040-000-249 10-Deacetylbaccatin III, CAS 32981-86-5

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Synonyms 10-Deacetylbaccatin III, 10-DAB III
Source Taxus chinensis
Key words Intermediate, taxane, paclitaxel, cancer, Canada Yew tree
Related products Paclitaxel (Taxol), Taxus Chinensis Extract
Description

Description

Specifications

Product Name 10-Deacetylbaccatin III
CAS Registry Number 32981-86-5
Molecular Formula C29H36O10
Molecular Weight 544.60
Purity 99% HPLC
Appearance White powder
Shelf life 2years
Solubility Soluble in DMSO, methanol, ethanol, acetonitrile; insoluble in water

Description

10-deacetylbaccatin III (10-DAB) is extracted from Taxus Chinensis. It is the fifth intermediate in the biosynthetic pathway of paclitaxel. 10-DAB is also an essential intermediate in the biosynthetic of taxane.

Applications

  • Pharmaceutical intermediate
  • Pesticide intermediate 

Reference

  1. Barboni L, Giarlo G, Ballini R, Fontana G. 14Beta-hydroxy-10-deacetylbaccatin III as a convenient, alternative substrate for the improved synthesis of methoxylated second-generation taxanes. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5389-91. Epub 2006 Aug 4.
  2. Georgopoulou K, Smirlis D, Bisti S, Xingi E, Skaltsounis L, Soteriadou K. In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes. Planta Med. 2007 Aug;73(10):1081-8. Epub 2007 Aug 9.
  3. Zhang JF, Gong S, Guo ZG. Effects of different elicitors on 10-deacetylbaccatin III-10-O-acetyltransferase activity and cytochrome P450 monooxygenase content in suspension cultures of Taxus cuspidata cells. Cell Biol Int Rep (2010). 2010;18(1):e00009. doi: 10.1042/CBR20110001. Epub 2011 Apr 8.
  4. Frapolli R, Marangon E, Zaffaroni M, Colombo T, Falcioni C, Bagnati R, Simone M, D’Incalci M, Manzotti C, Fontana G, Morazzoni P, Zucchetti M. Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors. Drug Metab Dispos. 2006 Dec;34(12):2028-35.
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10-Deacetylbaccatin III
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by Kimberly L. Torres on 10-Deacetylbaccatin III

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