unclogging pores and reducing the risk of breakouts.

Yet, while glycolic acid is a formidable ally in skincare, it demands respect. Its potent exfoliating nature can be harsh on sensitive skin, potentially causing irritation, redness, or peeling when used inappropriately. Following product instructions is vital, especially for beginners.

Lactic Acid: The Gentle Exfoliator and Hydrator

Another member of the AHA family, Lactic acid, deserves its share of the spotlight. Like glycolic acid, it offers gentle exfoliation, but it is known for its milder nature, making it a preferred choice for individuals with sensitive skin. Often sourced from sour milk or synthetically produced, lactic acid works by gently removing dead skin cells, leaving the skin with an improved texture and a healthy glow. One of its unique attributes is its ability to hydrate the skin, making it especially suitable for individuals grappling with dry skin. Lactic acid’s hydrating properties contribute to its gentle nature, resulting in a smoother complexion with fewer signs of hyperpigmentation and an even skin tone.

However, as with any skincare ingredient, excessive use can lead to irritation. To maximize the benefits and minimize the risks, it’s crucial to follow product instructions and exercise caution.

Hyaluronic Acid: Nature’s Hydration Marvel

In the realm of skincare, hyaluronic acid takes on a different role compared to glycolic and lactic acids. Rather than exfoliating, hyaluronic acid is a natural component found within the human body, particularly in the skin, connective tissues, and eyes.

Its superpower lies in its ability to attract and hold a significant amount of water, making it a hydrating dynamo. When applied topically, hyaluronic acid keeps the skin well-hydrated, ensuring it remains plump and youthful in appearance. Its versatility shines as it is suitable for all skin types, including sensitive skin. The hydration it provides is not just for dry skin; it contributes to overall skin health and can reduce the appearance of fine lines and wrinkles, making it a popular choice in anti-aging and moisturizing skincare products. Hyaluronic acid is generally well-tolerated with a low risk of irritation, although in rare cases, it may lead to temporary redness or irritation.

Conclusion

Navigating skincare acids requires considering your skin type and goals. Glycolic acid revitalizes your complexion, unveiling smoother, more radiant skin. Lactic acid provides a gentler yet equally effective exfoliating solution. Hyaluronic acid quenches your skin’s thirst, leaving it plump and youthful.

Adhering to product instructions and introducing these ingredients gradually into your skincare routine helps unlock their transformative potential. With glycolic acid, lactic acid, and hyaluronic acid, you’re equipped for a journey to healthier, more radiant skin.

Stanford Chemicals Company (SCC), a leading USA-based wholesale supplier, specializes in pure organic hyaluronic acid. With expertise in medical, cosmetic, and food-grade hyaluronic acid (HA), our sodium hyaluronate powder is non-animal, vegan, and kosher compliant. If you’re interested, send us an inquiry to discover how we can meet your specific requirements.

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When it comes to achieving radiant, youthful skin, the beauty industry is awash with a myriad of products and ingredients. Amidst the sea of options, two key players have emerged as powerhouses in the skincare world: Vitamin C and Hyaluronic Acid. These two ingredients, when combined, create a dynamic duo that can transform your complexion, leaving you with a radiant and hydrated glow. This article is going to explore their benefits and applications. Hope that you can have a better understanding.

The Role of Vitamin C: Shielding Your Skin

Let’s start by learning about vitamin C. It is also known as ascorbic acid and is a potent antioxidant found naturally in various fruits and vegetables. While it’s an essential nutrient for overall health, its benefits for the skin are equally impressive. Here’s how Vitamin C works its magic:

Vitamin C Abundant Food

1. Neutralizing Free Radicals: The primary role of vitamin C is to neutralize free radicals, unstable molecules that can damage skin cells through a process called oxidative stress. By reducing free radical damage, vitamin C helps prevent premature aging, including fine lines, wrinkles, and age spots.
2. Boosting Collagen Production: Vitamin C plays a pivotal role in collagen synthesis as well. Collagen, a vital protein, plays a key role in maintaining skin’s firmness and youthful appearance. However, as we grow older, the natural production of collagen diminishes, resulting in skin sagging. Vitamin C stimulates collagen production, aiding in skin firmness and elasticity.
3. Brightening the Skin: It has the ability to inhibit melanin production, making it an effective skin brightener. It can help fade dark spots, pigmentation, and even out skin tone, leaving your complexion looking more radiant.

