040-000-310 Abiraterone Acetate CAS 154229-18-2

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Synonyms Abiraterone
Keywords metastatic castration-resistant prostate cancer
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Description

Description

Abiraterone Acetate Specifications

Product Name Abiraterone Acetate
CAS Registry Number 154229-18-2
Molecular Formula C26H33NO2
Molecular Weight 391.55 g/mol
Purity >99.0 %
Appearance White powder
Package 1kg-25kg
Shelf life 2 years
Functions Treatment of mCSPC

Abiraterone Acetate Description:

Abiraterone Acetate is a CYP17 inhibitor, suitable for use in combination with prednisone for the treatment of patients with metastatic castration-refractory prostate cancer who have previously received docetaxel-containing chemotherapy.

abiraterone acetate

Abiraterone Acetate Applications:

Abiraterone Acetate is used in combination with prednisone, a corticosteroid, as a treatment for mCRPC (previously called hormone-resistant or hormone-refractory prostate cancer).

Reference:

  1. O’Donnell, A., Judson, I., Dowsett, M., et al. Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancer 90(12), 2317-2325 (2004).
  2. Ryan, C.J., Smith, M.R., de Bono, J.S., et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. New England Journal of Medicine 368(2), 138-148 (2013).
  3. Potter, G.A., Barrie, S.E., Jarman, M., et al. Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer. Journal of Medicinal Chemistry 38(13), 2463-2471 (1995).