An Overview on Hyaluronic Acid
How do you explain hyaluronic acid?
Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. Hyaluronic acid distributes widely in the human body, such as in connective, epithelial, and neural tissues. It can be obtained by extracting from cockscomb or through microorganism fermentation. The product in our company is all fermented products.
What are the types of Hyaluronic acid?
Food Grade: White or almost white powder or granules
Cosmetic Grade: White or almost white powder or granules
Injection Grade: White or almost white powder or fibrous aggregates
Medical Grade: White or almost white powder or fibrous aggregates
Cross-linked HA Gel:
mono-phase cross-linked HA (Juvederm™ Type)
What does hyaluronic acid consist of?
Material: mono-phase cross-linked HA gel with lidocaine (concentration:20 mg/ml). 1 ml syringe package.
bi-phase cross-linked HA (Restylane™ Type)
Material: bi-phase cross-linked gel (concentration: 20 mg/ml). 1 ml syringe package.
Molecular Weight & Viscosity
HA from different sources has the same primary structure but different molecular weights. The order of HA molecular weight ranges from 104 to 107 Dalton. HA has an incredible water-retaining capacity that makes HA solutions highly viscous, so the solution can retain moisture in the eyes, joints, and skin tissues. The clinical applications are strongly dependent on HA’s chain length, that is, the molecular weight. Intrinsic viscosity has been measured as a parameter of the molecular weight of HA, and the relation between intrinsic viscosity and the molecular weight is defined by the Mark-Houwink equation.
[η]=KMα
This equation describes the dependence of the intrinsic viscosity of a polymer on its relative molecular weight. Where [η] is the intrinsic viscosity, K and α are constant the values of which depend on the nature of the polymer and solvent as well as on temperature and M is usually one of the relative molecular mass averages.
What is hyaluronic acid and how does it work?
What is hyaluronic acid? HA is a humectant — a substance that retains moisture — and it is capable of binding over one thousand times its weight in water. This substance is naturally found in many areas of the human body, including the skin, eyes, and synovial fluid of the joints.