The Magic of Hyaluronic Acid: Skin’s Hydration Hero

On the other side of the spectrum, we have hyaluronic acid, a naturally occurring substance in the skin. Its primary role is to maintain moisture levels. Here’s why hyaluronic acid is crucial for skin health:

Hyaluronic Acid for Hydration

1. Intense Hydration: Hyaluronic acid has an incredible ability to retain water. It possesses the remarkable ability to retain up to 1,000 times its weight in water, making it an outstanding hydrating agent. When applied topically, it attracts and binds moisture to the skin, keeping it plump and well-hydrated.
2. Smoothing Fine Lines: Dehydrated skin often accentuates fine lines and wrinkles. By keeping the skin adequately moisturized, HA helps diminish the appearance of these age-related concerns.
3. Enhancing Skin Barrier: A well-hydrated skin barrier is essential for preventing moisture loss and protecting against external aggressors. HA fortifies the skin’s barrier, making it more resilient.

The Power of Combining Vitamin C and Hyaluronic Acid

Now, imagine the benefits of Vitamin C and hyaluronic acid working together in your skincare routine. It’s a perfect pairing in the world of skincare. Their synergy can transform your skin.

1. Enhanced Antioxidant Protection: Vitamin C and hyaluronic acid together create a shield against environmental stressors. While the former fights free radicals, the latter locks in moisture, preventing skin from drying out due to external aggressors.
2. Intense Hydration with Brightening Effect: HA ensures that your skin stays optimally hydrated, enhancing the effectiveness of VC in brightening the complexion. Together, they reduce the appearance of dullness and uneven skin tone.
3. Youthful, Plump Skin: Vitamin C’s collagen-boosting properties complement hyaluronic acid’s ability to keep the skin plump and dewy. This combination results in a more youthful-looking complexion with improved firmness.

Studies and Researches Supporting Vitamin C and Hyaluronic Acid

All these advantages have been supported, including antioxidant protection, collagen production, wrinkle reduction, and skin hydration. Here are some studies and research findings that support the use of vitamin C and hyaluronic acid in skincare:

1. Antioxidant Benefits of Vitamin C:

A study published in the Journal of Clinical and Aesthetic Dermatology (2017) found that topical application of vitamin C can help protect the skin against UV-induced damage and photodamage. It acts as an antioxidant and reduces the formation of free radicals. [1]

2. Collagen Production and Wrinkle Reduction:

Research published in the Journal of Investigative Dermatology (2001) demonstrated that vitamin C plays a crucial role in collagen synthesis. Collagen is essential for maintaining skin elasticity and reducing the appearance of wrinkles. [2]

3. Skin Hydration with Hyaluronic Acid:

A study in the Journal of Clinical and Aesthetic Dermatology (2014) highlighted the ability of hyaluronic acid to retain water and provide substantial skin hydration, leading to improved skin texture and reduced dryness. [3]

4. Combined Benefits:

A study in the Dermatologic Surgery journal (2005) showed that combining vitamin C and hyaluronic acid in a skincare regimen can enhance overall skin quality, including improvements in skin hydration, firmness, and the reduction of fine lines and wrinkles. [4]

However, it’s important to note that individual results may vary, and consistent use of these ingredients in a skincare routine is typically required to see significant improvements in the skin. Please seek guidance from a dermatologist or skincare professional for personalized recommendations.

Conclusion

In the realm of skincare, the partnership between Vitamin C and Hyaluronic Acid is a true game-changer. Their individual prowess in protecting, hydrating, and rejuvenating the skin is impressive, but when combined, they create a harmonious symphony of benefits. With Vitamin C’s potent antioxidant protection and collagen-boosting abilities, coupled with Hyaluronic Acid’s exceptional hydration prowess, your skin is in for a treat. Stanford Chemicals Company (SCC) is a reliable hyaluronic acid supplier of medical grade, cosmetic grade, and food grade hyaluronic acid. Send us an inquiry if you are interested.

Reference:

[1] Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017 Jul;10(7):14-17. Epub 2017 Jul 1. PMID: 29104718; PMCID: PMC5605218.

