020-000-355 miniHA™ HA-Oligo Degraded by Hyaluronidase

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Product Name miniHA™ HA-Oligo Degraded by Hyaluronidase
CAS No. 9067-32-7
Appearance White or almost white powder
Type Sodium Salt
Keywords Sodium Hyaluronate, Hyaluronic Acid
Related products Hyacross™ Hyaluronic Acid Elastomer, Hymagic™ -AcHA Sodium Acetylated Hyaluronate, Hymagic™-4D, cationHA™ Substantive Sodium Hyaluronate
Description

Description

miniHA™ HA-Oligo Degraded by Hyaluronidase Description

miniHA™ HA-Oligo Degraded by Hyaluronidase is a new product developed by bio-enzymatic degradation technology. Its molecular weight varies from 3,000Da to 10,000Da, allowing it to be absorbed more easily by the skin and thus to have a deep moisturizing effect.

miniHA™ HA-Oligo Degraded by Hyaluronidase Specification

miniHA™ HA-Oligo Degraded by Hyaluronidase has a molecular weight 3,000Da~10,000Da and the average molecule size is less than 25nm, so it penetrates easily into the skin and nourish the skin.

Product Name miniHA™ HA-Oligo Degraded by Hyaluronidase
Molecular Weight 3,000Da~10,000Da
Assay of HA ≥ 95%
Glucuronic Acid ≥46%
pH 5.0-8.0
Transparency ≥99.0%
Protein ≤0.05%
Heavy Metals ≤20ppm
Loss on Drying ≤10.0%
Arsenic ≤ 2ppm
Bacterial count <100cfu/g
Mold and yeast <20cfu/g
Residue on Ignition ≤20.0%
Intrinsic viscosity ≤0.47dL/g
Escherichia Coli Negative
Staphylococcus aureus Negative
Pseudomonas aeruginosa Negative
Storage Light proof, ordinary temperature and sealed container
Validity Two Years

miniHA™ HA-Oligo Degraded by Hyaluronidase Applications

In the Cosmetic Field

  • Transdermal absorption, deep moisturizing
  • Repairing damaged cells and scavenge free radicals
  • Anti-aging

 

In the Food Health Field

  • Strong water retention and water retention capacity

 

In the Medical Field

  • Antioxidant
  • Anti-tumor
  • Immunomodulatory
  • Inflammatory and wound healing
  • Pro-angiogenic

 

miniHA™ HA-Oligo Degraded by Hyaluronidase is developed by bio-enzymatic degradation technology. In mammals, the enzymatic degradation of HA results from the action of three types of enzymes: hyaluronidase (hyase), b-d-glucuronidase, and β-Nacetyl-hexosaminidase. Throughout the body, these enzymes are found in various forms, intracellularly and in serum. In general, hyase cleaves high molecular weight HA into smaller oligosaccharides while β-d-glucuronidase and β-N-acetylhexosaminidase further degrade the oligosaccharide fragments by removing nonreducing terminal sugars (Leach and Schmidt, 2004). The degradation products of hyaluronan, oligosaccharides and very low molecular weight hyaluronan, exhibit pro-angiogenic properties (Mio and Stern, 2002). By catalyzing the hydrolysis of hyaluronic acid, a major constituent of the interstitial barrier, hyaluronidase lowers the viscosity of hyaluronic acid, thereby increasing tissue permeability. It is, therefore, used in medicine in conjunction with other drugs in order to speed their dispersion and delivery.

Reference

  1. Necas , L. Bartosikova , P. Brauner , J. Kolar: Hyaluronic acid (hyaluronan): a review. Veterinarni Medicina, 53, 2008 (8): 397–411