|Keywords||Osteoporosis, cancer, breast cancer, colon cancer, prostatic cancer|
Specifications of Formononetin
|CAS Registry Number||485-72-3|
|Shelf life||2 years|
|Functions||Prevent cancer, relieve osteoporosis|
Description of Formononetin
Formononetin is an O-methylated isoflavone that can be found in many herbs such as red clover. It is usually used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. It promotes endothelial repair and wound healing in a process involving the over-expression of Egr-1 transcription factor through the regulation of the ERK1/2 and p38 MAPK pathways.
Formononetin, present in soybean, Astragalus membranaceus, Pycnanthus angolensis, Sophora flavescens, and Trifolium pratense, has shown anti-inflammatory, anticancer, and antioxidant effects.
Applications of Formononetin
- Laboratory research
- Ingredient of drugs
- Medjakovic, S.; Jungbauer, A. (2008). “Red Clover Isoflavones Biochanin A and Formononetin are Potent Ligands of the Human Aryl Hydrocarbon Receptor”. The Journal of Steroid Biochemistry and Molecular Biology. 108 (1–2): 171–177.
- Li, Shang; Dang, Yuanye; Zhou, Xuelin; Huang, Bin; Huang, Xiaohui; Zhang, Zherui; Kwan, Yiu Wa; Chan, Shun Wan; Leung, George Pak Heng; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man (2015). “Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway”. Scientific Reports. 5: 16815.
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