HA6995 Papaya Leaf Extract Powder

Description

Papaya Leaf Extract Powder Description

Papaya Leaf Extract Powder is a hygroscopic pale brown to yellowish-colored fine powder with a faint herbal odor. Its prominent bioactive constituents are flavonoids (quercetin, kaempferol), glycosides, and alkaloids (carpaine), along with enzymes papain and chymopapain. The flavonoids exhibit high free-radical scavenging activity, reducing oxidative stress by inhibiting lipid peroxidation and stimulating the production of glutathione. Alkaloids modulate immune response through suppression of TNF-α and modulation of interleukins, while carpaine inhibits platelet aggregation directly and stimulates thrombopoietin gene expression for platelet manufacture. Thermally stable below 60°C, the extract becomes heat-damaged at temperatures above this, necessitating low-heat processing.

Solubility is pH-dependent with the greatest solubility in hydroalcoholic solvents but with little stability in acidic gastric fluids, having a tendency to need enteric coating for oral administration. Analytical profiles confirm trace residues of glucosinolates and glutathione, which synergize to enhance bioavailability. Heavy metal residues are within pharmacopeial requirements (lead ≤20 ppm, arsenic ≤3 ppm), and microbial impurities are controlled to provide safety. Stability requires sequestration from light and moisture and a normal shelf life of 24 months under dried storage at 15–25°C.

Papaya Leaf Extract Powder Applications

• Pharmaceuticals and Nutraceuticals: Plated into capsules, syrups, and tablets to increase platelet levels in dengue hemorrhagic fever and chemotherapy-induced thrombocytopenia. Alkaloids stimulate the function of bone marrow megakaryocytes, and flavonoids suppress viral replication in enveloped viruses, benefitting adjunctive therapy for viral hemorrhagic fevers and immunological rehabilitation.
• Functional Foods and Beverage: Added to immunity-enhancing tonics and recovery drinks targeting metabolic health. A natural stomach aid due to papain enzyme activity, which enhances protein hydrolysis and soothes bloating in functional drinks and meal replacers.
• Cosmetics and Personal Care: Developed into anti-inflammatory creams and serums for acne or sensitive skin. Flavonoids inhibit histamine release and COX-2 activity to reduce redness, while antioxidants neutralize UV-induced free radicals, inhibiting photoaging in sunscreens and repair moisturizers.
• Agriculture and Biopesticides: Employed as a natural insecticide to control agricultural pests. Alkaloids suppress the larval growth of Aedes aegypti mosquitoes and Spodoptera insects, serving as an environmentally friendly alternative to synthetic pesticides in integrated pest management regimes.
• Biomedical Research and Diagnostics: Explored anticancer activities through apoptosis induction against solid tumors and leukemia cell lines. Carpaine exhibits dose-dependent cytotoxicity, and lectins serve as glycobiology reagents in tumor-specific carbohydrate marker detection in histopathological assays.

Papaya Leaf Extract Powder Specifications

Properties

*The above product information is based on theoretical data. For specific requirements and detailed inquiries, please contact us.

Papaya Leaf Extract Powder FAQs

Q1. Can this powder increase platelet count in dengue fever?

Clinical studies show platelet elevation within 24–48 hours at 1,100 mg/day doses. It stimulates thrombopoietin genes—optimal results require starting at fever onset and continuing 5 days post-recovery.

Q2. Is it safe with blood-thinning medications like warfarin?

Avoid concurrent use. Alkaloids may potentiate anticoagulant effects, increasing bleeding risk. Consult your doctor before combining with any antiplatelet/anticoagulant drugs.

Q3. How long until I see immune benefits during cold season?

Most users report fewer infections after 2–3 weeks of 500 mg daily. For acute illness, take 300 mg 3x/day with zinc to shorten duration.