050-000-364 Tetrandrine (CAS: 518-34-3)

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Product Name Tetrandrine
CAS No. 518-34-3
Appearance White powder
Type Alkaloid
Source Stephania Tetrandra Root
Keywords Tetrandrine
Related products Medical Grade Sodium Hyaluronate, Chondroitin Sulfate, Dihydromyricetin, Herbal Extract
Synonyms (1)-6,6’,7,12-Tetramethoxy-2,2’-dimethylberbaman
Description

Description

Tetrandrine (CAS: 518-34-3) Description

Tetrandrine (CAS: 518-34-3), a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic, and antiallergenic effects. It inhibits the degranulation of mast cells. It has a quinidine-like anti-arrhythmic effect. It is isolated from the plant Stephania tetrandra, and other Chinese and Japanese herbs.

Tetrandrine (CAS: 518-34-3) Specifications

Product Name Tetrandrine
CAS Registry Number 518-34-3
Molecular Formula C38H42N2O6
Molecular Weight 622.75
Assay ≥90%
Pubchem 73078

Tetrandrine (CAS: 518-34-3) Applications:

Stephania tetrandra and other related species of Menispermaceae from the major source of the bisbenzylisoquinoline alkaloid – Tetrandrine. The plant is extensively referenced in the Chinese Pharmacopoeia for its use in the Chinese medicinal system as an analgesic and diuretic agent and also in the treatment of hypertension and various other ailments, including asthma, tuberculosis, dysentery, hyperglycemia, malaria, cancer, and fever. Tetrandrine, well-known to act as a calcium channel blocker, has been tested in clinical trials and found effective against silicosis, hypertension, inflammation, and lung cancer without any toxicity. Recently, the efficacy of tetrandrine was tested against Mycobacterium tuberculosis, Candida albicans, Plasmodium falciparum, and Ebola virus. Tetrandrine’s pharmacological property has been proved to be through its action on different signaling pathways like reactive oxygen species, enhanced autophagic flux, a reversal of multidrug resistance, caspase pathway, cell cycle arrest, and by modification of calcium channels.[1]

 

Reference

N.Bhagya, K.R.Chandrashekar: Tetrandrine – A molecule of wide bioactivity. https://doi.org/10.1016/j.phytochem.2016.02.005

[1] N.Bhagya, K.R.Chandrashekar: Tetrandrine – A molecule of wide bioactivity. https://doi.org/10.1016/j.phytochem.2016.02.005