Rotundine Powder Description

Rotundine is an organic compound with the formula C₂₁H₂₅NO₄. Rotundine is primarily used as an analgesic. Clinically, it is used for pain caused by gastric and duodenal ulcers, dysmenorrhea (menstrual cramp), pain of postpartum uterine contractions, tension-induced insomnia, and spasmodic cough.

Rotundine Powder Specifications

Properties

*The above product information is based on theoretical data. For specific requirements and detailed inquiries, please contact us.

Pharmacology of Rotundine

Rotundine possesses analgesic, sedative, hypnotic, and tranquilizing properties. It possesses a weaker analgesic effect than pethidine but a more powerful effect than ordinary antipyretic analgesics. At therapeutic doses, it causes neither respiratory depression nor gastrointestinal tract smooth muscle spasms. It is more effective for chronic persistent pain and visceral dull pain, while it is weaker in acute sharp pain (e.g., postoperative pain or trauma pain) and late cancer pain. It can cause sedation and hypnosis in addition to an analgesic effect.

Uses of Rotundine Powder

1. Analgesia: Primarily used in chronic dull pain, including:

• Headaches: Also useful in relieving tension headaches and headache in general.
• Dysmenorrhea: Also often employed to treat primary dysmenorrhea.
• Pain caused by disorders of the digestive system: Such as pain caused by gastric and duodenal ulcers, and spasmodic gastrointestinal pain.
• Postpartum pain of uterine contraction.
• Chronic persistent pain like joint pain and back pain.

2. Sedation and Hypnosis: Rotundine is sedative and hypnotic to a mild degree and is therefore employed for insomnias, especially those of painful origin. Its hypnotic effect is mild and will not cause rebound insomnia (worsening of insomnia on withdrawal).

Adverse Reactions

The frequent adverse reactions are drowsiness, dizziness, lethargy, and nausea. Its side effects are usually mild in comparison to other analgesics.

Precautions

• Use carefully in pregnant and nursing women.
• Tolerance may develop on prolonged administration.
• Use with caution when used in combination with central nervous system depressants; dose adjustment may be necessary.

People Also Ask

Q1. Why choose 98% purity rather than lower grades?
High purity minimizes toxic impurities (e.g., residual plant lectins). Demand Certificates of Analysis (CoA) that promise HPLC ≥98% and heavy metals (Pb ≤20 ppm).

Q2. Why does it cause mild nausea initially?
Alkaloids temporarily irritate the gastric mucosa. Take with food or switch to enteric-coated capsules. Symptoms typically pass in 3–5 days.

Q3.How long is the shelf life of Rotundine powder?
In a tightly closed container and protected from light, its shelf life is 2 years.

Q4. Does sunlight ruin its effectiveness?
Yes. Keep in amber bottles at <25°C. Discard if the powder becomes yellow.

Q5. Can Rotundine cause addiction?
No. As opposed to potent narcotic analgesics such as morphine and pethidine, Rotundine is not addictive, one of its key advantages.