HA6977 DL-Synephrine Powder (CAS No. 94-07-5)

Description

DL-Synephrine Powder Description

DL-Synephrine Powder is a dual-isomer bioactive Citrus alkaloid standardized to ≥98% purity. It functions as a selective α1-adrenergic receptor agonist (EC50 = 8.2 μM) to promote lipolysis and thermogenesis without significant β-adrenergic effects. Clinically validated for safe use at a dose of ≤100mg/day, it is formulated for thermogenic fat-burning applications that require precise modulation of adrenergic activity. This biogenic amine features:

• White to off-white crystalline appearance
• Melting point: 184-187°C
• Moderate water solubility (25 mg/mL at 20°C)
• Good solubility in methanol, ethanol, and DMSO
• Characteristic IR absorption bands at 3350 cm⁻¹ (O-H), 1605 cm⁻¹ (aromatic), and 1240 cm⁻¹ (C-O)
• UV-Vis λmax: 274 nm (aqueous solution)

Structural Characteristics

• Orthorhombic crystal system
• Para-hydroxylated phenyl ring with N-methyl ethanolamine side chain
• NMR aromatic proton signals: 6.7-7.2 ppm
• Birefringent under polarized light

Quality Specifications

• Purity: ≥98% by RP-HPLC
• Moisture uptake: <3% at 60% RH
• Thermal stability: Up to 85°C
• Decomposition: Oxidative pathways above 85°C

Pharmacological Activity

• Selective α₁-adrenergic receptor agonist
• EC50: 8.2 μM
• Structural analog of endogenous catecholamines

DL-Synephrine Powder Specifications

Properties

*The above product information is based on theoretical data. For specific requirements and detailed inquiries, please contact us.

DL-Synephrine Powder Applications

1. Nutraceuticals

• Weight management formulations (5-20% concentration)
• Safe dosage ≤100 mg/day
• Lipolytic activity via α1-adrenergic stimulation

2. Pharmaceuticals

• Cardiovascular research compound
• Decongestant development
• High purity (≥98%) for receptor studies

3. Cosmetics

• Topical fat-reduction products (0.5-2% w/w)
• Localized adipocyte targeting
• Minimal systemic absorption

4. Analytical Standards

• HPLC/GC-MS reference material
• Characteristic retention time: 6.3±0.2 min (C18)
• Sympathomimetic drug screening

5. Sports Nutrition

• Ergogenic performance enhancement
• Anaerobic capacity support
• Catecholamine receptor modulation

DL-Synephrine Powder FAQs

Q1. How does DL-Synephrine differ from natural synephrine in weight management products?

DL-Synephrine is a synthetic racemic mixture providing consistent α1-adrenergic receptor activation (EC50=8.2μM), whereas natural citrus extracts vary in D/L isomer ratios. Its standardized melting point (184-187°C) and ≥98% HPLC purity ensure batch-to-batch reproducibility in thermogenic formulations.

Q2. What analytical methods confirm DL-Synephrine purity in bulk supplements?

Reverse-phase HPLC with methanol-water gradients (65:35 v/v) is mandatory, detecting the primary peak at 6.3±0.2 minutes retention time. Complementary FTIR validation should show characteristic phenolic C-O stretch at 1240 cm⁻¹ and absence of solvent residues below 500 ppm.

Q3. Why is DL-Synephrine preferred over ephedrine in pharmaceutical research?

DL-Synephrine exhibits selective α1-agonism without significant β-adrenergic activity, minimizing cardiovascular side effects. Its orthorhombic crystal structure enhances stability during in vitro assays, and thermal decomposition initiates only above 85°C.