Celastrol Description

Celastrol is an effective proteasome inhibitor that induces apoptosis in cancer cells by inhibiting proteasome activity. It has a strong anti-oxidation effect, anti-rheumatic action, and spermicidal action. It is a naturally active product that is currently worthy of attention. Its superior anti-obesity function has also been discovered in recent years.

Celastrol Specifications

Product Name	Celastrol
CAS Registry Number	34157-83-0
Molecular Formula	C29H38O4
Molecular Weight	450.61
Purity	≥98%  HPLC
Appearance	Red powder
Package	1kg-25kg
Shelf life	24 months
Functions	anti-rheumatic, anti-oxidation, anti-obesity

Celastrol Benefits

• Anti-Inflammatory Properties: Celastrol has powerful anti-inflammatory effects, which can help reduce symptoms of inflammatory diseases such as rheumatoid arthritis and psoriasis by inhibiting pro-inflammatory pathways and reducing cytokine production.
• Immunomodulatory Effects: Celastrol helps regulate the immune system, making it beneficial for autoimmune diseases like systemic lupus erythematosus and multiple sclerosis. It reduces the risk of tissue damage by preventing immune overactivity.
• Anticancer Potential: Studies have shown that Celastrol can inhibit the growth of various cancer cells, including those in liver, breast, prostate, and lung cancers. It induces apoptosis (programmed cell death) and disrupts cancer cell proliferation.
• Weight Loss and Metabolic Regulation: Celastrol may aid in weight loss by influencing appetite regulation and energy metabolism. It has shown promise in improving insulin sensitivity and lowering blood glucose levels, which can be beneficial for metabolic syndrome patients.
• Neuroprotective Benefits: Celastrol offers neuroprotection and has potential therapeutic effects on neurodegenerative diseases such as Alzheimer's and Parkinson's. It reduces neuroinflammation and protects neurons from damage.
• Antioxidant Properties: As an antioxidant, Celastrol neutralizes free radicals and reduces oxidative stress, thereby protecting cells from damage and slowing the aging process. It helps maintain cellular health.
• Cardiovascular Health: Celastrol may help lower blood pressure and improve cardiovascular health by reducing inflammation and oxidative stress. It can also prevent atherosclerosis, thus supporting heart health.

Celastrol Applications

• Rheumatic Disease and Cancer Treatment: It's utilized for its anti-inflammatory and anticancer properties, offering potential therapeutic benefits in managing rheumatic diseases and various cancers.
• Medical Research: Employed extensively in studies to explore its mechanism of action and potential in treating other conditions, including obesity and neurodegenerative diseases.

Precautions

Triprolactone may have certain toxicity and side effects, especially in high doses, so it needs to be used under the guidance of a doctor.

Celastrol Packaging

5 g, 10 g, 50 g, 100 g/ bottle, or as required.
Our Celastrol is clearly tagged and labeled externally to ensure efficient identification and quality control. Great care is taken to avoid any damage which might be caused during storage or transportation.

Reference

1. Pfuhlmann K, et.al. Celastrol-induced weight loss is driven by hypophagia and independent from UCP1, Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146.
2. Corson TW, Crews CM. Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials. Cell. 2007 Sep 7;130(5):769-74.