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Hyaluronic Acid

Hyaluronic AcidProduct Name: Hyaluronic Acid
Synonyms: Hyaluronic Acid, Sodium hyaluronate Hyaluronan
CAS: 9067-32-7
MF: (C14H22NNaO11)n
Appearance: White powder
Standard: EP7.0
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Introduce

 
Hyaluronan (also called hyaluronic acid or hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Hyaluronan is a polymer of disaccharides, themselves composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. It can be obtained by extracting from cockscomb or through microorganism fermentation.
 

Application

 
Food supplements:
Hyaluronan through the oral administration after the digestion absorption, increases in vivo hyaluronan synthesis the precursor, causes in the skin and other organizations hyaluronan resultant quantity increases, thus enables the skin the water retention property to increase, rich elasticity, wrinkle reduction.
Medical applications:
Hyaluronan could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment.
Hyaluronan can also be used to treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.
Hyaluronan has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the hyaluronan to facilitate cell migration into the wound.
Hyaluronan is also used in anti-adhesive products, which are widely used in pelvic and abdominal surgery to prevent postoperative adhesions.
Cosmetics applications:
Hyaluronan has outstanding moisture keeping ability, thus called Natural Moisturing Factor in the world. Hyaluronan is a common ingredient in skin-care products, which can be used as a very effective topical humectant.
In 2003, the FDA approved hyaluronan injections for filling soft tissue defects, which can be used for facial wrinkles, lip augmentation, reduction of folds and wrinkles, and removal of scars.
Equine applications:
Hyaluronan is used in treatment of articular disorders in horses, in particular those in competition or heavy work. It is indicated for carpal and fetlock joint dysfunctions, especially used for synovitis associated with equine osteoarthritis. It can be injected directly into an affected joint, or intravenously for less localized disorders. It may cause mild heating of the joint if directly injected, but this does not affect the clinical outcome. Intra-articularly administered medicine is fully metabolized in less than a week.

 

Fermented Product

Grade

MOQ

US$

Inquiry

Food grade

5kg

$500/kg

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Cosmetics grade

5kg

$560/kg

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Eye drops grade

1kg

$2800/kg

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Injection grade

100g

$25000/kg

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Items

Specifications

Appearance

White powder

Infrared absorption spectrophotometry

Ph. Eur. Reference Standards

Appearance of solution

A600nm≤0.01

pH (5mg/mL solution)

5.0-8.0

Intrinsic viscosity

Measured values

Molecular weight

Measured values

Sulfated glycosaminoglycans

≤1%

Nucleic acid

A260nm≤0.5

Protein

≤0.1%

Chlorides

≤0.5%

Iron

≤80ppm

Heavy metals

≤20ppm

Loss on drying

≤20.0%

Bacterial counts

≤100cfu/g

Mold and Yeast

≤100cfu/g

Sodium hyaluronate

95%-105%

Glucuronic acid

≥42.0%