Cholic acid Introduction

Cholic acid is a major primary bile acid produced in the liver as a metabolite in bile formation. It is a white crystalline substance that is soluble in alcohol and acetic acid but relatively insoluble in water and ether. Cholic acid, along with other bile acids, is involved in the digestion and absorption of dietary fats in the small intestine.

Cholic acid Specification

Appearance	White to cream-colored powder
Melting point	200-201℃
Boiling Point	449.08℃
Density	1.0310g/cm3
Packaging	Customized

Cholic Acid Functions and Benefits

• Fat Digestion and Absorption: Cholic acid is a crucial component of bile, which is released into the intestine to help digest dietary fats and aid in their absorption into the body.
• Vitamin Absorption: Bile acids like cholic acid also help in the absorption of fat-soluble vitamins (A, D, E, and K) from the intestine.
• Cholesterol Regulation: The synthesis of cholic acid in the liver is a major pathway for the metabolism and excretion of cholesterol.

Cholic acid Applications

• Medical Use: Cholic acid is used medically in the treatment of certain liver and gallbladder diseases. For instance, it is used in a product called chenodeoxycholic acid to dissolve gallstones. It is also used in the treatment of bile acid synthesis disorders due to single enzyme defects and peroxisomal disorders, including Zellweger spectrum disorders.
• Research Use: Cholic acid is often used in research settings, particularly in studies related to lipid digestion and absorption, cholesterol metabolism, and the role of bile acids in health and disease.
• Industrial Use: Cholic acid is used as a biochemical tool in the preparation of artificial and functionalized membranes.

Cholic acid Side Effects

While cholic acid plays essential roles in the body, like other substances, it must be balanced. Like other bile acids, an excess of cholic acid can be harmful and lead to conditions such as gallstones.