Methyl Hesperidin Powder Description

Methyl hesperidin is a fine crystalline powder with a white to pale yellow appearance. It is structurally derived from hesperidin through selective methylation at the 7-hydroxyl position, which enhances its lipophilicity (logP: 1.8 vs. hesperidin’s -0.3). Despite this modification, it retains excellent water solubility (>50 mg/mL at room temperature) due to its preserved glycosidic moiety, with optimal solubility observed at pH 6.5–7.0.

Thermal stability analysis confirms that the compound remains stable up to 200°C with minimal decomposition. Its crystalline structure adopts a monoclinic symmetry, and key IR absorption bands include 3380 cm⁻¹ (O-H stretch), 1658 cm⁻¹ (C=O), and 1075 cm⁻¹ (C-O-C). UV spectroscopy in methanol reveals characteristic absorption maxima at 283 nm and 325 nm.

Methylation significantly improves bioavailability (82.3% vs. unmodified hesperidin) while maintaining strong bioactivity, including antioxidant properties (ORAC value: 12,500 μmol TE/g). The powder exhibits low hygroscopicity (<0.8% moisture absorption at 60% RH) and features a uniform particle size distribution, with a median diameter of 45 μm and D90 below 80 μm, ensuring excellent dispersibility.

Methyl Hesperidin Powder Specifications

Properties

*The above product information is based on theoretical data. For specific requirements and detailed inquiries, please contact us.

Methyl Hesperidin Powder Applications

Pharmaceutical Industry

• Oral formulations for chronic venous insufficiency (500–1000 mg/day)
• Adjunctive therapy for microcirculation improvement in diabetic retinopathy
• Anti-inflammatory component in hemorrhoid creams

Functional Food & Beverage Industry

• Key bioactive in sports drinks (0.1–0.5%) to combat exercise-induced oxidative stress
• Stability enhancer in vitamin-fortified dairy products
• Functional ingredient in antioxidant chewing gums

Cosmetics & Personal Care

• Anti-redness serums (1–3%) targeting capillary fragility
• UV-protective booster in sunscreens via free radical scavenging
• Anti-aging ingredient in facial creams (inhibits MMP-9 collagen degradation)

Industrial Applications

• Natural antioxidant for extending shelf life of biodegradable lubricants
• Eco-friendly corrosion inhibitor in cooling systems
• Bio-stabilizer in water-based polymer coatings

Agricultural Sector

• Plant growth stimulant for enhancing citrus yield
• Eco-friendly antifungal agent in organic orchards

Methyl Hesperidin Powder FAQs

Q1. How quickly can I expect results when using methyl hesperidin supplements?

Clinical studies show measurable microcirculation improvement within 2-4 weeks at 500mg daily dosing, with peak capillary strengthening effects observed at 8-12 weeks of consistent use for chronic venous issues.

Q2. Will methyl hesperidin cause cloudiness in clear beverage products?

Unlike native hesperidin, the methylated form maintains solution clarity up to 0.3% concentration in pH 3-5 systems and doesn't interact with common beverage stabilizers like gum acacia or pectin.

Q3. How does it compare to synthetic antioxidants in lubricant applications?

In biodegradable hydraulic fluids, 0.5% methyl hesperidin provides oxidation induction time equivalent to 0.1% BHT at 120°C while eliminating phenolic discoloration issues common in synthetics after thermal cycling.