040-000-515 Valsartan

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Type Active Pharmaceutical ingredient
Synonym N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
CAS No. 137862-53-4
Chemical Formula C24H29N5O3
Appearance white powder
Packaging 1g, 5g
Assay ≥98%
Related Products Irbesartan, Candesartan Cilexetil, Olmesartan Medoxomil(新产品)
Description

Description

Valsartan Introduction

Valsartan is a specific angiotensin II (AT1) receptor antagonist, and it is another non-skin AT1 receptor antagonist used in clinic after losartan. It can regulate systemic blood pressure and maintain electrolyte and body fluids.

It selectively acts on the AT1 receptor subtype and blocks the binding of Ang II to the AT1 receptor, thereby inhibiting vasoconstriction and the release of aldosterone, resulting in a hypotensive effect, but does not inhibit the release of aldosterone caused by potassium ions (K+).

The antihypertensive effect is better than that of enalapril, and it is suitable for the treatment of anti-hypertension, mild to moderate primary hypertension, especially secondary hypertension caused by kidney damage, which can significantly reduce the high blood pressure associated with diabetes or normal renal function. Proteinuria in patients with blood pressure, and has the renal protective effect of promoting the excretion of uric acid and urinary sodium.

The drug is also indicated to reduce cardiovascular mortality in high-risk patients after a heart attack.

Valsartan Specification

Appearance white powder
Melting Point 116-117℃
Boiling Point 684.9±65.0℃
Density 1.212±0.06 g/cm3
Storage Condition 2-8℃
Content 98.0%
Packaging 1g, 5g

 

Valsartan Applications

The antihypertensive effect of Valsartan is better than that of enalapril, and it is suitable for the treatment of anti-hypertension, mild to moderate primary hypertension, especially secondary hypertension caused by kidney damage, which can significantly reduce the high blood pressure associated with diabetes or normal renal function.