[2] Betty V. Nusgens, Alain C. Colige, Charles A. Lambert, Charles M. Lapière, Philippe Humbert, André Rougier, Marek Haftek, Alain Richard, Pierre Creidi, Topically Applied Vitamin C Enhances the mRNA Level of Collagens I and III, Their Processing Enzymes and Tissue Inhibitor of Matrix Metalloproteinase 1 in the Human Dermis11Part of this work was presented in poster form at the American Academy of Dermatology, San Francisco, CA, March 10–15, 2000., Journal of Investigative Dermatology, Volume 116, Issue 6, 2001, https://doi.org/10.1046/j.0022-202x.2001.01362.x.

[3] Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014 Mar;7(3):27-9. PMID: 24688623; PMCID: PMC3970829.

[4] Farris PK. 2005, ‘Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions.’ Dermatologic Surgery, vol 31 no. 7 pt2 pp. 814–818

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Hyaluronic acid (HA) has gained significant attention in the beauty industry for its remarkable hydrating and anti-aging properties. It has become a staple ingredient in skincare products, known for its ability to plump and moisturize the skin. However, the benefits of HA extend far beyond the realm of beauty. This versatile substance also plays a vital role in joint health and overall well-being. Let’s dive into the versatility of hyaluronic acid and discover its diverse applications.

Understanding Hyaluronic Acid

Hyaluronic acid is a type of carbohydrate molecule that is naturally produced by the body. It is found in various tissues and fluids, such as the skin, joints, and eyes. HA is known for its ability to retain moisture, which helps to keep tissues well-lubricated and moisturized. It has various applications in the medical, cosmetic, and pharmaceutical industries.

Chemical Structure of HA

Applications of Hyaluronic Acid

1.    The Beauty of Hyaluronic Acid

In the realm of beauty, hyaluronic acid has gained a reputation as a holy grail ingredient. Its unique ability to retain moisture makes it a powerful hydrator for the skin. HA molecules can hold up to 1,000 times their weight in water, helping to replenish and maintain optimal hydration levels. By attracting and locking in moisture, it plumps the skin, smooths out fine lines and wrinkles, and enhances overall radiance. Therefore, HA becomes a key ingredient in serums, moisturizers, and facial masks, providing a boost of hydration and promoting a youthful complexion.

2.    Dermal Fillers and Facial Contouring

Hyaluronic acid dermal fillers are another HA product in the field of cosmetics. They are used to restore lost volume, enhance facial contours, and diminish the appearance of wrinkles and folds. By injecting them beneath the skin’s surface, a skilled professional can sculpt and rejuvenate the face, providing natural-looking results. Dermal fillers offer a non-surgical solution for those seeking facial rejuvenation and enhancement. So, most individuals can resume their regular activities immediately after the treatment.

3.    Joint Health and Hyaluronic Acid

Beyond its beauty benefits, hyaluronic acid plays a critical role in maintaining healthy joints. It is naturally present in the synovial fluid that lubricates and cushions the joints. HA acts as a shock absorber, reducing friction and ensuring smooth movement. With age or certain medical conditions, its production in the joints may decrease, leading to joint stiffness, discomfort, and limited mobility. In these cases, HA injections can be administered directly into the affected joint to restore lubrication, reduce pain, and improve joint function. These injections have become a popular treatment option for individuals with conditions such as osteoarthritis.

4.    Eye Health and Lubrication

Medical-grade HA is also used in ophthalmology for its lubricating properties in the form of eye drops. These eye drops help alleviate symptoms of dry eyes by providing a protective and moisturizing layer on the surface of the eyes. The hyaluronic acid forms a barrier that prevents moisture loss, reduces friction, and soothes dryness, thereby improving overall eye comfort and health.

5.    Wound Healing and Tissue Repair

Hyaluronic acid’s versatile nature extends to the realm of wound healing and tissue repair. HA plays a crucial role in the body’s natural healing processes. It promotes cell migration, collagen synthesis, and angiogenesis (the formation of new blood vessels), which are essential for efficient wound healing. By providing a favorable environment for tissue regeneration, this natural substance supports the body’s ability to heal wounds, reduce scarring, and promote overall tissue repair.

Conclusion

Hyaluronic acid is undoubtedly a versatile and multi-faceted compound. Its hydrating and anti-aging properties make it a go-to ingredient in the beauty industry, helping individuals achieve plump and youthful skin. Moreover, this acid plays a vital role in joint health, wound healing, eye lubrication, and facial contouring. Its ability to provide hydration, lubrication, and tissue repair makes it a valuable asset in various medical and cosmetic applications. Whether you’re seeking a beauty boost or joint relief, hyaluronic acid proves to be an exceptional ally in promoting overall well-being.

