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What Does Sodium Hyaluronate Do For The Skin

Hyaluronic acid, a direct chain macromolecule acidic polysaccharide formed by D- glucuronic acid (GlcA) and N- acetyl glucosamine (GlcNAc) connected by a double sugar unit alternately. Commodity HA is usually its sodium salt, sodium hyaluronate.

 

Sodium hyaluronate is widely distributed in the body, with higher content in articular cavity, skin, eyes, vitreous body, cartilage, umbilical cord and cock crown. A large number of studies have found that sodium hyaluronate has many physiological functions, such as regulating cell adhesion, localization, differentiation, promoting cell proliferation and migration, and participating in biological processes such as moisturizing, lubrication, wound healing, tissue repair and regeneration, inflammatory reaction, embryo development and tumor.

Sodium hyaluronate is a major component of intercellular and extracellular matrix, which maintains normal structure and function of cells. Sodium hyaluronate can combine with its weight of 1000 times the weight of water, its water retention performance is positively related to its concentration and molecular weight. It is widely used as a natural moisturizer in the cosmetic industry. HA is the main component of synovial fluid in organism's joint cavity, and its good viscoelasticity and lubricity can reduce the time of body movement. The pressure and wear of the nodes; the clots of sodium hyaluronate and fibrin can play a structural function during the healing process, which can promote the phagocytosis of the granulocytes and regulate the inflammatory reaction, while the low molecular weight sodium hyaluronate produced locally can promote angiogenesis; we have now known that sodium hyaluronate has a protective effect. Cells affect cell migration, proliferation and differentiation, and affect cell phagocytosis.

 

Sodium hyaluronate, as a natural component of organism, is only 15 g in normal human body, but it plays a great role in maintaining normal function and delaying senility. The content of HA in human embryos is the highest in the embryonic period, and decreases with age. If the relative content of HA in human body is 100% when it is 20 years old, it will decrease to 65%, 45% and 25% at 30, 50 and 60, respectively. The content of HA in the same age group is also different. The HA content in the body of the elderly with premature aging is significantly reduced, showing many symptoms of aging. The reduction of HA can lead to arthritis, skin aging, increased wrinkles, and many problems such as eyes and old flowers. Therefore, the content of sodium hyaluronate in the body can be regarded as a ruler of the degree of human aging. Currently, oral sodium hyaluronate supplementation of endogenous hyaluronic acid is considered an effective way to improve health and prolong life.

 

At the end of 1980s, oral sodium hyaluronate beauty and health food appeared in Japan. The theoretical basis is that sodium hyaluronate, after oral digestion and absorption, increases the precursor of hyaluronic acid synthesis in the body, increases the content of hyaluronic acid in the body and focuses on the skin tissue, and then strengthens the water retention ability of the skin, softens the skin cuticle, and improves the efficacy of skin elasticity and wrinkles. Sodium hyaluronate contains only local moisturizing effect on the skin surface, while oral sodium hyaluronate can increase the content of endogenous hyaluronic acid through the degradation, absorption and resynthesis of exogenous hyaluronic acid, and activate the whole body cells to play the overall function of beauty and health care.