|Source||Illicium verum Hook.f.|
|Key words||aromatic biosynthetic pathway, anti-inflammation|
|Related products||Glabridin, Pyrroloquinoline Quinone, Celastrol|
Specifications of Shikimic Acid
|Product Name||Shikimic Acid|
|CAS Registry Number||138-59-0|
|Molecular Weight||174.15 g/mol|
|Shelf life||2 years|
|Functions||Induces remyelination, anti-inflammation, relieve pain|
Description of Shikimic Acid
Shikimic acid is a cyclohexenecarboxylic acid originally isolated from I. religiosum. It decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes when used at a concentration of 80 µM, as well as increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes when used at 40 µM.
Shikimic acid, obtained from star anise present in its anionic form shikimate, is a cyclohexanecarboxylic acid, a cyclohexene, and a cyclitol. The shikimic acid pathway is essentially used to synthesize basic amino acids by plants and lower organisms such as bacteria, fungi, and algae.
Applications of Shikimic Acid
Its naturally occurring form is a major biosynthetic precursor of phenylalanine, tyrosine, and tryptophan and hence of the majority of plant alkaloids. It is also involved in the biosynthesis of lignin, flavonoids, and other important aromatic compounds.
- Bohm, B.A. Shikimic Acid (3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic Acid). Chem. Rev. 65(4), 435-466 (1965).
- Rawat, G., Tripathi, P., and Saxena, R.K. Expanding horizons of shikimic acid. Recent progresses in production and its endless frontiers in application and market trends. Appl. Microbiol. Biotechnol. 97(10), 4277-4287 (2013).
- Kim, M.J., Sim, D.Y., Lee, H.M., et al. Hypolipogenic effect of shikimic acid via inhibition of MID1IP1 and phosphorylation of AMPK/ACC. Int. J. Mol. Sci. 20(3), E582 (2019).
- Lu, F., Yin, D., Pu, Y., et al. Shikimic acid promotes oligodendrocyte precursor cell differentiation and accelerates remyelination in mice. Neurosci. Bull. 35(3), 434-446 (2019 ).