Stanford Chemicals Company (SCC) offers quality hyaluronic acid powder for skin care and joint health applications. Both cosmetic-grade HA and medical-grade HA are available. You can check our website for more information. Hope that you can find the perfect HA products for your business or research.

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Dry eyes can be a bothersome and uncomfortable condition that affects many people. Whether caused by environmental factors, aging, or underlying health conditions, finding relief for dry eyes is essential for maintaining eye health and comfort. While eye drops and other treatments are commonly used, there’s a powerful ingredient that has emerged as the ultimate moisturizer for dry eyes: hyaluronic acid (HA). Let’s explore how hyaluronic acid can provide much-needed hydration and relief for dry eyes.

Human Eyes

What Is Dry Eye Syndrome?

Dry eye syndrome occurs when there is insufficient moisture or lubrication on the surface of the eyes, which can lead to symptoms such as itching, burning, redness, and a gritty sensation. Dry eyes can be caused by various factors, including decreased tear production, excessive tear evaporation, or an imbalance in the composition of tears. It’s a condition that can significantly impact daily life and overall eye health.

Dry Eye Syndrome [1]

How Hyaluronic Acid Is Used to Relieve Dry Eyes?

Hyaluronic acid is a natural humectant that alleviates dry eye syndrome in the following ways.

–The Hydrating Power of Hyaluronic Acid

Hyaluronic acid is a natural substance in the body with a remarkable ability to retain moisture. It can hold up to 1,000 times its weight in water, making it an exceptional hydrating agent. When applied topically to the eyes, HA forms a protective barrier on the surface of the eyes, preventing moisture loss and promoting hydration. This helps to alleviate dryness and discomfort, providing relief to individuals suffering from dry eyes.

–Restoring Tear Film Balance

The tear film is a thin layer that covers the surface of the eyes, keeping them moisturized and protected. In individuals with dry eyes, there is often an imbalance in the tear film composition, resulting in inadequate lubrication. HA helps restore this balance by enhancing the quality and quantity of tears. It promotes the production of high-quality tears that effectively coat the eyes, reducing friction and soothing dryness.

–Soothing and Calming Irritation

Dry eyes often come with symptoms of irritation, such as redness, itching, and a burning sensation. Hyaluronic acid has soothing and anti-inflammatory properties that can help alleviate these discomforts. By moisturizing the eyes and reducing inflammation, HA provides relief and helps calm irritated eyes. Its gentle and non-irritating nature makes it suitable for those with sensitive eyes.

–Easy Application and Compatibility

Using hyaluronic acid for dry eyes is simple and convenient. It is available in various forms, including eye drops, gels, and ointments. Eye drops containing hyaluronic acid can be applied directly to the eyes for quick relief. These formulations are compatible with contact lenses, allowing individuals to experience the benefits of hyaluronic acid while wearing their lenses. Whether you’re at home, at work, or on the go, hyaluronic acid eye drops can be easily incorporated into your daily routine.

Related reading: How to Choose Eye Drops?

–Long-Lasting Hydration

One of the significant advantages of hyaluronic acid for dry eyes is its long-lasting hydration. Unlike traditional eye drops that provide temporary relief, hyaluronic acid creates a reservoir of moisture that gradually releases over time. This means that the eyes stay hydrated for longer periods, reducing the need for frequent reapplication and providing sustained comfort throughout the day.

Conclusion

In a word, hyaluronic acid is a game-changer when it comes to moisturizing dry eyes. Its hydrating properties, ability to restore tear film balance, and soothing effects make it the ultimate moisturizer for dry eyes. If you’re experiencing the discomfort of dry eyes, consult with an eye care professional to determine if hyaluronic acid eye drops or other formulations may be suitable for your needs. Embrace the power of hyaluronic acid and enjoy the relief and comfort of well-hydrated eyes.

Stanford Chemicals Company (SCC) is a reliable supplier of hyaluronic acid of different grades and molecular weights. For more information, check our homepage.

Reference:

[1] Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP. Tear Metabolomics in Dry Eye Disease: A Review. International Journal of Molecular Sciences. 2019; 20(15):3755. https://doi.org/10.3390/ijms20153755

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