040-000-274 Licochalcone A, CAS 58749-22-7

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Type Glycyyhiza
Source Glycyrrhiza glabra
Keywords Cosmetic ingredient, anti-cancer, anti-allergic, aftershave
Related products Glabridin, BenzocaineEthyl Ascorbic Acid


Specifications of Licochalcone A

Product Name Licochalcone A
CAS Registry Number 58749-22-7
Molecular Formula C21H22O4
Molecular Weight 338.4
Purity 6%-90% by HPLC
Loss on drying ≤5.00%
Appearance Yellow powder
Shelf life 2 years
Functions Anti-inflammation, anti-allergic, regulate immune system

Description of Licochalcone A

Licochalcone A is a natural chalcone in roots and rhizomes of licorice. It can anti-inflammation and whitening skin, thus, Licochalcone A has been used as a skin lighting agent in cosmetics. It has been reported that Licochalcone A (10-50 µM) induces apoptosis and suppresses migration and invasion of cancer cells in vitro. Its antibacterial properties against spore-forming bacteria and anti-parasitic actions have also been reported.

Licochalcone A (LCA), a chalconoid derived from the root of Glycyrrhiza inflata, has been known to possess a wide range of biological functions such as antitumor, and anti-angiogenesis, antiparasitic, anti-oxidant, antibacterial and anti-inflammatory effects.

licochalcone A application

Applications of Licochalcone A

  • Ingredient of cream, bath cream, and aftershave


  1. Weber, T.M., Ceilley, R.I., Buerger, A., et al. Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skincare regimen containing Licochalcone A. J.Cosmet.Dermatol. 5, 227-232 (2006).
  2. Tsai, J.P., Hsiao, P.C., Yang, S.F., et al. Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-κB mediated urokinase plasminogen activator expression. PLoS One 9(1), 1-12 (2014).
  3. Ziegler, H.L., Hansen, H.S., Staerk, D., et al. The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed. Antimicrobial Agents and Chemotherapy 48(10), 4067-4071 (2004).
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Licochalcone A
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by Judy Russell on Licochalcone A

OMG moment! It really works