050-000-281 Swertiamarin, CAS 17388-39-5

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Source Swertia L.
Key words Diabetes, β cell, analgesia
Related products Alfa-Lipoic Acid, Biotin, β-Nicotinamide mononucleotide, Metformin (Hydrochloride)


Description of Swertiamarin

Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties. Swertiamarin (50 μg/ml) inhibits nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaws.

Swertiamarin (25 μg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells. It decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day. Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin.

Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic, and hypolipidemic activities.


Specifications of Swertiamarin

Product Name Swertiamarin
CAS Registry Number 17388-39-5
Molecular Formula C16H22O10
Molecular Weight 374.3 g/mol
Purity 10-95 %
Appearance Pale yellow powder
Package 1kg-25kg
Shelf life 2 years
Functions anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity, enhances β cell regeneration

Applications of Swertiamarin

– Laboratory Research:
Swertiamarin has become a subject of interest in laboratory research owing to its diverse biological activities. Studies focus on its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties. For instance, at a concentration of 50 μg/ml, Swertiamarin has exhibited the ability to inhibit nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaws. This highlights its potential role in modulating inflammatory responses.

– Raw Materials for Hair Regeneration Products:
Beyond the laboratory, Swertiamarin contributes to the field of cosmeceuticals as raw material for hair regeneration products. Its inclusion in formulations for hair care is attributed to its purported benefits. Researchers explore its potential to stimulate hair growth, strengthen follicles, and contribute to overall hair health. As a key component in hair regeneration products, Swertiamarin represents a promising avenue in addressing various aspects of hair care and restoration.


  1. Vaijanathappa, J., and Badami, S. Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. Planta Med. 75(1), 12-17 (2009).
  2. Saravanan, S., Islam, V.I., Thirugnanasambantham, K., et al. Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes. Inflamm. Res. 63(6), 451-462 (2014).
  3. Sonawane, R.D., Vishwakarma, S.L., Lakshmi, S., et al. Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol. Cell Biochem. 340(1-2), 1-6 (2010).
  4. Patel, T.P., Rawal, K., Soni, S., et al. Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. Biomed. Pharmacother. 83, 785-791 (2016).
  5. Yang, Y., Li, J., Wei, C., et al. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine 59, 152782 (2019).