070-000-250 Argireline, CAS 616204-22-9

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Synonyms Argireline; Acetyl Hexapeptide-3; Acetyl Hexapeptide-8
Keywords Anti-wrinkle, crease-resistant, cosmetic additives, Botulinum Toxin, skincare
Related products Botulinum Toxin, Vitamin CGrape Seed Extract, Pomegranate Seed Extract, Matrixyl


Argireline Specifications

Product Name Argireline
CAS Registry Number 616204-22-9
Molecular Formula C35H62N14O11S
Molecular Weight 887.028
Purity 99%
Recommend dose 0.2 -10%
Appearance White powder
Shelf life 2 years
Functions Diminishing the appearance of wrinkles, similar to botulinum toxin but safer and smoother

Argireline Description

Argireline is a small molecule composed of six amino acids. It is a famous wrinkle-removing active ingredient. Its mechanism is to inhibit the release of the neurotransmitter acetylcholine, thus reducing the contraction of muscles, thereby reducing the generation of dynamic lines and expression lines.

Argireline Applications

  • Cosmetic ingredient


  1. Hoppel M, Reznicek G, Kählig H, Kotisch H, Resch GP, Valenta C. Topical delivery of acetyl hexapeptide-8 from different emulsions: influence of emulsion composition and internal structure. Eur J Pharm Sci. 2015 Feb 20;68:27-35. doi: 10.1016/j.ejps.2014.12.006. Epub 2014 Dec 9.
  2. Wang Y, Wang M, Xiao XS, Huo J, Zhang WD. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41. doi: 10.3109/14764172.2013.769273. Epub 2013 Mar 6.
  3. Ruiz MA, Clares B, Morales ME, Cazalla S, Gallardo V. Preparation and stability of cosmetic formulations with an anti-aging peptide. J Cosmet Sci. 2007 Mar-Apr;58(2):157-71.
  4. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am J Clin Dermatol. 2013 Apr;14(2):147-53. doi: 10.1007/s40257-013-0009-9.
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by Helena on Argireline