Synonyms: (+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
CAS Registry Number: 59-05-2
Usage: Used as an antineoplastic and antirheumatic. A folic Acid antagonist
Description of Methotrexate
Methotrexate was first used in anti-cancer with its less toxicity comparing to other treatment. Methotrexate can suppress DNA synthesis so it can be a good drug in the treatment of cancer.
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to the accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methotrexate.
Chemical properties of Methotrexate
|Appearance||Orange or yellow powder|
|Package||1 kg/pack or customized|
|Solubility||Almost insoluble in water, ethanol, chloroform or ether; soluble in dilute alkali solution, dissolved in dilute hydrochloric acid|
|Storage||Stored in cool & dry places in room temperature, protected from direct sunlight and heat.|
Application of Methotrexate
·Raw material of early rheumatoid drugs
·Raw materials of anti-cancer drugs
·For a variety of acute leukemia, chorionic epithelial cell carcinoma, malignant mole and psoriasis
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