Best Companions of Hyaluronic Acid for Skincare


Skincare ingredients complement each other and elevate the effectiveness. Although hyaluronic acid (HA) is known for its exceptional hydration, it turns more powerful in the company of several potent allies.

Skincare Products

Here, this article is going to discuss these best companions. Hope that you can learn more about moisture-retaining glycerin, barrier-boosting ceramides, collagen-stimulating peptides, and most importantly, the hydrating hyaluronic acid.

Best Companions of Hyaluronic Acid: Glycerin, Ceramides, and Peptides

Let’s first start with several “besties” that work exceptionally well together with hyaluronic acid. Here are some of HA’s skincare best companions:

  1. Glycerin—Humectant and Emollient: Glycerin is also called glycerol. It is a colorless, odorless, and syrupy liquid with various functions in skincare and cosmetics. First, it is known for its humectant properties. Namely, glycerin attracts and retains water for the skin. Additionally, thanks to its emollient nature, it softens and smooths the skin’s surface. Therefore, it has become a versatile ingredient in skincare formulations.
  2. Ceramides—Skin Barrier: Ceramides are lipid molecules found naturally in the skin’s outermost layer, the stratum corneum. They play a crucial role in maintaining the skin barrier. They help to retain moisture, regulate hydration, and protect against environmental aggressors. Such a skin barrier function contributes to skin resilience, suppleness, and overall skin health.
  3. Peptides for Skin Firmness: Peptides are short chains of amino acids, the building blocks of proteins. They play essential roles in various biological functions. In skincare, peptides are used for their ability to signal cells to perform specific tasks, such as producing collagen. These small protein fragments can target various skincare concerns like fine lines, wrinkles, and skin texture. In these ways, peptides enhance skin firmness and elasticity.

Best Companions of Hyaluronic Acid: Versatile Vitamins

Alongside these allies, a variety of vitamins and acids join forces to tackle skincare concerns.

  1. Anti-Aging Retinol: Retinol is a derivative of vitamin A. This powerful ingredient is celebrated for its anti-aging properties. It aids in skin cell turnover, and promotes the emergence of newer, healthier cells while diminishing the appearance of fine lines, wrinkles, and uneven skin tone. It stimulates collagen production as well. However, it can cause skin sensitivity and increased sun sensitivity. So, diligent use of sunscreen is recommended.
  2. Tretinoin—Acne Treatment: Tretinoin is another derivative of vitamin A. Tretinoin needs a prescription, while retinol is a milder over-the-counter derivative. It functions as a retinoid. That is to say, it can stimulate skin cell turnover, improve skin texture, and mitigate signs of aging. Despite its effectiveness, it has the potential to cause skin sensitivity and sun sensitivity. Consult a dermatologist for guidance on proper application, please.
  3. Niacinamide—A Versatile Vitamin: Niacinamide is also known as vitamin B3. This versatile skincare ingredient has numerous benefits. It helps strengthen the skin barrier. With anti-inflammatory properties, it soothes irritated or sensitive skin, minimizes redness, and regulates oil production. Also, it aids in reducing the appearance of enlarged pores.
  4. Vitamin B5–Soother and Moisture Skin: Vitamin B5 or pantothenic acid is a water-soluble vitamin. It serves as a natural humectant, promotes hydration, and supports the skin barrier. It is also valued for its ability to soothe and nourish the skin.
  5. Vitamin C—Brightener Skin: Vitamin C, or ascorbic acid, is a potent antioxidant for skin health. It helps protect the skin from free radical damage caused by UV exposure, pollution, and other environmental stressors. With notable brightening properties, it promotes a more even skin tone and reduces the appearance of dark spots. It aids in collagen synthesis as well.
  6. Vitamin E—A Powerful Antioxidant: Vitamin E is a fat-soluble antioxidant. It shields the skin from oxidative stress and helps to combat signs of premature aging. It also supports skin repair and acts as a moisturizer. It can reduce inflammation as well.

Related reading: 3 Types of Promising Skincare Ingredients: Bamboo Extract, Vitamin B5, and Sodium Hyaluronate

Best Companions of Hyaluronic Acid: Various Acids

  1. Alpha Hydroxy Acids (AHAs)–Exfoliation: AHAs are water-soluble acids derived from fruits, milk, or plants. For example, glycolic acid comes from sugar cane, while lactic acid is from milk. These acids remove dead skin cells and promote cell turnover. Thus, AHAs help improve skin texture, reduce the appearance of fine lines, wrinkles, and hyperpigmentation, and enhance overall skin radiance.
  2. Beta Hydroxy Acids (BHAs) and Exfoliation: BHAs, such as salicylic acid, are oil-soluble acids. These acids address skin concerns at a deeper level. BHAs effectively exfoliate the skin’s surface and deep within pores, so they are beneficial for treating acne-prone or oily skin. Salicylic acid is the most common BHA. It helps unclog pores, reduce inflammation, and break down excess oil.
  3. Azelaic Acid for Acne and Dark Spots: This acid is a skincare ingredient with multifunctional properties. It helps treat acne by reducing inflammation and eliminating bacteria. Besides, azelaic acid is effective in reducing hyperpigmentation, evening out skin tone, and minimizing the appearance of dark spots or melasma. It’s also recognized for its gentle exfoliating effects.
  4. Ferulic Acid–A Potent Antioxidant: It is found in various plant-based sources. In skincare, it can enhance the stability and effectiveness of other antioxidants like vitamins C and E. In addition, it aids in skin cell regeneration and has anti-inflammatory properties.

Related reading: The Secrets of Skincare: Glycolic Acid, Lactic Acid, and Hyaluronic Acid

Best Companions of Hyaluronic Acid: Quality Products

There are many more skincare besties that pair well with hyaluronic acid. All of them can lead to a tailored skincare routine catering to hydration, protection, and overall skin well-being (See Table 1). Nevertheless, it’s essential to patch-test new products and put them gradually into your routine to ensure compatibility and effectiveness.


Stanford Chemicals Company (SCC) offers quality hyaluronic acid powder for skincare. Different grades and molecular weights are available. Please visit our website for the perfect HA products for your business or research.


Table 1 Best Companions of Hyaluronic Acid

Substance Other Name Functions
Glycerin Glycerol Humectant and Emollient
Ceramides Skin Barrier
Peptides Short Chains Of Amino Acids Skin Firmness
Retinol Derivative of Vitamin A Anti-Aging
Tretinoin Derivative of Vitamin A Acne Treatment
Niacinamide Vitamin B3 Versatility
Vitamin B5 Pantothenic Acid Soother and Moisture Skin
Vitamin C Ascorbic Acid Brightener Skin
Vitamin E A Powerful Antioxidant
Alpha Hydroxy Acids (AHAs) Glycolic Acid & Lactic Acid Exfoliation
Beta Hydroxy Acids (BHAs) Salicylic Acid Exfoliation
Azelaic Acid For Acne and Dark Spots
Ferulic Acid A Potent Antioxidant


November 24, 2023 Herbal Extracts, Hyaluronic Acid, Skin Care , , , , ,
About Cathy

Cathy Leenerts graduated from Ohio State University majoring in applied chemistry. She has been writing about various materials for three years at Stanford Advanced Materials (SAM). She is committed to providing brief and accurate articles for readers. Comments and emails are welcome.

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