Acyclovir Specifications

Product Name	Acyclovir
CAS Registry Number	59277-89-3
Molecular Formula	C8H11N5O3
Molecular Weight	225.21 g/mol
Purity	98% HPLC min
Appearance	White solid
Storage	Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Shelf life	The product can be stored for up to 24 months under the storage instruction
Functions	Acyclovir is used to treat infections caused by certain types of viruses.

Acyclovir Description

Acyclovir is a nucleoside analogue and antiviral agent used in the therapy of herpes and varicella-zoster virus infections. Acyclovir has not been associated with clinically apparent liver injury. Acyclovir (ay sye' kloe vir) is an acyclic purine nucleoside analogue (acycloguanosine) which has antiviral activity against many herpes viruses, including herpes simplex 1 and 2, cytomegalovirus, Ebstein-Barr virus and varicella-zoster.

Acyclovir is phosphorylated intracellularly by viral kinases, and the resultant triphosphate competes with guanosine for incorporation into viral DNA blocking viral DNA polymerase activity. Acyclovir is indicated for therapy of localized as well as disseminated herpes simplex infections, both type 1 and 2. It is also used for varicella-zoster infections (chickenpox and shingles). Acyclovir was approved for use in herpes virus infections in the United States in 1982 and is still widely used in treatment and prophylaxis of genital and mucocutaneous herpes simplex infection with almost 5 million prescriptions filled yearly.

Acyclovir Applications

Acyclovir is a nucleoside analogue and antiviral agent used in the therapy of herpes and varicella-zoster virus infections. Acyclovir has not been associated with clinically apparent liver injury.

Reference:

1. Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868
2. Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734
3. Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716