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040-000-535 1,2,3-tri-O-acetyl-5-deoxy ribofuranose

1,2,3-tri-O-acetyl-5-deoxy ribofuranose, capecitabine
SKU: 040-000-535 Category:
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Type Active Pharmaceutical ingredient
CAS No. 62211-93-2
Chemical Formula C11H16O7
Appearance yellow powder
Packaging 1g, 5g, 10g, 25g, 100g, 500g
Assay ≥98%
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Description

Description

1,2,3-tri-O-acetyl-5-deoxy ribofuranose Introduction

1,2,3-tri-O-acetyl-5-deoxy ribofuranose is used to synthesize anticancer drugs such as capecitabine and fluoride. It is an important intermediate in the synthesis of capecitabine.

1,2,3-tri-O-acetyl-5-deoxy ribofuranose Specification

Melting Point 63-64℃
Boiling Point 315℃
Density 1.23 g/cm3
Appearance yellow powder
Packaging 1g, 5g, 10g, 25g, 100g, 500g

Chemical Properties:

  • Stability: Acetyl groups enhance stability by preventing unwanted oxidation or side reaction with free hydroxyl groups.
  • Solubility: Slightly soluble in organic solvents (e.g., dichloromethane, ethyl acetate) but insoluble in water.
  • Reactivity: The anomeric (1-position) acetyl group is relatively more reactive, which is favorable for glycosylation or modification.

1,2,3-tri-O-acetyl-5-deoxy ribofuranose Applications

  • Synthetic Intermediate: Used in the synthesis of nucleosides, nucleotides, and carbohydrate-derived medicines (e.g., modified antiviral drugs).
  • Group Protecting Strategy: Acetyl groups are utilized as transient protecting groups in carbohydrate chemistry and can be removed later in a selective manner.

 

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