Ademetionine Disulfate Tosylate Description

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions.

Product Name: Ademetionine Disulfate Tosylate (SAMe)
Synonyms: SAM-T; fo-1561; SAME-PTS; Ademetionine disulfate; ADEMETHIONINE SULFATE TOSYLATE; Ademetionine disulfate tosylate; AdeMethionine Disulfate Tosylate;
CAS #: 97540-22-2
Molecular Formula: C15H22N6O5S.2(H2SO4).C7H8SO3 Molecular Weight: 294.31  

Ademetionine Disulfate Tosylate Application

The therapy of depression, arthritis, chronic hepatitis, and cholestasia; moreover, it can be used in the prevention of liver cancer, or relieve the poisoning of chemicals, alcohol, and cancer to the liver, improve the curing of wound and growth of cartilage tissue; it also can adjust the function of nerve center system.  

Ademetionine Disulfate Tosylate Specification

TEST ITEM	STANDARD
Appearance	White or off-white powder
Identification by HPLC	The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of ademetionine in the system suitability solution as obtained in the assay
Identification by IR	Consistent with the spectrum obtained with the reference standard
Water(K.F.)	≤3.0%
Solubility	Soluble in water
TSFA by HPLC	21.7-23.5%
content of sulfate by IC	23.5-26.5%
SAME ion Assay by HPLC	50%-53%
Assay BY HPLC	≥95%
Isomeric ratio by HPLC	S,S-isomer≥60%
PH	1.0-2.0
Related compounds by HPLC	Adenine≤0.7% Methyltioadenosin≤0.7% Adenosine ≤0.5% S-adenosyl-homocysteine ≤0.7%
Residue on ignition	≤0.5%
Heavy metals	≤20ppm
TEST ITEM	STANDARD