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040-000-494 Tenofovir Alafenamide Hemifumarate

Tenofovir Alafenamide Hemifumarate
SKU: 040-000-494 Category:
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Type Active Pharmaceutical ingredient
CAS No. 1392275-56-7
Chemical Formula C46H62N12O14P2
Packaging customized
Assay ≥99%
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Description

Description

Tenofovir Alafenamide Hemifumarate Introduction

Tenofovir Alafenamide Hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Tenofovir Alafenamide Hemifumarate Specification

Type Active Pharmaceutical ingredient
CAS No. 1392275-56-7
Chemical Formula C46H62N12O14P2
Packaging customized
Storage conditions Keep in a dark place, Sealed in dry, Room Temperature

Tenofovir Alafenamide Hemifumarate Key Features

  1. High Potency at Low Doses

    • TAF is efficiently converted into the active metabolite Tenofovir Diphosphate within cells, inhibiting viral reverse transcriptase and blocking viral replication.

    • Clinically effective at 1/10 the dose of TDF (e.g., 25mg vs. 300mg) while maintaining comparable efficacy.

  2. Improved Safety Profile

    • Reduces kidney and bone-related side effects (e.g., osteoporosis, renal impairment), making it suitable for long-term therapy.

Tenofovir Alafenamide Hemifumarate Applications

Tenofovir Alafenamide Hemifumarate is a prodrug of tenofovir.

TAF vs. TDF Comparison

Feature TAF (Tenofovir Alafenamide) TDF (Tenofovir Disoproxil Fumarate)
Dosage Low (25mg) High (300mg)
Targeted Delivery Higher intracellular concentration Systemic distribution
Kidney/Bone Toxicity Significantly reduced Requires renal monitoring
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